News and Events | Working Groups | Short-Term Scientific Missions | Management Committee | Members |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Gnaiger Erich
MitoPedia topics: EAGLE
COST: Member COST WG1: WG1 COST WG2: WG2 COST WG3: WG3 COST WG4: WG4 COST Mentor: Mentor
Name | Gnaiger Erich, Ao.Univ.-Prof.i.R., PhD
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Institution |
Editor-in-chief: Bioenergetics Communications - https://www.bioenergetics-communications.org BEC Series Editor: Tributes to pioneers in bioenergetics - wandering in the garden of memories
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Address | Oroboros Instruments
Schoepfstrasse 18, A-6020 |
City | Innsbruck |
State/Province | |
Country | Austria |
[email protected] | |
Weblink | www.oroboros.at, www.bioblast.at, Mitochondrial Physiology Society |
O2k-Network Lab | AT Innsbruck Oroboros |
Labels:
Field of research: Basic
Topics: High-resolution respirometry, MitoPedia: high-resolution terminology
Publications
Published | Reference | |
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Cardoso 2025 Biochim Biophys Acta Mol Basis Dis | 2025 | Cardoso LHD, Cecatto C, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Makrecka-Kuka M, Gnaiger E, Liepinsh E (2025) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. Biochim Biophys Acta Mol Basis Dis 1871:167544. https://doi.org/10.1016/j.bbadis.2024.167544 |
EBEC2024 Bioenerg Commun | 2024 | Tindle-Solomon L, Schmitt S, Gnaiger C, Cardoso LHD, Cocco P, Gnaiger E, eds (2024) EBEC2024 Late-breaking abstracts. Bioenerg Commun 2024.6. https://doi.org/10.26124/bec.2024-0006 |
Zunica 2024 Mol Metab | 2024 | Zunica ERM, Axelrod CL, Gilmore LA, Gnaiger E, Kirwan JP (2024) The bioenergetic landscape of cancer. Mol Metab 86:101966. https://doi.org/10.1016/j.molmet.2024.101966 |
Pfleger 2024 Biochim Biophys Acta Bioenerg | 2024 | Pfleger A, Arc E, Grings M, Gnaiger E, Roach T (2024) Flavodiiron proteins prevent the Mehler reaction in Chlamydomonas reinhardtii. Biochim Biophys Acta Bioenerg 1865:149497. https://doi.org/10.1016/j.bbabio.2024.149497 |
Doerrier 2024 Free Radic Biol Med | 2024 | Doerrier C, Gama-Perez P, Pesta D, Distefano G, Soendergaard SD, Maise Chroeis K, Gonzalez-Franquesa A, Goodpaster BH, Prats C, Sales-Pardo M, Guimera R, Coen PM, Gnaiger E, Larsen S, Garcia-Roves PM (2024) Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. Free Radic Biol Med 223:384-97. https://doi.org/10.1016/j.freeradbiomed.2024.07.039 |
Cardoso 2024 BEC | 2024 | Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005 |
Leo 2024 MitoFit | 2024 | Leo E, Rychtarova L, Garcia-Souza LF, Åsander Frostner E, Elmér E, Gnaiger E (2024) High-resolution respirometry in a small-volume chamber. MitoFit Preprints 2024.4.v2. https://doi.org/10.26124/mitofit:2024-0004.v2 - Accepted on 2024-10-27 as Manuscript JoVE67442R2 for publication in JoVE |
Azzi 2024 BEC-Tributes | 2024 | Azzi A, Gnaiger E (2024) Tributes to pioneers in bioenergetics - wandering in the garden of memories. Bioenerg Commun 2024.3.v1. https://doi.org/10.26124/bec:2024-0003 |
Gnaiger 2024 MitoFit | 2024 | Gnaiger E (2024) Addressing the ambiguity crisis in bioenergetics and thermodynamics. MitoFit Preprints 2024.3. https://doi.org/10.26124/mitofit:2024-0003 |
Donnelly 2024 Redox Biol | 2024 | Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037 |
EBEC2024 Abstract Book 2024 Biochim Biophys Acta Bioenerg | 2024 | Tindle-Solomon L, Schmitt S, Gnaiger C, Cardoso LHD, Gnaiger E, eds (2024) EBEC2024 Abstract Book. Biochim Biophys Acta – Bioenergetics. 1865S:1–156. |
Meszaros 2024 Transpl Int | 2024 | Meszaros AT, Weissenbacher A, Schartner M, Egelseer-Bruendl T, Hermann M, Unterweger J, Mittelberger C, Reyer BA, Hofmann J, Zelger BG, Hautz T, Resch T, Margreiter C, Maglione M, Komlódi T, Ulmer H, Cardini B, Troppmair J, Öfner D, Gnaiger E, Schneeberger S, Oberhuber R (2024) The predictive value of graft viability and bioenergetics testing towards the outcome in liver transplantation. Transpl Int 37:12380. https://doi.org/10.3389/ti.2024.12380 |
Baglivo 2024 MitoFit | 2024 | Baglivo E, Cardoso LHD, Cecatto C, Gnaiger E (2024) Stability of mitochondrial respiration medium used in high-resolution respirometry with living and permeabilized cells. MitoFit Preprints 2024.7. https://doi.org/10.26124/mitofit:2024-0007 |
Timon-Gomez 2024 MitoFit | 2024 | Timón-Gómez A, Doerrier C, Sumbalová Z, Garcia-Souza LF, Baglivo E, Cardoso LHD, Gnaiger E (2024) Analysis of mitochondrial respiratory pathway and coupling control by substrate-uncoupler-inhibitor titration reference protocols. MitoFit Preprints 2024.8. https://doi.org/10.26124/mitofit:2024-0008 |
Ravasz 2024 Sci Rep | 2024 | Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, Marzullo BP, Tennant DA, Greenwood B, Kitayev A, Hill C, Komlódi T, Doerrier C, Cunatova K, Fernandez-Vizarra E, Gnaiger E, Kiebish Michael A, Raska A, Kolev K, Czumbel B, Narain NR, Seyfried TN, Chinopoulos C (2024) Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia. Sci Rep 14:1729. https://doi.org/10.1038/s41598-024-51365-4 |
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis | 2024 | Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033 |
Patil 2024 J Exp Biol | 2024 | Patil YN, Gnaiger E, Landry AP, Leno ZJ, Hand SC (2024) OXPHOS capacity is diminished and the phosphorylation system inhibited during diapause in an extremophile, embryos of Artemia franciscana. J Exp Biol 227:jeb.245828. https://doi.org/10.1242/jeb.245828 |
Gnaiger 2024 J Biol Chem | 2024 | Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 |
Spielmann 2023 Mamm Genome | 2023 | Spielmann N, Schenkl C, Komlódi T, da Silva-Buttkus P, Heyne E, Rohde J, Amarie OV, Rathkolb B, Gnaiger E, Doenst T, Fuchs H, Gailus-Durner V, de Angelis MH, Szibor M (2023) Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mamm Genome 34:229-43. https://doi.org/10.1007/s00335-022-09973-w |
Molina 2023 JAMA Cardiol | 2023 | Molina AJA, Gnaiger E, Kitzman DW (2023) Mitochondrial respiration and exercise performance in patients with heart failure with preserved ejection fraction-reply. JAMA Cardiol 8:1101-2. https://doi.org/10.1001/jamacardio.2023.3577 |
MiP2023 Bioenerg Commun | 2023 | Gnaiger E, Timon-Gomez A, Tindle-Solomon L, Cocco P, eds (2023) MiPschool and MiPconference 2023. Bioenerg Commun 2023.2. https://doi.org/10.26124/bec:2023-0002 |
Scandalis 2023 JAMA Cardiol | 2023 | Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. JAMA Cardiol 8:575–84. https://doi.org/10.1001/jamacardio.2023.0957 |
Pallag 2022 Int J Mol Sci | 2022 | Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. Int J Mol Sci 23:5111. https://doi.org/10.3390/ijms23095111 |
Zdrazilova 2022 PLOS ONE | 2022 | Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496 |
Fischer 2022 Metabolites | 2022 | Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. Metabolites 12:270. https://doi.org/10.3390/metabo12030270 |
Gnaiger 2022.1 Bioenerg Commun | 2022 | Gnaiger E, Cardoso LHD, Tindle-Solomon L, Cocco P, eds (2022) Bioblast 2022: BEC inaugural conference. Bioenerg Commun 2022.1. https://doi.org/10.26124/bec:2022-0001 |
Heimler 2022 BEC | 2022 | Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. Bioenerg Commun 2022.2. https://doi.org/10.26124/bec:2022-0002 |
Baglivo 2022 BEC | 2022 | Baglivo E, Cardoso LHD, Cecatto C, Gnaiger E (2022) Statistical analysis of instrumental reproducibility as internal quality control in high-resolution respirometry. Bioenerg Commun 2022.8. https://doi.org/10.26124/bec:2022-0008 |
Meszaros 2022 EBioMedicine | 2022 | Meszaros AT, Hofmann J, Buch ML, Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. EBioMedicine 85:104311. https://doi.org/10.1016/j.ebiom.2022.104311 |
Karavyraki 2022 BEC | 2022 | Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioenerg Commun 2022.11. https://doi.org/10.26124/bec:2022-0011 |
Donnelly 2022 BEC | 2022 | Donnelly C, Schmitt S, Cecatto C, Cardoso LHD, Komlódi T, Place N, Kayser B, Gnaiger E (2022) The ABC of hypoxia – what is the norm. Bioenerg Commun 2022.12.v2. https://doi.org/10.26124/bec:2022-0012.v2 |
Torres-Quesada 2022 Cancers (Basel) | 2022 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. Cancers (Basel) 14:3917. https://doi.org/10.3390/cancers14163917 |
Bastos Sant'Anna Silva 2021 Cancers (Basel) | 2021 | Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. Cancers 13:1727. https://doi.org/10.3390/cancers13071727 |
Fischer 2021 Antioxidants | 2021 | Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe-/- related hemochromatosis alter hepatic mitochondrial function. Antioxidants 10:1818. https://doi.org/10.3390/antiox10111818 |
Went 2021 MitoFit PB | 2021 | Went N, Di Marcello M, Gnaiger E (2021) Oxygen dependence of photosynthesis and light-enhanced dark respiration studied by High-Resolution PhotoRespirometry. MitoFit Preprints 2021.05. https://doi.org/10.26124/mitofit:2021-0005 |
Gnaiger 2021 Bioenerg Commun | 2021 | Gnaiger E (2021) Beyond counting papers – a mission and vision for scientific publication. Bioenerg Commun 2021.5. https://doi.org/10.26124/bec:2021-0005 |
Hoppel 2021 Front Physiol | 2021 | Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. Front Physiol 12:632664. https://doi.org/10.3389/fphys.2021.632664 |
Cardoso 2021 BEC MgG | 2021 | Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. Bioenerg Commun 2021.1. https://doi.org/10.26124/bec:2021-0001 |
Komlodi 2021 BEC Q | 2021 | Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioenerg Commun 2021.3. https://doi.org/10.26124/bec:2021-0003 |
Gnaiger 2021 MitoFit BCA | 2021 | Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.08. https://doi.org/10.26124/mitofit:2021-0008 |
Oemer 2021 J Lipid Res | 2021 | Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. J Lipid Res 100111. https://doi.org/10.1016/j.jlr.2021.100111 |
Vernerova 2021 Biomedicines | 2021 | Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O (2021) Mitochondrial respiration of platelets: comparison of isolation methods. Biomedicines 9:1859. https://doi.org/10.3390/biomedicines9121859 |
Komlodi 2021 BEC AmR-O2 | 2021 | Komlódi T, Sobotka O, Gnaiger E (2021) Facts and artefacts on the oxygen dependence of hydrogen peroxide production using Amplex UltraRed. Bioenerg Commun 2021.4. https://doi.org/10.26124/bec:2021-0004 |
Gnaiger 2020 MitoFit x | 2021 | Gnaiger E (2021) The elementary unit — canonical reviewer's comments on: Bureau International des Poids et Mesures (2019) The International System of Units (SI) 9th ed. MitoFit Preprints 2020.04.v2. https://doi.org/10.26124/mitofit:200004.v2 |
Hoppel 2021 Cells | 2021 | Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. Cells 10:2088. https://doi.org/10.3390/cells10082088 |
Gnaiger 2020 BEC MitoPathways | 2020 | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002 |
Schoepf 2020 Nat Commun | 2020 | Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Giese I, Sorn P, Sant’Anna-Silva AC, Iglesias-Gonzalez J, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487. https://doi.org/10.1038/s41467-020-15237-5 |
Huete-Ortega 2020 MitoFit Preprint Arch EA | 2020 | Huete-Ortega M, Di Marcello M, Iglesias-Gonzalez J, Gnaiger E (2020) High-resolution respirometry for chloroplast and mitochondrial bioenergetics in Chlamydomonas reinhardtii ― towards biotechnology exploitations. MitoFit Preprint Arch EA20.1. https://doi.org/10.26124/mitofit:ea20.algaeurope.0001 |
Brown 2020 BMJ | 2020 | Brown Robert A, Rhein Helga M, Alipio Mark M, Annweiler Cedric, Gnaiger Erich, Holick Michael F, Boucher Barbara J, Duque Gustavo, Féron François, Kenny Rose Anne, Montero-Odasso Manuel, Minisola Salvatore, Rhodes Jonathan, Haq Afrozul, Bejerot Susanne, Reiss Lina AJ, Zgaga Lina, Crawford Michael A, Fricker Rosemary A, Cobbold Peter, Lahore Henry W, Humble Mats B, Sarkar Amrita, Karras Spiros, Iglesias-Gonzalez Javier, Gezen-Ak Duygu, Dursun Erdinc, Cooper Isabella, Grimes David, de Voil Cedric WB (2020) COVID-19 ’ICU’ risk – 20-fold greater in the vitamin D deficient. BAME, African Americans, the older, institutionalised and obese, are at greatest risk. Sun and ‘D’-supplementation – game-changers? Research urgently required. BMJ 2020;369:m1548. https://doi.org/10.1136/bmj.m1548 |
Hassan 2020 MitoFit Preprint Arch | 2020 | Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3. https://doi.org/10.26124/mitofit:200003 |
MitoEAGLE blood cells 1 | 2020 | Åsander Frostner Eleonor*, Aburel Oana M*, Avram Vlad F*, Calabria Elisa, Castelo Rueda Maria Paulina*, Chamkha Imen*, Čižmárová Beata, Danila Maria-Daniela*, Doerrier Carolina*, Eckert Gunter P*, Ehinger Johannes K, Elmer Eskil*, Garcia-Souza Luiz F*, Gnaiger Erich*, Hoppel Florian*, Karabatsiakis Alexander*, Keppner Gloria, Kidere Dita*, Krako Jakovljević Nina, Labieniec-Watala Magdalena*, Lelcu Theia*, Micankova Petra, Michalak Slawomir*, Molina Anthony JA*, Pavlovic Kasja, Pichler Irene*, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina*, Silaidos Carmina*, Sjövall Fredrik*, Sobotka Ondrej*, Sumbalova Zuzana*, Swiniuch Daria, Vernerova Andrea*, Volani Chiara*, Vujacic-Mirski Ksenija*, Watala Cezary* (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *Confirmed |
BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
Gnaiger 2019 MitoFit Preprints Editorial | 2019 | Gnaiger E (2019) Editorial: A vision on preprints for mitochondrial physiology and bioenergetics. MitoFit Preprint Arch 2019.2.v2. https://doi.org/10.26124/mitofit:190002.v2 |
Lemieux 2019 bioRxiv | 2019 | Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 . |
Chabi 2019 MitoFit Preprint Arch EA | 2019 | Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. MitoFit Preprint Arch EA19.1. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001 |
Haschka 2018 Mov Disord | 2018 | Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G (2018) Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome. Mov Disord 34:114-23. |
Doerrier 2018 Methods Mol Biol | 2018 | Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70. https://doi.org/10.1007/978-1-4939-7831-1_3 |
Fischer 2018 BMC Musculoskelet Disord | 2018 | Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH (2018) Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry. BMC Musculoskelet Disord 19:388. |
Chicco 2018 J Biol Chem | 2018 | Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC (2018) Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem 293:6659-71. |
Burtscher 2018 Front Mol Neurosci | 2018 | Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C (2018) Proenkephalin derived peptides are involved in the modulation of mitochondrial respiratory control during epileptogenesis. Front Mol Neurosci doi:10.3389/fnmol.2018.00351. |
Komlodi 2018 Methods Mol Biol | 2018 | Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55. https://doi.org/10.1007/978-1-4939-7831-1_8 |
Oemer 2018 Proc Nat Acad Sci U S A | 2018 | Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63. |
Weber 2018 Int J Mol Sci | 2018 | Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129. |
Gatterer 2018 J Sports Sci Med | 2018 | Gatterer H, Menz V, Salazar-Martinez E, Sumbalova Z, Garcia-Souza LF, Cizmarova B, Gnaiger E, Burtscher M (2018) Exercise performance, muscle oxygen extraction and blood cell mitochondrial respiration after repeated-sprint and sprint interval training in hypoxia: a pilot study. J Sports Sci Med 17:339-347. |
Sumbalova 2018 Nova Sciences | 2018 | Sumbalová Z, Garcia-Souza LF, Cizmarova B, Volani C, Gnaiger E (2018) Analysis of mitochondrial function in human blood cells. In: Recent advances in mitochondrial medicine and coenzyme Q10. Gvozdjáková A, Cornelissen G, Singh RB eds, Nova Sciences:255-68. |
Volani 2017 Metallomics | 2017 | Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G (2017) Dietary iron loading negatively affects liver mitochondrial function. Metallomics 9:1634-44. |
Miller 2017 PLOS ONE | 2017 | Miller B, Hamilton K, Boushel R, Williamson K, Laner V, Gnaiger E, Davis M (2017) Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race. PLOS ONE 12:e0174874. |
Horscroft 2017 Proc Natl Acad Sci U S A | 2017 | Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ (2017) Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci U S A 114:6382–7. https://doi.org/10.1073/pnas.1700527114 |
Lemieux 2017 Sci Rep | 2017 | Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. doi:10.1038/s41598-017-02789-8 |
Cabrera-Fuentes 2016 Basic Res Cardiol | 2016 | Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT (2016) From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Res Cardiol 111:69. |
Schoepf 2016 FEBS J | 2016 | Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J 283:2181-96. https://doi.org/10.1111/febs.13733 |
Blatzer 2015 Antioxid Redox Signal | 2015 | Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D (2015) Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal 23:1424-38. https://doi.org/10.1089/ars.2014.6220 |
Gnaiger 2015 Scand J Med Sci Sports | 2015 | Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. https://doi.org/10.1111/sms.12612 |
Boushel 2015 Scand J Med Sci Sports | 2015 | Boushel R, Gnaiger E, Larsen FJ, Helge JW, Gonzalez-Alonso J, Ara I, Munch-Andersen T, van Hall G, Søndergaard H, Saltin B, Calbet JAL (2015) Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity. Scand J Med Sci Sports 25 (Suppl 4):135–43. |
Harrison 2015 J Appl Physiol | 2015 | Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol 119:1210-8. https://doi.org/10.1152/japplphysiol.00146.2015 |
Makrecka-Kuka 2015 Biomolecules | 2015 | Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38. https://doi.org/10.3390/biom5031319 |
Krumschnabel 2015 Methods Mol Biol | 2015 | Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61. https://doi.org/10.1007/978-1-4939-2257-4_22 |
Burtscher 2015 Mitochondrion | 2015 | Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12. |
Dueregger 2015 PLoS One | 2015 | Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704. |
Chicco 2014 J Exp Biol | 2014 | Chicco AJ, Le CH, Schlater AE, Nguyen AD, Kaye SD, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, Crocker DE, Kanatous SB (2014) High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria. J Exp Biol 217:2947-55. |
Krumschnabel 2014 Methods Enzymol | 2014 | Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81. https://doi.org/10.1016/B978-0-12-416618-9.00009-1 |
Gnaiger 2014 MitoPathways | 2014 | Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp. — see 5th edition: Gnaiger 2020 BEC MitoPathways. |
Odra Noel 2014 MiPNet | 2014 | Odra Noel, Gnaiger E (2014) MiPArt - Mitchell's dream - Mitchell's equation. MiPNet 19.13:6-8. |
Larsen 2014 Anal Biochem | 2014 | Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F (2014) The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry? Anal Biochem 446:64-8. |
Boushel 2014 Acta Physiol (Oxf) | 2014 | Boushel RC, Ara I, Gnaiger E, Helge JW, Gonzalez-Alonzo J, Munck-Andersen T, Sondergaard H, Damsgaard R, van Hall G, Saltin B, Calbet JA (2014) Low intensity training increases peak arm VO2 by enhancing both convective and diffusive O2 delivery. Acta Physiol (Oxf) 211:122-34. |
Jacobs 2013 Exp Physiol | 2013 | Jacobs R, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2013) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 98:245-55. |
Iyer 2012 Hum Gene Ther | 2012 | Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr (2012) Mitochondrial gene therapy improves respiration, biogenesis and transcription in G11778A Leber’s hereditary optic neuropathy and T8993G Leigh’s syndrome cells. Hum Gene Ther 23:647-57. |
Burtscher 2012 High Alt Med Biol | 2012 | Burtscher M, Gnaiger E, Burtscher J, Nachbauer W, Brugger A (2012) Arnold Durig (1872-1961): life and work. An Austrian pioneer in exercise and high altitude physiology. High Alt Med Biol 13:224-31. |
Pesta 2012 Methods Mol Biol | 2012 | Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 810:25-58. https://doi.org/10.1007/978-1-61779-382-0_3 |
Gnaiger 2012 MitoPathways | 2012 | Gnaiger E (2012) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 3rd ed. Mitochondr Physiol Network 17.18. Oroboros MiPNet Publications, Innsbruck:64 pp. ISBN 978-3-9502399-6-6 (see 5th edition: Gnaiger 2020 BEC MitoPathways). |
Robach 2012 Br J Sports Med | 2012 | Robach P, Siebenmann C, Jacobs R, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Diaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO2max following normobaric live high-train low in endurance-trained athletes. Br J Sports Med Jul 12. 46:822-7. |
Larsen 2012 CryoLetters | 2012 | Larsen S, Wright-Paradis C, Gnaiger E, Helge JW, Boushel RC (2012) Cryopreservation of human skeletal muscle impairs mitochondrial function. Cryo Letters 33:170-6. |
Votion 2012 PLoS One | 2012 | Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7:e34890. https://doi.org/10.1371/journal.pone.0034890 |
Boushel 2011 Mitochondrion | 2011 | Boushel RC, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B (2011) Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion 11:303-7. |
Lemieux 2011 Int J Biochem Cell Biol | 2011 | Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38. https://doi.org/10.1016/j.biocel.2011.08.008 |
Pesta 2011 Am J Physiol Regul Integr Comp Physiol | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87. |
Kristiansen 2011 J Biol Chem | 2011 | Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem 286:43417-28. https://doi.org/10.1074/jbc.M111.227553 |
Jacobs 2011 J Appl Physiol | 2011 | Jacobs R, Rasmussen P, Siebenmann C, Díaz V, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C (2011) Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 111:1422–30. |
Eberhart 2011 Biochim Biophys Acta | 2011 | Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25. |
Aguirre 2010 Biochim Biophys Acta | 2010 | Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65. https://doi.org/10.1016/j.bbabio.2010.01.033 |
Smolkova 2010 J Bioenerg Biomembr | 2010 | Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Ježek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr 42:55-67. https://doi.org/10.1007/s10863-009-9267-x |
Sjoevall 2010 Crit Care | 2010 | Sjoevall F, Morota S, Hansson Magnus J, Friberg H, Gnaiger E, Elmer E (2010) Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14:R214. |
Sommer 2010 Eur Respir J | 2010 | Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N (2010) Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur Respir J 36:1056-66. https://doi.org/10.1183/09031936.00013809 |
Kozlov 2010 Inflammation | 2010 | Kozlov AV, van Griensven M, Haindl S, Kehrer I, Duvigneau JC, Hartl RT, Ebel T, Jafarmadar M, Calzia E, Gnaiger E, Redl H, Radermacher P, Bahrami Sl (2010) Peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney. Inflammation 33:295-305. |
Scandurra 2010 Adv Exp Med Biol | 2010 | Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662:7-25. https://doi.org/10.1007/978-1-4419-1241-1_2 |
Gnaiger 2009 Int J Biochem Cell Biol | 2009 | Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45. https://doi.org/10.1016/j.biocel.2009.03.013 |
Gnaiger 2009 OCESHS | 2009 | Gnaiger E (2009) Open and closed systems: Styles of thinking explain controversies on the 'Negative Entropy' concept of Ludwig Boltzmann and Erwin Schrödinger. Third ICESHS, Austrian Academy of Sciences, Vienna 2008. |
Gnaiger 2008 POS | 2008 | Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial dysfunction in drug-induced toxicity (Dykens JA, Will Y, eds) John Wiley & Sons, Inc, Hoboken, NJ:327-52. |
Rostrup M 2008 Amino Acids | 2008 | Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J (2008) Oxygen dependence of tyrosine hydroxylase. Amino Acids 34:455-64. |
Aragones 2008 Nat Genet | 2008 | Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger Erich, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80. |
Schneeberger 2008 Shock | 2008 | Schneeberger S, Kuznetsov AV, Seiler R, Renz O, Meusburger H, Mark W, Brandacher G, Margreiter R, Gnaiger E (2008) Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions. Shock 30:365-71. |
Gnaiger 2007 MitoPathways | 2007 | Gnaiger E ed (2007) Mitochondrial pathways and respiratory control. 1st ed. Oroboros MiPNet Publications, Innsbruck:96 pp. ISBN 978-3-9502399-0-4. — see 5th edition: Gnaiger 2020 BEC MitoPathways. |
Boushel 2007 Diabetologia | 2007 | Boushel RC, Gnaiger E, Schjerling P, Skovbro M, Kraunsoee R, Dela F (2007) Patients with Type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6. |
Huetter 2006 Exp Gerontol | 2006 | Hütter E, Unterluggauer H, Garedew A, Jansen-Dürr P, Gnaiger E (2006) High-resolution respirometry - a modern tool in aging research. Exp Gerontol 41:103-9. |
Stadlmann 2006 Cell Biochem Biophys | 2006 | Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ß treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86. |
Cadenas 2006 Biochim Biophys Acta | 2006 | Aguirre E, Rodriguez-Juarez F, Gnaiger E, Cadenas S (2006) Measurement of the control of cellular respiration by nitric oxide under normoxia and hypoxia: instrumental comparison including high-resolution respirometry. Biochim Biophys Acta, EBEC Short Reports Suppl 14:136-7. |
Garedew 2005 Eur Shock Soc | 2005 | Garedew A, Hütter E, Haffner B, Gradl P, Gradl L, Jansen-Dürr P, Gnaiger E (2005) High-resolution respirometry for the study of mitochondrial function in health and disease. The Oroboros O2k. Proc 11th Congress Eur Shock Soc, Vienna, Austria (Redl H, ed) Medimond, Bologna:107-11. |
Huetter 2004 Biochem J | 2004 | Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28. https://doi.org/10.1042/BJ20040095 |
Brunmair 2004 Diabetes | 2004 | Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, Roden M, Gnaiger E, Nohl H, Waldhäusl W, Fürnsinn C (2004) Thiazolidinediones, like metformin, inhibit respiratory Complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 53:1052-9. |
Kuznetsov 2004 Am J Physiol Heart Circ Physiol | 2004 | Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286:H1633–41. |
Pecina 2004 Am J Physiol Cell Physiol | 2004 | Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8. |
Renner 2003 Biochim Biophys Acta | 2003 | Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23. https://doi.org/10.1016/s0167-4889(03)00105-8 |
Gnaiger 2003 Adv Exp Med Biol | 2003 | Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543:39-55. https://doi.org/10.1007/978-1-4419-8997-0_4 |
Steininger 2002 J Antimicrob Chemother | 2002 | Steininger C, Allerberger F, Gnaiger E (2002) Clinical significance of inhibition kinetics in Streptococcus pyogenes in response to penicillin. J Antimicrob Chemother 50:517-23. https://doi.org/10.1093/jac/dkf174 |
Stadlmann 2002 Transplantation | 2002 | Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3. |
Kuznetsov 2002 Anal Biochem | 2002 | Kuznetsov AV, Strobl D, Ruttmann E, Königsrainer A, Margreiter R, Gnaiger E (2002) Evaluation of mitochondrial respiratory function in small biopsies of liver. Anal Biochem 305:186-94. |
Gnaiger 2002 Biochem Soc Trans | 2002 | Gnaiger E, Kuznetsov AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30:242-8. |
Renner 2002 Mol Biol Rep | 2002 | Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101. |
Huetter 2002 Mol Biol Rep | 2002 | Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7. |
Gnaiger 2001 Respir Physiol | 2001 | Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128:277-97. https://doi.org/10.1016/S0034-5687(01)00307-3 |
Kuznetsov 2000 Transplant Proc | 2000 | Kuznetsov AV, Brandacher G, Steurer W, Margreiter R, Gnaiger E (2000) Isolated rat heart mitochondria and whole heart as models for mitochondrial cold ischemia-reperfusion injury. Transplant Proc 32:45. |
Gnaiger 2000 Life in the Cold | 2000 | Gnaiger E, Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Steurer W, Margreiter R (2000) Mitochondria in the cold. In: Life in the Cold (Heldmaier G, Klingenspor M, eds) Springer, Berlin, Heidelberg:431-42. https://doi.org/10.1007/978-3-662-04162-8_45 |
Gnaiger 2000 Transpl Int | 2000 | Gnaiger E, Kuznetsov AV, Rieger G, Amberger A, Fuchs A, Stadlmann S, Eberl T, Margreiter R (2000) Mitochondrial defects by intracellular calcium overload versus endothelial cold ischemia/reperfusion injury. Transpl Int 13:S555-7. |
Gnaiger 2000 Transplant Proc | 2000 | Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14. |
Gnaiger 2000 Proc Natl Acad Sci U S A | 2000 | Gnaiger E, Méndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97:11080-5. https://doi.org/10.1073/pnas.97.20.11080 |
Oexle 1999 Biochim Biophys Acta | 1999 | Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413:99-107. |
Steurer 1999 Transplant Proc | 1999 | Steurer W, Stadlmann S, Roberts K, Fischer M, Margreiter R, Gnaiger E (1999) Quality assessment of isolated pancreatic rat islets by high-resolution respirometry. Transplant Proc 31:650. |
Kuznetsov 1999 Transplant Proc | 1999 | Kuznetsov AV, Brandacher G, Steurer W, Margreiter R, Gnaiger E (1999) Estimation of mitochondrial damage in heart preservation. Transplant Proc 31:992. |
Gnaiger 1999 Transplant Proc | 1999 | Gnaiger E, Rieger G, Stadlmann S, Amberger A, Eberl T, Margreiter R (1999) Mitochondrial defect in endothelial cold ischemia/reperfusion injury. Transplant Proc 31:994-5. |
Gnaiger 1998 Biochim Biophys Acta | 1998 | Gnaiger E, Lassnig B, Kuznetsov AV, Margreiter R (1998) Mitochondrial respiration in the low oxygen environment of the cell: Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1365:249-54. https://doi.org/10.1016/S0005-2728(98)00076-0 |
Gnaiger 1998 J Exp Biol | 1998 | Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control, and excess capacity of cytochrome c oxidase. https://doi.org/10.1242/jeb.201.8.1129 |
Kuznetsov 1998 BTK | 1998 | Kuznetsov AV, Lassnig B, Margreiter R, Gnaiger E (1998) Diffusion limitation of oxygen versus ADP in permeabilized muscle fibers. In BioThermoKinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:273-6. |
Gnaiger 1998 BTK-HRR | 1998 | Gnaiger E, Kuznetsov AV, Lassnig B, Fuchs A, Reck M, Renner K, Stadlmann S, Rieger G, Margreiter R (1998) High-resolution respirometry. Optimum permeabilization of the cell membrane by digitonin. In BioThermoKinetics in the Post Genomic Era (Larsson C, Pahlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:89-95. |
Gnaiger 1998 BTK-COX | 1998 | Gnaiger E, Kuznetsov AV, Lassnig B, Margreiter R (1998) Functional interpretation of the flux control coefficient and excess capacity of cytochrome c oxidase at intracellular oxygen. In BioThermo-Kinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:81-8. |
Sperl 1997 Mol Cell Biochem | 1997 | Sperl W, Skladal D, Gnaiger E, Wyss M, Mayr U, Hager J, Gellerich FN (1997) High resolution respirometry of premeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders. Mol Cell Biochem 174:71-8. |
Gnaiger 1997 Transplant Proc | 1997 | Gnaiger E, Rieger G, Kuznetsov A, Fuchs A, Stadlmann S, Lassnig B, Hengster P, Eberl T, Margreiter R (1997) Mitochondrial ischemia-reoxygenation injury and plasma membrane integrity in human endothelial cells. Transplant Proc 29:3524-6. |
Steinlechner-Maran 1997 Transplantation | 1997 | Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42. |
Steinlechner-Maran 1996 Am J Physiol Cell Physiol | 1996 | Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61. https://doi.org/10.1152/ajpcell.1996.271.6.C2053 |
Gnaiger 1996 BTK-441 | 1996 | Gnaiger E, Reck M, Steinlechner-Maran R, Rieger G, Stadlmann S, Margreiter R (1996) High resolution - the decisive difference in mitochondrial and cellular respirometry. In BioThermoKinetics of the Living Cell (Westerhoff HV, Snoep JL, Wijker JE, Sluse FE, Kholodenko BN, eds), BioThermo-Kinetics, Amsterdam:441-2. |
Gnaiger 1995 J Bioenerg Biomembr | 1995 | Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. https://doi.org/10.1007/BF02111656 |
Gellerich 1995 HRR | 1995 | Gellerich FN, Skladal D, Schranzhofer R, Lanznaster N, Kunz WS, Wisniewski E, Kuznetsov A, Krishmer M, Gnaiger E, Margreiter R, Sperl W (1995) Hochauflösende Respirometrie und multiple Substrat/Inhibitor-Titration zum funktionellen Nachweis mitochondrialer Defekte in permeabilisierten Muskelfasern. In: Molekulare Grundlage hereditärer Myopathien. (Gross M, Gresser U, Hrsg), Zuckschwerdt Verlag, München, Bern, Wien, New York:52-66. |
Gnaiger 1994 BTK-207 | 1994 | Gnaiger E, Wyss M (1994) Chemical forces in the cell: Calculation for the ATP system. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:207-12. |
Gnaiger 1994 BTK | 1994 | Gnaiger E, Gellerich FN, Wyss M (1994) What is controlling life? 50 years after Erwin Schrödinger's What is life? Modern trends in BiothermoKinetics 3, Innsbruck Univ Press:336 pp. ISBN 10: 3901249176, ISBN 13: 9783901249174 |
Sperl 1994 J Inher Metab Dis | 1994 | Sperl W, Skladal D, Lanznaster N, Schranzhofer R, Zaunschirm G, Gnaiger E, Gellerich FN (1994) Polarographic studies of saponin-skinned muscle fibers in patients with mitochondrial myopathies. J Inher Metab Dis 17:307-10. |
Haller 1994 Anal Biochem | 1994 | Haller T, Ortner M, Gnaiger E (1994) A respirometer for investigating oxidative cell metabolism. Toward optimization of respiratory studies. Anal Biochem 218:338-42. |
Gnaiger 1994 BTK-62 | 1994 | Gnaiger E (1994) Negative entropy for living systems: controversy between Nobel Laureates Schrödinger, Pauling and Perutz. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press: 62-70. |
Knoblechner 1994 BTK-294 | 1994 | Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6. |
Eberl 1994 BTK-288 | 1994 | Eberl T, Steinlechner R, Salvenmoser W, Abendstein B, Rhomberg M, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (1994) Endothelial cell cultures as a model for organ preservation studies. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:288-93. |
SteinlechnerMaran 1994 BTK-283 | 1994 | Steinlechner-Maran R, Eberl T, Margreiter R, Gnaiger E (1994) Oxygen dependence of cellular respiration in endothelial cells: A sensitive toxicological test. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:283-7. |
Skladal 1994 BTK-268 | 1994 | Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN (1994) Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:268-71. |
Gellerich 1994 BTK-263 | 1994 | Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E (1994) Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:263-7. |
Kemp 1994 BTK-226 | 1994 | Kemp RB, Hoare S, Schmalfeldt M, Bridge ChMC, Evansa PM, Gnaiger E (1994) A thermochemical study of the producion of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:226-31. |
Mendez 1994 BTK-191 | 1994 | Méndez G, Gnaiger E (1994) How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:191-4. |
Laterveer 1994 BTK-186 | 1994 | Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K (1994) Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:186-90. |
Gellerich 1994 BTK-181 | 1994 | Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K (1994) Effect of macromolecules on ADP-transport into mitochondria. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:181-5. |
Gnaiger 1993 Transitions | 1993 | Gnaiger E (1993) Homeostatic and microxic regulation of respiration in transitions to anaerobic metabolism. In: The vertebrate gas transport cascade: Adaptations to environment and mode of life. Bicudo JEPW (ed), CRC Press, Boca Raton, Ann Arbor, London, Tokyo:358-70. |
Gnaiger 1993 Pure Appl Chem | 1993 | Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002. http://dx.doi.org/10.1351/pac199365091983 |
Gnaiger 1993 Hypoxia | 1993 | Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving hypoxia: Mechanisms of control and adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109. |
Gustafsson 1993 Pure Appl Chem | 1993 | Gustafsson L, Kemp R, Gnaiger E (1993) Preface: Calorimetry and thermodynamics of biological processes. Pure Appl Chem 65:IV. |
Buck 1993 Am J Physiol Regul Integr Comp Physiol | 1993 | Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol Regul Integr Comp Physiol 265:R1014-9. |
Von Stockar 1993 Biochim Biophys Acta | 1993 | Von Stockar U, Gustafsson L, Larsson C, Marison I, Tissot P, Gnaiger E (1993) Thermodynamic considerations in constructing energy balances for cellular growth. Biochim Biophys Acta 1183:221-40. https://doi.org/10.1016/0005-2728(93)90225-5 |
Doeller 1993 J Exp Zool | 1993 | Doeller JE, Kraus DW, Shick JM, Gnaiger E (1993) Heat flux, oxygen flux and mitochondrial redox state as a function of oxygen availability and ciliary beat activity in isolated gills of Mytilus edulis. J Exp Zool 265:1-8. |
Gnaiger 1993 Verh Dtsch Zool Ges | 1993 | Gnaiger E (1993) Adaptations to winter hypoxia in a shallow alpine lake. Ecophysiological energetics of Cyclops abyssorum and rainbow trout. Verh Dtsch Zool Ges 86:43-65. |
Gnaiger 1993 Respiratorische Therapie nach operativen Eingriffen | 1993 | Gnaiger E (1993) Zelluläre und mitochondriale Adaptationsvorgänge bei Hypoxie. In: Rügheimer E (ed) Respiratorische Therapie nach operativen Eingriffen. Springer 3-16. |
Gnaiger 1992 Funct Ecol | 1992 | Gnaiger E (1992) Optimum efficiency of energy transformation and the evolution of catabolic pathways. Funct Ecol 6:234-41. |
Gnaiger 1991 Soc Exp Biol Seminar Series | 1991 | Gnaiger E (1991) Animal energetics at very low oxygen: Information from calorimetry and respirometry. In: Strategies for gas exchange and metabolism. Woakes R, Grieshaber M, Bridges CR (eds), Soc Exp Biol Seminar Series 44, Cambridge Univ Press, London:149-71. |
Raich 1990 CYCLOBIOS | 1990 | Raich K, Haller T, Gnaiger E (1990) The kinetics of mitochondria isolated from oligochaetes: Comparison with classical rat liver mitochondria. CYCLOBIOS Newsletter 4:77-9. |
Schoen 1990 Cyclobios | 1990 | Schön A, Haller T, Gnaiger E (1990) Hexokinase induced, steady state coupled mitochondria studied by injection calorimetry and respirometry. CYCLOBIOS Newsletter 4:67-72. |
Haller 1990 CYCLOBIOS Kinetics | 1990 | Haller T, Gnaiger E (1990) Kinetic control and reaction pressure in steady state coupled mitochondria. CYCLOBIOS Newsletter 4:63-6. |
Gnaiger 1990 CYCLOBIOS | 1990 | Gnaiger E, Steinlechner R, Doeller JE, Haller T, eds (1990) Calorimetry, Respirometry and Mitochondrial Energetics. CYCLOBIOS Newsletter 4:93 pp. |
Gnaiger 1990 Biochim Biophys Acta | 1990 | Gnaiger E, Kemp RB (1990) Anaerobic metabolism in aerobic mammalian cells: information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim Biophys Acta 1016:328-32. https://doi.org/10.1016/0005-2728(90)90164-y |
Byrne 1990 Biol Bull | 1990 | Byrne RA, Gnaiger E, McMahon RF, Diez TH (1990) Behavioral and metabolic responses to emersion and subsequent reimmersion in the freshwater bivalve, Corbicula fluminea. Biol Bull 178:251-9. |
Liu 1990 Mar Biol | 1990 | Liu LL, Stickle WB, Gnaiger E (1990) Normoxic and anoxic energy metabolism of the southern oyster drill Thais haemastoma during salinity acclimation. Mar Biol 104:239-45. https://doi.org/10.1007/BF01313264. |
Doeller 1990 Thermochim Acta | 1990 | Doeller JE, Kraus DW, Gnaiger E, Shick JM (1990) Calorespirometry and spectrophotometry of the ciliated gill of the marine mussel Mytilus edulis. Thermochim Acta 172:171-8. |
Gurakan 1990 Thermochim Acta | 1990 | Gurakan T, Marison IW, von Stockar U, Gustafsson L, Gnaiger E (1990) Proposals for a standardized sample handling procedure for the determination of elemental composition and enthalpy of combustion of biological material. Thermochim Acta 172:251-66. |
Gnaiger 1990 Thermochim Acta | 1990 | Gnaiger E (1990) Concepts on efficiency in biological calorimetry and metabolic flux control. Thermochim Acta 172:31-52. https://doi.org/10.1016/0040-6031(90)80557-F |
Gnaiger 1989 Energy Transformations | 1989 | Gnaiger E (1989) Mitochondrial respiratory control: energetics, kinetics and efficiency. In: Energy transformations in cells and organisms. Wieser W, Gnaiger E (eds), Thieme, Stuttgart:6-17. |
Kemp 1989 Energy transformations | 1989 | Kemp RB, Gnaiger E (1989) Aerobic and anaerobic energy metabolism in cultured cells. In: Energy transformations in cells and organisms'. Wieser W, Gnaiger E (eds), Thieme, Stuttgart:91-7. |
Gnaiger 1989 Soc Exp Biol Seminar Series | 1989 | Gnaiger E, Shick JM, Widdows J (1989) Metabolic microcalorimetry and respirometry of aquatic animals. In: Techniques in comparative respiratory physiology. An experimental approach. Bridges CR, Butler PJ (eds), Soc Exp Biol Seminar Series, Cambridge Univ Press, London:113-35. |
Gnaiger 1989 Thermochim Acta | 1989 | Gnaiger E (1989) Physiological calorimetry: heat flux, metabolic flux, entropy and power. Thermochim Acta 151:23-34. https://doi.org/10.1016/0040-6031(89)85334-1 |
Stickle 1989 Biol Bull | 1989 | Stickle WB, Kapper MA, Liu LL, Gnaiger E, Wang SY (1989) Metabolic adaptations of several species of crustaceans and molluscs to hypoxia: tolerance and microcalorimetric studies. Biol Bull 177:303-12. |
Hand 1989 Thieme | 1989 | Hand SC, Gnaiger E (1989) Metabolic arrest in Artemia embryos quantified with microcalorimetric, respirometric and biochemical measurements. In: Energy transformations in cells and organisms. Wieser W, Gnaiger E (eds), Thieme, Stuttgart:155-62. |
Hand 1988 Science | 1988 | Hand SC, Gnaiger E (1988) Anaerobic dormancy quantified in Artemia embryos: A calorimetric test of the control mechanism. Science 239:1425-7. |
Shick 1988 Amer Zool | 1988 | Shick JM, Widdows J, Gnaiger E (1988) Calorimetric studies of behavior, metabolism and energetics of sessile intertidal animals. https://doi.org/10.1093/icb/28.1.161. |
Gnaiger 1987 Hydrobiol | 1987 | Gnaiger E, Kaufmann R, Staudigl I (1987) Physiological reactions of aquatic oligochaetes to environmental anoxia. Hydrobiol 155:155. |
Gnaiger 1987 Physiol Zool | 1987 | Gnaiger E, Staudigl I (1987) Aerobic metabolism and physiological responses of aquatic oligochaetes to environmental anoxia. Heat dissipation, oxygen consumption, feeding and defecation. Physiol Zool 60:659-77. |
Shick 1986 Physiol Zool | 1986 | Shick JM, Gnaiger E, Widdows J, Bayne BL, De Zwaan A (1986) Activity and metabolism in the mussel Mytilus edulis L. during intertidal hypoxia and aerobic recovery. Physiol Zool 59:627-42. |
Putzer 1985 Comp Biochem Physiol | 1985 | Putzer V, Gnaiger E, Lackner R (1985) Flexibility of anaerobic metabolism in aquatic oligochaetes (Tubifex sp.). Biochemical and calorimetric changes induced by a deproteinized hydrolysate of bovine blood. Comp Biochem Physiol 82A:965-70. |
Hawkins 1985 Mar Ecol Prog Ser | 1985 | Hawkins AJS, Salkeld PN, Bayne BL, Gnaiger E, Lowe DM (1985) Feeding and resource allocation in the mussel Mytilus edulis: evidence for time-averaged optimization. Mar Ecol Prog Ser 20:273-87. |
Bitterlich 1984 Aquaculture | 1984 | Bitterlich G, Gnaiger E (1984) Phytoplanktivorous or omnivorous fish? Digestibility of zooplankton by silvercarp, Hypophthalmichthys molitrix (Val.). Aquaculture 40:261-3. |
Gnaiger 1984 Oecologia | 1984 | Gnaiger E, Bitterlich G (1984) Proximate biochemical proposition and caloric content calculated from elemental CHN analysis: a stoichiometric concept. Oecologia 62:289-98. |
Gnaiger 1983 POS-pO2 | 1983 | Gnaiger E (1983) Calculation of pO2 in water equilibrated with a mixture of room air and nitrogen. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:334-6. |
Hitchman 1983 POS Membrane | 1983 | Hitchman ML, Gnaiger E (1983) A thermodynamic consideration of permeability coefficients of membranes. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:31-6. |
Gnaiger 1983 POS-EnergEquivalents | 1983 | Gnaiger E (1983) Calculation of energetic and biochemical equivalents of respiratory oxygen consumption. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:337-45. |
Gnaiger 1983 POS-in situ | 1983 | Gnaiger E (1983) In situ measurement of oxygen profiles in lakes: microstratifications, oscillations, and the limits of comparison with chemical methods. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:245-64. |
Gnaiger 1983 Springer POS | 1983 | Gnaiger E, Forstner H, eds (1983) Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Springer, Berlin, Heidelberg, New York:370 pp. https://link.springer.com/book/10.1007/978-3-642-81863-9 |
Forstner 1983 POS | 1983 | Forstner H, Gnaiger E (1983) Calculation of equilibrium oxygen concentration. In: Gnaiger E, Forstner H (eds) Polarographic oxygen sensors. Aquatic and physiological applications. Springer, Berlin, Heidelberg, New York:321-33. |
Gnaiger 1983 J Exp Zool | 1983 | Gnaiger E (1983) Heat dissipation and energetic efficiency in animal anoxibiosis. Economy contra power. J Exp Zool 228:471-90. |
Gnaiger 1983 POS preface | 1983 | Gnaiger E (1983) Preface: A biologist´s view. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:V-VII. https://link.springer.com/book/10.1007/978-3-642-81863-9 |
Gnaiger 1983 POS symbols | 1983 | Gnaiger E (1983) Symbols and units: toward standardization. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:352-8. |
Gnaiger 1983 Twin-Flow | 1983 | Gnaiger E (1983) The twin-flow microrespirometer and simultaneous calorimetry. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:134-66. |
Gnaiger 1983 Sci Tools | 1983 | Gnaiger E (1983) Microcalorimetric monitoring of biological activities: Ecological and toxicological studies with aquatic animals. Sci Tools 30:21-6. |
Kaufmann 1981 Thermochim Acta | 1981 | Kaufmann R, Gnaiger E (1981) Optimization of calorimetric systems: continuous control of baseline stability by monitoring thermostat temperatures. Thermochim Acta 49:75-85. |
Gnaiger 1981 Thermochim Acta | 1981 | Gnaiger E (1981) Pharmacological application of animal calorimetry. Thermochim Acta 49:75-85. |
Gnaiger 1980 Thermal Analysis, Birkhaeuser | 1980 | Gnaiger E (1980) Direct and indirect calorimetry in the study of animal anoxibiosis. A review and the concept of ATP-turnover. Thermal Analysis, Proc 6th Internat Conference Thermal Analysis, Birkhäuser:547-52. |
Gnaiger 1980 Thermochim Acta | 1980 | Gnaiger E (1980) Das kalorische Äquivalent des ATP-Umsatzes im aeroben und anoxischen Metabolismus. Thermochim Acta 40:195-223. https://doi.org/10.1016/0040-6031(80)87186-3 |
Gnaiger 1980 FEBS Lett | 1980 | Gnaiger E (1980) Energetics of invertebrate anoxibiosis: direct calorimetry in aquatic oligochaetes. FEBS Lett 112:239-42. |
Gnaiger 1979 Experientia | 1979 | Gnaiger E (1979) Long term monitoring of aquatic animals. Experientia Suppl 37:155-65. doi: 10.1007/978-3-0348-5545-7_23. |
Gnaiger 1978 Limnol Oceanogr | 1978 | Gnaiger E, Gluth G, Wieser W (1978) pH fluctuation in an intertidal beach in Bermuda. https://doi.org/10.4319/lo.1978.23.5.0851 |
Gnaiger 1977 Invertebrate anoxibiosis | 1977 | Gnaiger E (1977) Thermodynamic considerations of invertebrate anoxibiosis. In: Applications of calorimetry in life sciences. Lamprecht I, Schaarschmidt B (eds), de Gruyter, Berlin:281-303. |
Wieser 1974 Mar Biol | 1974 | Wieser W, Ott J, Schiemer F, Gnaiger E (1974) An ecophysiological study of some meiofauna species inhabiting a sandy beach at Bermuda. Mar Biol 26:235-48. |
Abstracts
Published | Reference | |
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Sobotka 2024 EBEC | 2024 | Sobotka O, Cardoso L, Garcia-Souza L, Sobotka L, Gnaiger E (2024) The effect of glucose on mitochondrial respiration in hepatocellular carcinoma cells. EBEC 2024. |
Donnelly 2024 EU-METAHEART MC2 Meeting | 2024 | Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Kayser B, Place N, Gnaiger E (2024) Functional hypoxia in cardiac mitochondria: effects on oxidative phosphorylation, mitochondrial membrane potential, redox state of coenzyme Q, and calcium uptake. EU-METAHEART MC2 Meeting 2024 Antalya TR. |
Baglivo 2023 ESCI Prague | 2023 | Baglivo E, Timon-Gomez A, Gnaiger E (2023) The cytochrome c test for respirometric quality control of the integrity of the mitochondrial outer membrane. 57th Annual Scientific Meeting of the European Society for Clinical Investigation. |
Cardoso 2023 BPS2023 San Diego | 2023 | Cardoso LHD, Timon-Gomez A, Doerrier C, Garcia-Souza LF, Gnaiger Erich (2023) Respirometric substrate-uncoupler-inhibitor titration protocols for carbohydrate and fatty acid metabolism: from heart to brain mitochondria. 67th Annual Meeting of the Biophysical Society. |
Cecatto 2023 BPS2023 San Diego | 2023 | Cecatto C, Schmitt Sabine, Cardoso L, Videja M, Dambrova M, Makrecka-Kuka M, Liepinsh E, Gnaiger E (2023) Contribution of fatty acid oxidation to respiratory control in brain mitochondria. 67th Annual Meeting of the Biophysical Society. |
Schmitt 2023 BPS2023 San Diego | 2023 | Schmitt S, Cardoso LHD, Cecatto C, Komlodi T, Gnaiger Erich (2023) Mitochondrial bioenergetics – a quantitative analytical and diagnostic approach. 67th Annual Meeting of the Biophysical Society. |
Gnaiger 2023 MiP2023 | 2023 | From globesity to mitObesity. |
Timon-Gomez 2023 EUROMIT2023 Bologna | 2023 | Timon-Gomez A, Cardoso L, Baglivo E, Doerrier C, Gnaiger E (2023) Mitochondrial injury in warm ischemia studied by high-resolution respirometry. EUROMIT2023 International Conference on Mitochondrial Pathology. |
Leo 2023 ESCI Prague | 2023 | Leo E, Zdrazilova L, Garcia-Souza LF, Åsander-Frostner E, Elmér E, Gnaiger E (2023) High-resolution respirometry is comparable in 0.5 mL and 2.0 mL chamber volumes: studies with platelets, permeabilized fibroblasts, and isolated mitochondria. 57th Annual Scientific Meeting of the European Society for Clinical Investigation. |
Timon-Gomez 2023 GIBB | 2023 | Timón-Gómez A, Cardoso LHD, Doerrier C, Garcia-Souza LF, Gnaiger E (2023) A reference substrate-uncoupler-inhibitor titration protocol to create a mitochondrial pathway and coupling control database. Third international GIBB meeting. |
Komlodi 2023 EUROMIT2023 Bologna | 2023 | Komlódi T, Silva FSG, Duarte AI, Mena D, Garcia-Souza LF, Makrecka-Kuka M, Bento G, Grilo LF, Oliveira PJ, Gnaiger E (2023) Off-target effects of etomoxir: inhibition of mitochondrial Complex I and fatty acid oxidation. EUROMIT2023 International Conference on Mitochondrial Pathology. |
Cardoso 2022 Abstract Bioblast | 2022 | 4.3. «10+5» Cardoso Luiza HD, Doerrier C, Donnelly C, Komlódi T, Gnaiger E (2022) Redox monitoring and respiration - a new horizon with the NextGen-O2k. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Molina 2022 Abstract Bioblast | 2022 | 3.2. «10+5» Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina Anthony JA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Bioenergetics Communications« |
Pallag 2022 Abstract Bioblast | 2022 | P06. Pallag Gergely, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« |
Meszaros 2022 Abstract Bioblast | 2022 | 6.6. «5 min» Meszaros Andras T, Hofmann J, Gnaiger E, Oberhuber R, Hautz T, Öfner D, Schneeberger S (2022) Pre-transplant mitochondrial respiration as a clinical prognostic marker during static cold storage and machine perfusion of the liver. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Donnelly 2022 Abstract Bioblast | 2022 | 2.1. «10+5» Donnelly Chris, Schmitt S, Cecatto C, Cardoso L, Komlodi T, Place N, Kayser B, Gnaiger E (2022) The ABC of hypoxia – what is the norm. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« |
Baglivo 2022 Abstract Bioblast | 2022 | 4.1. «10+5» Baglivo Eleonora, Cardoso LHD, Cecatto C, Gnaiger E (2022) Statistical analysis of instrumental reproducibility as internal quality control in high-resolution respirometry. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Bioenergetics Communications« |
Bergmeister 2022 Abstract Bioblast | 2022 | P11. Bergmeister Lisa, Doerrier C, Gnaiger E, Schwarzer C (2022) The role of enkephalin in hypoxic preconditioning. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Garcia-Roves 2022 Abstract Bioblast | 2022 | 4.4. «10+5» Gama-Perez P, Cardoso L, Komlodi K, Bosch N, Gnaiger E, Garcia-Roves Pablo M (2022) Tuning the assessment of coenzyme Q redox state and respiration in permeabilized skeletal muscle fibers. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Cecatto 2022 Abstract Bioblast | 2022 | 5.1. «10+5» Cecatto Cristiane, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Cardoso 2022 Q10 Hamburg | 2022 | Cardoso LHD, Donnelly C, Komlodi T, Gnaiger E (2022) Coenzyme Q redox state and respiration in permeabilized HEK 293T cells: coupling and pathway control. Q10 Hamburg. |
Schmitt 2022 Abstract Bioblast | 2022 | 2.2. «10+5» Schmitt Sabine, Gnaiger E (2022) Using oxygen and hydrogen gas in studies of mitochondrial respiration and hydrogen peroxide production under hyperoxic, normoxic, and hypoxic conditions. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Gnaiger 2022 Abstract Bioblast-PB | 2022 | P03. Went N, Di Marcello M, Gnaiger Erich (2022) Oxygen dependence of photosynthesis and light-enhanced dark respiration studied by high-resolution PhotoRespirometry. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« |
Cardoso 2022 ESCI Bari | 2022 | Cardoso LHD, Donnelly C, Komlódi T, Gnaiger E (2022) Bioenergetic fingerprinting with coupling and pathway control of coenzyme Q redox state and respiration in permeabilized HEK 293T cells. 56th Annual Scientific Meeting of the European Society for Clinical Investigation. |
Porter 2022 Abstract Bioblast | 2022 | 6.3. «10+5» Karavyraki M, Gnaiger E, Porter Richard K (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« |
Schmitt 2022 EBEC | 2022 | Schmitt S, Gnaiger E (2022) Short-term effect of molecular hydrogen on mitochondrial respiration and hydrogen peroxide production in permeabilized HEK 293T cells. EBEC 2022. |
Cecatto 2022 EBEC | 2022 | Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. EBEC 2022. |
Cardoso 2022a EBEC | 2022 | Cardoso LHD, Donnelly C, Komlódi T, Gnaiger E (2022) Characterizing electron transfer through the mitochondrial Q-junction from fatty acid oxidation and TCA cycle on HEK 293T cells: correlation with respiration. EBEC 2022. |
Gnaiger 2022 Abstract Bioblast-eds | 2022 | 1. Gnaiger Erich, Cardoso Luiza HD, Tindle-Solomon Lisa, Cocco Paolo (2022) Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Gnaiger 2022 Abstract Bioblasts | 2022 | 1.01. Gnaiger Erich (2022) Bioblasts - the taxonomic unit of bioenergetics: mitochondria, aerobic bacteria, chloroplasts. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Mitochondr Physiol Network 2010 - a Living Communication« |
Cardoso 2022b EBEC | 2022 | Baglivo E, Cardoso LHD, Cecatto C, Gnaiger E (2022) Instrumental quality control and evaluation of mitochondrial respiration medium in high-resolution respirometry with living and permeabilized cells. EBEC 2022. |
Gnaiger 2020 MiP2020 | 2020 | |
Gnaiger 2020 APS Chicago | 2020 | Gnaiger E (2020) Aerobic exercise capacity and mitochondrial fitness: from muscle to brain. APS2020 Chicago. |
Jusic 2019 ESCI2019 | 2019 | Jusic A, Gnaiger E (2019) Feedback and mutual expectations: COST Action CA15203 MitoEAGLE MC member Bosnia and Herzegovina. |
Ravasz 2019 Abstract IOC141 | 2019 | Ravasz D, Bui D, Kitayev A, Greenwood B, Hill C, Komlodi T, Doerrier C, Ozohanics O, Moore AL, Gnaiger E, Kiebish M, Kolev K, Seyfried TN, Willis WT, Narain N, Adam-Vizi V, Chinopoulos C (2019) Endogenous quinones sustain a moderate NADH oxidation by Complex I during anoxia. Mitochondr Physiol Network 24.02. |
Gnaiger 2018 MiPschool Tromso A1 | 2018 | Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control. |
Gnaiger 2018 MiP2018 | 2018 | Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks of mitochondrial physiology Part 2. |
Gnaiger 2018 MiPschool Tromso A2 | 2018 | The protonmotive force and respiratory control. 1. Coupling of electron transfer reactions to vectorial translocation of protons. 2. From Einstein’s diffusion equation on gradients to Fick’s law on compartments. |
Gnaiger 2018 AussieMit | 2018 | Komlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU. |
Sobotka 2018 MiP2018 | 2018 | Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay. |
Komlodi 2018 EBEC2018 | 2018 | Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool. |
Gnaiger 2017 MiP2017 | 2017 | Gnaiger E (2017) Protonmotive force and chemiosmotic pressure: a generalization of non-ohmic flux control of the proton leak. MiP2017. |
Neururer 2017 Abstract Health Informatics 2017 | 2017 | Developing a standardized minimum dataset for mitochondrial research data – a project outline. |
Komlodi 2017 MiP2017 | 2017 | H2O2 production under hypoxia in brain and heart mitochondria: does O2 concentration matter? |
Neururer 2017 Abstract Global Biobank Week 2017 | 2017 | Extending MIABIS for the development of a standardized minimum dataset for mitochondrial research data. |
Gnaiger 2017 MiPschool A1 | 2017 | Elemental steps towards understanding mitochondrial core energy metabolism: coupling control. |
Gnaiger 2017 MiPschool A4 | 2017 | Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology. |
Gnaiger 2017 MiPschool C1 | 2017 | Apparent Complex IV excess capacity and biochemical thresholds. |
Cizmarova 2017 MiPschool Obergurgl | 2017 | The scope of cryopreservation in blood cells for functional mitochondrial diagnosis. |
Gnaiger 2017 MiPschool C4 | 2017 | Respiratory control ratios and control factors |
Neururer 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | A project to develop a standardized minimum dataset to describe mitochondrial data. |
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II | 2015 | On coupling control of mitochondrial respiration. What is wrong with the RCR? |
Sumbalova 2015 Abstract MiP2015 | 2015 | High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods. |
Gnaiger 2014 Abstract MiP2014 | 2014 | Cell ergometry: OXPHOS and ET-pathway coupling efficiency. |
Gnaiger 2013 MiP2013-Opening | 2013 | Gnaiger E (2013) What is mitochondrial physiology – why comparative? Mitochondr Physiol Network 18.08. |
Meissner 2012 Abstract Bioblast | 2012 | Meissner B, Gnaiger E (2012) Open Innovation. Mitochondr Physiol Network 17.12. |
Leo 2012 Abstract Bioblast | 2012 | Leo H, Gnaiger E (2012) Happiness and mitochrondrial activity. Mitochondr Physiol Network 17.12. |
Kliemt 2012 Abstract Bioblast | 2012 | Kliemt U, Gnaiger E (2012) Power and efficiency: Tempo giusto in classical music, thermodynamics and industrial revolution, and the speed of life. Mitochondr Physiol Network 17.12. |
Burtscher 2011Abstract Mitochondrial Medicine | 2011 | Burtscher M, Dietrich H, Gatterer H, Gnaiger E, Harrison DK, Karall D, Krismer M, Lass-Floerl C, Parson W, Perkhofer S, Pesta D, Schocke M, Sumbalova Z, Wiethüchter A (2011) Mitochondrial competence. Regional and international cooperation for establishing new standards in functional mitochondrial diagnosis. Abstract Mitochondrial Medicine Chicago. |
Gnaiger MiP2010 | 2010 | Gnaiger E, Renner-Sattler K (2010) FEBS Workshop: Mitochondrial Physiology. The Many Functions of the Organism in Our Cells. |
Gnaiger MiP2010 7-03 | 2010 | Gnaiger E (2010) MiPArt exhibition “The Beauty of Mitochondria” |
Wiethuechter MiP2010 | 2010 | Wiethuechter A, Gnaiger E (2010) Bioblast wiki. |
Gnaiger 2005 Abstract MiP2005 | 2005 | Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age. MiP2005. |
MitoEAGLE mentor
CURRICULUM VITAE
Erich Gnaiger
- D. Swarovski Research Laboratory
- Department of Visceral, Transplant and Thoracic Surgery
- Medical University of Innsbruck
- A-6020 Innsbruck, Austria
- Tel: +43 512 5667960
- Email: [email protected]
- Erich Gnaiger is the founder and CEO of the company Oroboros Instruments (www.oroboros.at) with world-wide technological leadership in high-resolution respirometry, reference laboratories in 49 countries, >3,000 O2k-Publications listed on our website, and >1,000 award-winning O2k-FluoRespirometer instruments sold. The cooperation between academia (Medical University of Innsbruck) and industry (Oroboros Instruments) is formalized in a K-Regio Centre of Excellence with the projects MitoCom Tyrol and MitoFit coordinated by Erich Gnaiger. Erich Gnaiger has scientific and technical expertise in the fields of mitochondrial physiology and pathology, microcalorimetry and biological thermodynamics, contributing fundamentally to the understanding of mitochondrial respiratory control by oxygen, and development and application of high-resolution respirometry to cellular bioenergetics and the diagnosis of mitochondrial defects, particularly in relation to hypoxia, cold storage and ischemia-reperfusion injury. He is initiator (2003) and chairman of the International Mitochondrial Physiology Society (MiP; www.mitophysiology.org), and has organized numerous conferences (particularly MiP2003, MiP2005, MiP2010, MiP2013 and MiP2014 in Austria), workshops (more than 130 international O2k-Workshops on high-resolution respirometry), and training courses on mitochondrial physiology, bioenergetics and biological thermodynamics, and is editor of several proceedings of international meetings. The international teaching activities range from thermodynamics of irreversible processes for chemical engineers (EU-level training; member of the IUPAC steering committee on biological thermodynamics) to mitochondrial physiology (Innsbruck Summer School 1991; initiator of the MiPsummer Schools 2007, 2008, 2017 in Austria; 2009 in Louisiana, US; 2010 in Lithuania, 2018 in Normway). Erich Gnaiger is member of the editorial board of the journal ‘Mitochondrion’. He is Chair of the COST Action CA15203 MitoEAGLE (2016-2020).
- Erich Gnaiger is initiator of ‘Gentle Science’ (www.bioblast.at).
- Chairperson of the Mitochondrial Physiology Society
- Academic training
- 1985: Habilitation: Stoichiometric and calorimetric principles of aerobic and anaerobic energy budgets and thermodynamic optimization in metabolic economy: Rate and power, versus efficiency. University of Innsbruck, Department of Zoology.
- 1974-80: University of Innsbruck, graduate, zoophysiology, limnology and biochemistry.
- Ph.D. thesis: Direct calorimetry and bioenergetics: aerobic and anoxic metabolism in aquatic oligochaetes. Dept. Zoology, University of Innsbruck.
- 1974-80: University of Innsbruck, graduate, zoophysiology, limnology and biochemistry.
- 1970-74: University of Vienna, undergraduate, zoology and biochemistry.
- Positions held
- 2017 - Ao. Univ.-Prof. i.R.; D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.
- 1993-2017 Cooperation with Univ.-Prof. Dr. R. Margreiter, initiating and leading the research laboratory associated with the Department of Transplant Surgery, Medical School, University of Innsbruck; Ao.Univ.-Prof.; D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.
- 1999 -Honorary Professor, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.
- 1992-99 Honorary Fellow, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.
- 1989-92 Research position, Austrian Science Foundation FWF and FFF.
- 1986-88 FWF Erwin Schrödinger Fellowship (USA)
- 1985-92 Research Assistant Professor, Dept. Zool., Univ. Innsbruck, Austria.
- 1984-85 Research Assistant and Lecturer, Dept. Zool., Univ. Innsbruck
- 1982-83 Postdoctoral position, Inst. Marine Environ. Research, Plymouth, UK.
- 1980-81 Austrian Science Foundation FWF, postdoctoral associate, Dept. Zool., Univ. Innsbruck.
- 1980-81 Lecturer, Dept. Zool., Univ. Innsbruck.
- 1974-80 Austrian Science Foundation research assistant, Dept. Zool., Univ. Innsbruck.
- Research support: Projects
- COST Action TD0901 HypoxiaNet.
- COST Action FA0602 Mitofood.
- Marsden, Univ. Auckland, New Zealand.
- Austrian Science Foundation, FWF.
- Austrian Science Foundation for Commerce FFF (now FFG).
- Austrian Ministry of Science.
- Austrian Ministry of the Environment.
- Community Action Programme in Education and Training for Technology, COMETT.
- ÖAD Acciones Integradas: Innsbruck-Barcelona; Innsbruck-Madrid.
- Swedish National Science Foundation; co-PI with Dr. L. Gustafsson, Univ Gothenburg, Sweden.
- Erwin-Schrödinger Fellowship, Austria (UK and USA).
- British Council Postdoctoral Fellowship, UK.
- Awards
- 2012 Houska Award 2012 (Vienna, AT, Apr 2012)
- 2003 Lavoisier award of the International Society of Biological Microcalorimetry (Würzburg, DE, Oct 2003)
- 1999 Honorary Professor, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.
Selected publications
Selected conference proceedings / edited books
- Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp. - »Bioblast link«
- Laner V, Gnaiger E, eds (2014) Mitochondrial physiology – methods, concepts and biomedical perspectives. MiP2014. Mitochondr Physiol Network 19.13:88 pp. - »Bioblast link«
- Laner V, Bidaurratzaga E, Gnaiger E, eds (2013) Comparative Mitochondrial Physiology. MiP2013. Mitochondr Physiol Network 18.08:96 pp. - »Bioblast link«
- Gnaiger E, Meissner B, Laner V, eds (2012) Bioblast 2012: Mitochondrial Competence. Mitochondr Physiol Network 17.12. Oroboros MiPNet Publications, Innsbruck: 96 pp. »Open Access
- Renner-Sattler K, Gnaiger E, eds (2010) Mitochondrial physiology. The many functions of the organism in our cells. Mitochondr Physiol Network 15.6: 128 pp. »MiP2010
- Gnaiger E, Gellerich FN, Wyss M, eds (1994) What is Controlling Life? 50 Years after Erwin Schrödinger's What is Life? Modern Trends in BioThermoKinetics 3. Innsbruck Univ. Press, Innsbruck: 336 pp. »Open Access
- Wieser W, Gnaiger E, eds (1989) Energy Transformations in Cells and Organisms. Thieme Publ., Stuttgart: 330 pp.
- Gnaiger E, Forstner H, eds (1983) Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Springer, Berlin, Heidelberg, New York: 370 pp. »Bioblast Access
Selected publications 2010-
- Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J. - »Bioblast link«
- Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. - »Bioblast link«
- Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol Aug 6:jap.00146.2015. doi: 10.1152/japplphysiol.00146.2015. - »Bioblast link«
- Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12. - »Bioblast link«
- Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopsies of human muscle. Methods Mol Biol 810:25-58. - »Bioblast link«
- Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7:e34890. - »Bioblast link«
- Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38. - »Bioblast link«
- Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87. - »Bioblast link«
- Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: Facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662:7-25. - »Bioblast link«
12 Selected Publications: 2000-2009
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837–45. - »Bioblast link«
- Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80. - »Bioblast link«
- Boushel R, Gnaiger E, Schjerling P, Skovbro M, Kraunsøe R, Dela F (2007) Patients with Type 2 Diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6. - »Bioblast link«
- Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxydative phosphorylation but decreased mitochondrial respiratory capacity in IL-1β treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86. - »Bioblast link«
- Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28. - »Bioblast link«
- Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286:H1633–41. - »Bioblast link«
- Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543:39-56. - »Bioblast link«
- Renner K, Amberger A, Konwalinka G, Kofler R, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23. - »Bioblast link«
- Gnaiger E, Kuznetsov AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30:252-8. - »Bioblast link«
- Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3. - »Bioblast link«
- Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128:277-97. - »Bioblast link«
- Gnaiger E, Méndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97:11080-5.»Bioblast link«
12 selected publications: up to 1999
- Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413:99-107. - »Bioblast link«
- Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol 201:1129-39. - »Bioblast link«
- Gnaiger E, Lassnig B, Kuznetsov AV, Margreiter R (1998) Mitochondrial respiration in the low oxygen environment of the cell. Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1365:249-54. - »Bioblast link«
- Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42. - »Bioblast link«
- Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61. - »Bioblast link«
- Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27:583-96. - »Bioblast link«
- Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109. - »Bioblast link«
- Von Stockar U, Gustafsson L, Larsson C, Marison I, Tissot P, Gnaiger E (1993) Thermodynamic considerations in constructing energy balances for cellular growth. Biochim Biophys Acta 1183:221-40. - »Bioblast link«
- Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol 265:R1014-19. - »Bioblast link«
- Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002. - »Bioblast link«
- Gnaiger E, Kemp RB (1990) Anaerobic metabolism in aerobic mammalian cells. Information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim Biophys Acta 1016:328-32. - »Bioblast link«
- Hand SC, Gnaiger E (1988) Anaerobic dormancy quantified in Artemia embryos: A calorimetric test of the control mechanism. Science 239:1425-7. - »Bioblast link«
Expeditions: The world as a laboratory
- Northern Greenland 2004
- Monte Rosa, Italy 2004
- Mt. Chacaltaya, Bolivia 2012
- Everest Base Camp, Nepal 2013
- Racing dogs at Iditarod, Alaska 2014
- Collaboration of Michael Davis and Katherine Williamson (Comparative Exercise Physiology Laboratory, Oklahoma State University) with Martin Buser (Happy Trails Kennel, Alaska), Robert Boushel (Vancouver, Canada), Benjamin F. Miller and Karyn Hamilton (Fort Collins, US), and Erich Gnaiger and Verena Laner (Innsbruck, Austria and Oroboros Instruments) - a Power O2k-Respirometer project with six Oroboros O2k.
- » Racing dogs Alaska, IOC84
- Racing dogs at Iditarod, Alaska 2014
- To the heart of the Amazon, Manaus 2015
- Can mitochondria from fish heart help understanding why human heart mitochondria work the way they do? - An O2k-Workshop and pilot project with the O2k-Network Lab in Manaus: BR Manaus Val AL
- To the heart of the Amazon, Manaus 2015
Websites
- Further information
- Houska Award 2012 - The project MitoCom Tyrol received the Houska Award 2012, Austria's most prestigeous privately funded award for research.
- Further information
- Member of Mitochondrial Global Network Centres
- Founder of the Company of Scientists
MitoFit
- DSL-Oroboros Research Laboratory
- Daniel Swarovski Research Laboratory (DSL)
- Department of Visceral, Transplant and Thoracic Surgery
- Medical University of Innsbruck, Austria
- MitoFit is a consortium of academic and industrial partners for integrative research in mitochondrial physiology and pathology. MitoFit (Universities of Innsbruck; Oroboros Instruments, WGT Elektronik, Austria) supports international mitochondrial networks, for exchange of expertise and standardization of diagnostic approaches, in a joint effort to helping mitochondrial patients and making a difference to society. The project MitoCom Tyrol (2011-2014) was a milestone in the establishment of MitoFit, supported by K-Regio to promote science, research and development within the area of Tyrol.
- Preservation, gain or loss of mitochondrial fitness plays an increasing role in therapeutic and preventive medicine, with exercise and caloric balance ranking among the most effective measures for the reduction of several age-related health risks and degenerative diseases. Evaluation of mitochondrial competence requires improved methods and concepts for the diagnosis of mitochondrial functions and mitochondrial injuries, and represents a current challenge for biomedical research and development. MitoFit is a gateway to better diagnose, support and treat patients in our modern, rapidly ageing society.