From Bioblast
Description
Complex IV or cytochrome c oxidase is the terminal oxidase of the mitochondrial ETS, reducing oxygen to water, with reduced cytochrome c as a substrate. CIV is frequently abbreviated as COX or CcO. It is the 'ferment' (Atmungsferment) of Otto Warburg, shown to be related to the cytochromes discovered by David Keilin.
Abbreviation: CIV
Reference: MiPNet06.06
HRR protocol: Complex IV assay
Ascorbate and TMPD
- Ascorbate (As; 2 mM) and TMPD (Tm; 0.5 mM) are added to mitochondrial preparations. It is important to add ascorbate before TMPD to avoid uncontrollable autoxidation. Ascorbate maintains TMPD in a reduced state. Electrons flow from TMPD to cytochrome c.
- Cytochrome c oxidase (CIV) in intact mitochondra has a biphasic kinetics for TMPD (Gnaiger_2002_Biochem_Soc_Trans). Due to the high K'm of the low-affinity phase, TMPD cannot be added at saturating concentrations, since then autoxidation of TMPD would be strikingly high. The actually chosen TMPD concentration, therefore, is a compromise. Inhibitor titrations with cyanide or azide of ETS pathway flux versus the single step of CIV reveal an apparent excess capacity of CIV. The optimum TMPD concentration, therefore, is adjusted to obtain a reaction velocity corresponding to the apparent excess capacity (Gnaiger_1998_J Exp Biol).
Correction for chemical O2 background
- Due to autooxidation of ascorbate and TMPD, a chemical correction has to be applied on flux. Autooxidation is higher in the presence than in the absence of cytochrome c, and is dependent on oxygen concentration. The oxygen dependence is linear above c. 50 µM O2, but biphasic (linear+hyperbolic) below 50 µM O2. If you maintain oxygen in the linear dependence above 50 µM, you can use the automatic instrumental background correction in DatLab to also take care of the chemical background correction (in the ‘Edit Experiment’ window the instrumental background parameters are replaced by the combined background parameters). Cyanide is OK except if you use pyruvate as a substrate. Pyruvate particularly at high oxygen levels reverses the inhibition by cyanide (see Cyanide).
References
- O2k-Protocol: MiPNet06.06 Chemical O2 background
- Publications
- Intact cells are inadequate for CIV measurement with As+Tm - use permeabilized cells: Renner_2002_Mol_Biol_Rep, Renner_2003_Biochim_Biophys_Acta
- Isolated mitochondria: Gnaiger_2002_Biochem_Soc_Trans
- Permabilized fibres: Kuznetsov_2004_Am_J_Physiol_Heart_Circ_Physiol, Lemieux_2011_Int_J_Biochem_Cell_Biol
- Publications
List of publications: Complex IV;cytochrome c oxidase
Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
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Garcia-Poyatos 2024 Dev Cell | 2024 | García-Poyatos C, Arora P, Calvo E, Marques IJ, Kirschke N, Galardi-Castilla M, Lembke C, Meer M, Fernández-Montes P, Ernst A, Haberthür D, Hlushchuk R, Vázquez J, Vermathen P, Enríquez JA, Mercader N (2024) Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization. Dev Cell [Epub ahead of print]. https://doi.org/10.1016/j.devcel.2024.04.012 | Zebrafish | Skeletal muscle | ||
Jiang 2024 Nat Metab | 2024 | Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3 | Mouse | Liver | Obesity Other | |
Koizumi 2023 Front Cardiovasc Med | 2023 | Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T (2023) Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats. Front Cardiovasc Med 10: 1005408. | Rat | Heart | Cardiovascular Diabetes | |
Fletcher 2023 Transl Res | 2023 | Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002 | Mouse | Skeletal muscle | Myopathy Obesity | |
Luptak 2023 Antioxidants (Basel) | 2023 | Ľupták M, Fišar Z, Hroudová J (2023) Different effects of SSRIs, Bupropion, and Trazodone on mitochondrial functions and monoamine oxidase isoform activity. Antioxidants (Basel) 12:1208. https://doi.org/10.3390/antiox12061208 | Pig | Nervous system | Neurodegenerative | |
Wikstroem 2023 Enzymes | 2023 | Wikström M, Pecorilla C, Sharma V (2023) The mitochondrial respiratory chain. Enzymes 54:15-36. https://doi.org/10.1016/bs.enz.2023.05.001 | ||||
Wikstroem 2023 Biochim Biophys Acta Bioenerg | 2023 | Wikström M, Gennis RB, Rich PR (2023) Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase. Biochim Biophys Acta Bioenerg 1864:148933. https://doi.org/10.1016/j.bbabio.2022.148933 | ||||
Saura 2022 Proc Natl Acad Sci U S A | 2022 | Saura P, Riepl D, Frey DM, Wikström M, Kaila VRI (2022) Electric fields control water-gated proton transfer in cytochrome c oxidase. Proc Natl Acad Sci U S A 119:e2207761119. https://doi.org/10.1073/pnas.2207761119 | ||||
LaMoia 2022 Proc Natl Acad Sci U S A | 2022 | LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, Gaspar RC, Zhang XM, Cline GW, Nakahara K, Woo S, Shimada A, Hüttemann M, Shulman GI (2022) Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis. Proc Natl Acad Sci U S A 119:e2122287119. https://doi.org/10.1073/pnas.2122287119 | ||||
Timon-Gomez 2022 Elife | 2022 | Timón-Gómez A, Scharr AL, Wong NY, Ni E, Roy A, Liu M, Chau J, Lampert JL, Hireed H, Kim NS, Jan M, Gupta AR, Day RW, Gardner JM, Wilson RJA, Barrientos A, Chang AJ (2022) Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors. https://doi.org/10.7554/elife.78915 | Hypoxia | |||
Vercellino 2022 Nat Rev Mol Cell Biol | 2022 | Vercellino I, Sazanov LA (2022) The assembly, regulation and function of the mitochondrial respiratory chain. Nat Rev Mol Cell Biol 23:141-161. doi: 10.1038/s41580-021-00415-0 | ||||
Terwilliger 2021 Vasc Med | 2021 | Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58. | Human | Skeletal muscle | Cardiovascular | |
Vidimce 2021 Front Pharmacol | 2021 | Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715. | Rat | Skeletal muscle Liver | ||
Ko 2021 Biomolecules | 2021 | Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR (2021) The phosphorylation status of Drp1-Ser637 by PKA in mitochondrial fission modulates mitophagy via PINK1/Parkin to exert multipolar spindles assembly during mitosis. Biomolecules 11:424. | Human | HeLa | ||
Burska 2021 Biochim Biophys Acta Mol Basis Dis | 2021 | Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147. | Human | Fibroblast | Myopathy | |
Sighel 2021 Cell Rep | 2021 | Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024. | Human | Nervous system Stem cells | Cancer | |
Chambers 2021 JCI Insight | 2021 | Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340. | Mouse | Heart | Cardiovascular | |
Peruzzotti-Jametti 2021 PLoS Biol | 2021 | Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166. | Mouse | Nervous system Stem cells | Neurodegenerative | |
Dubinin 2021 Membranes (Basel) | 2021 | Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352. | Rat | Liver | ||
Bastos Sant'Anna Silva 2021 Cancers (Basel) | 2021 | Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727 | Human | Genital | Cancer | |
Latina 2021 Acta Neuropathol Commun | 2021 | Latina V, Giacovazzo G, Cordella F, Balzamino BO, Micera A, Varano M, Marchetti C, Malerba F, Florio R, Ercole BB, La Regina F, Atlante A, Coccurello R, Di Angelantonio S, Calissano P, Amadoro G (2021) Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathol Commun 9:38. | Mouse | Nervous system | Alzheimer's | |
Vercellino 2021 Nature | 2021 | Vercellino I, Sazanov LA (2021) Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV. Nature 598:364-367. doi: 10.1038/s41586-021-03927-z | Mouse | |||
Bittel 2021 Diabetes | 2021 | Bittel DC, Bittel AJ, Varadhachary AS, Pietka T, Sinacore DR (2021) Deficits in the skeletal muscle transcriptome and mitochondrial coupling in progressive diabetes-induced CKD relate to functional decline. Diabetes 70:1130-44. https://doi.org/10.2337/db20-0688 | Human | Skeletal muscle | Diabetes Other | |
Brischigliaro 2021 Biochim Biophys Acta Bioenerg | 2021 | Brischigliaro M, Zeviani M (2021) Cytochrome c oxidase deficiency. Biochim Biophys Acta Bioenerg 1862:148335. doi: 10.1016/j.bbabio.2020.148335 | ||||
Brzezinski 2021 Chem Rev | 2021 | Brzezinski P, Moe A, Ädelroth P (2021) Structure and mechanism of respiratory III-IV supercomplexes in bioenergetic membranes. Chem Rev 121:9644-73. https://doi.org/10.1021/acs.chemrev.1c00140 | Saccharomyces cerevisiae Eubacteria | |||
Ferreira 2020 PLoS Genet | 2020 | Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604. | Mouse | Liver | Mitochondrial disease | Infectious |
Venediktova 2020 Mitochondrion | 2020 | Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion 52:190-96. | Rat | Liver | Other | |
Briones-Herrera 2020 Free Radic Biol Med | 2020 | Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70. | Rat | Kidney | ||
Hassan 2020 MitoFit Preprint Arch | 2020 | Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003 | Human | Mitochondrial disease | Autism | |
Miotto 2020 Am J Physiol Endocrinol Metab | 2020 | Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53. | Rat | Skeletal muscle | Diabetes | |
Ajime 2020 Nicotine Tob Res | 2020 | Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res 23:143-51. | Mouse | Skeletal muscle | ||
Huete-Ortega 2020 MitoFit Preprint Arch EA | 2020 | Huete-Ortega M, Di Marcello M, Iglesias-Gonzalez J, Gnaiger E (2020) High-resolution respirometry for chloroplast and mitochondrial bioenergetics in Chlamydomonas reinhardtii ― towards biotechnology exploitations. https://doi.org/10.26124/mitofit:ea20.algaeurope.0001 | Algae | |||
Monaco 2020 Am J Physiol Endocrinol Metab | 2020 | Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51. | Human | Skeletal muscle | Diabetes | |
Protasoni 2020 EMBO J | 2020 | Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817. | Human | Other cell lines | ||
Wei 2020 Hum Mutat | 2020 | Wei X, Du M, Li D, Wen S, Xie J, Li Y, Chen A, Zhang K, Xu P, Jia M, Wen C, Zhou H, Lyu J, Yang Y, Fang H (2020) Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. Hum Mutat 41:961-72. | Human | Lymphocyte | Mitochondrial disease | |
Kalpage 2020 Int J Biochem Cell Biol | 2020 | Kalpage HA, Wan J, Morse PT, Zurek MP, Turner AA, Khobeir A, Yazdi N, Hakim L, Liu J, Vaishnav A, Sanderson TH, Recanati MA, Grossman LI, Lee I, Edwards BFP, Hüttemann M (2020) Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis. Int J Biochem Cell Biol 121:105704. | Cell death | |||
Silva-Rodrigues 2020 Free Radic Biol Med | 2020 | Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806. | Rat | Nervous system | Oxidative stress;RONS | Diabetes |
Agil 2020 J Clin Med | 2020 | Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916. | Rat | Kidney | Diabetes Obesity | |
Hroudova 2020 Mol Neurobiol | 2020 | Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-in vitro study. Mol Neurobiol 58:1102-13. | Pig | Nervous system | ||
Bundgaard 2020 J Exp Biol | 2020 | Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410. | Amphibians | Heart | ||
Wikstroem 2020 Commun Biol | 2020 | Wikström M, Springett R (2020) Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain. Commun Biol 3:451. https://doi.org/10.1038/s42003-020-01192-w | ||||
Trefts 2019 Thesis | 2019 | Trefts E (2019) Integrin linked kinase is critical for hepatic cellular organization, metabolism, and glucoregulation. PhD Thesis 164. | Mouse | Liver | Other | |
Larsen 2019 Appl Physiol Nutr Metab | 2019 | Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64. | Human | Skeletal muscle | ||
Hafen 2019 J Appl Physiol (1985) | 2019 | Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57. https://doi.org/10.1152/japplphysiol.01098.2018 | Human | Skeletal muscle | Temperature | |
Chatfield 2019 JACC Basic Transl Sci | 2019 | Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. | Human | Heart | Cardiovascular | |
Lauridsen 2019 Mitochondrion | 2019 | Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion 47:47-53. | Human | Other cell lines | Cryopreservation | |
Stepanova 2019 Antioxid Redox Signal | 2019 | Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22. | Mouse | Nervous system | Ischemia-reperfusion | |
Munro 2019 Aging Cell | 2019 | Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916. | Mouse Other mammals | Heart Skeletal muscle | Oxidative stress;RONS | Aging;senescence |
Robinson 2019 Am J Physiol Cell Physiol | 2019 | Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347. | Mouse Rat | Skeletal muscle | ||
Chroeis 2019 Eur J Sport Sci | 2019 | Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45. | Human | Skeletal muscle | Aging;senescence | |
Braganza 2019 JCI Insight | 2019 | Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248. | Human | Skeletal muscle Blood cells Platelet | Aging;senescence | |
Di Marcello 2019 MitoFit Preprint Arch EA | 2019 | Di Marcello M, Iglesias-Gonzalez J, Meszaros A, Haider M, Gnaiger E, Huete-Ortega M (2019) Partitioning between cytochrome c oxidase and alternative oxidase studied by oxygen kinetics of dark respiration in Chlamydomonas reinhardtii: a microalgae model organism. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0005.v3 | Plants | |||
Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol | 2019 | Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) In vitro effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23. | Pig | Nervous system | ||
Chang 2019 Br J Anaesth | 2019 | Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21. | Human | Skeletal muscle | Temperature | |
Lemieux 2019 bioRxiv | 2019 | Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 . | Mouse | Blood cells | Cell death | Cancer |
Doig 2019 bioRxiv | 2019 | Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 . | Mouse | Skeletal muscle | ||
Zverova 2019 Neuropsychiatr Dis Treat | 2019 | Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40. | Human | Platelet Blood cells | Other | |
Desmoulins 2019 Mol Metab | 2019 | Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77. | Rat | Nervous system | ||
Trefts 2019 Am J Physiol Endocrinol Metab | 2019 | Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH (2019) Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and the postabsorptive response of mice in an age-dependent manner. Am J Physiol Endocrinol Metab 316:1118-35. | Mouse | Liver | ||
Vaka 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447. | Human Rat | Endothelial;epithelial;mesothelial cell Genital | Ischemia-reperfusion Oxidative stress;RONS | |
Cesnekova 2019 Thesis | 2019 | Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133. | Human | HEK | ||
Alvarez 2019 Chem Biol Interact | 2019 | Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71. | Human | Liver | Cancer | |
Laouafa 2019 Acta Physiol (Oxf) | 2019 | Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255. | Rat | Nervous system | Hypoxia | |
Zhao 2019 Basic Res Cardiol | 2019 | Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12. | Rat | Heart Fibroblast | Ischemia-reperfusion | |
Spinazzi 2019 Proc Natl Acad Sci U S A | 2019 | Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86. 10.1073/pnas.1811938116 | Mouse | Nervous system | Neurodegenerative | |
Petrick 2019 J Physiol | 2019 | Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97. | Human | Skeletal muscle | Oxidative stress;RONS | |
Pignanelli 2019 Thesis | 2019 | Pignanelli CJ (2019) Muscular adaptations to low-load resistance training to repetition failure with and without blood flow restriction. Master's Thesis 80. | Human | Skeletal muscle | ||
Friederich 2019 Mol Genet Metab | 2019 | Friederich MW, Perez FA, Knight KM, Van Hove RA, Yang SP, Saneto RP, Van Hove JLK (2019) Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement. Mol Genet Metab 129:236-42. | Human | Fibroblast | Mitochondrial disease | |
Du 2019 J Virol | 2019 | Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19. | Horse | Blood cells Other cell lines | Cell death | Infectious |
Thome 2019 Am J Physiol Cell Physiol | 2019 | Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13. | Mouse | Skeletal muscle | Other | |
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Asiri 2017 Thesis | 2017 | Asiri A (2017) Effects of asiatic acid on neurite outgrowth in Neuro-2a cells. Master's Thesis p42. | Mouse | Nervous system | Cancer | |
Scheede-Bergdahl 2017 Can J Physiol Pharmacol | 2017 | Scheede-Bergdahl C, Bergdahl A (2017) Adaptation of mitochondrial expression and ATP production in dedifferentiating vascular smooth muscle cells. Can J Physiol Pharmacol 95:1473-9. | Mouse | Endothelial;epithelial;mesothelial cell | Cardiovascular | |
Rowley 2017 Thesis | 2017 | Rowley TJ (2017) The effect of cocoa flavanols on β-cell mass and function. Master's Thesis p131. | Rat | Islet cell;pancreas;thymus | Diabetes Obesity | |
Singhal 2017 Mol Biol Cell | 2017 | Singhal RK, Kruse C, Heidler J, Strecker V, Zwicker K, Düsterwald L, Westermann B, Herrmann JM, Wittig I, Rapaport D (2017) Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex. Mol Biol Cell 28:2609-22. | Saccharomyces cerevisiae | |||
Schmidt 2017 J Vasc Surg | 2017 | Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514. | Mouse | Skeletal muscle | Hypoxia | Myopathy Other |
Zhou 2017 Biochim Biophys Acta | 2017 | Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5. | Human | Fibroblast | Parkinson's | |
McFarlane 2017 Am J Physiol Regul Integr Comp Physiol | 2017 | McFarlane SV, Mathers KE, Staples JF (2017) Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 312:R434-42. | Other mammals | Fat | Temperature | |
Lopez 2017 Sci Rep | 2017 | Lopez Sanchez MIG, Waugh HS, Tsatsanis A, Wong BX, Crowston JG, Duce JA, Trounce IA (2017) Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta. Sci Rep 7:9835. | Human | Alzheimer's Cancer | ||
Welker 2017 Thesis | 2017 | Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26. | Mouse | Cancer | ||
Blecha 2017 Free Radic Biol Med | 2017 | Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66. | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS | Cancer | |
Rowley 2017 J Nutr Biochem | 2017 | Rowley TJ, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, Goodrich KM, Ye L, O'Keefe SF, Neilson AP, Tessem JS (2017) Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. J Nutr Biochem 49:30-41. | Rat | Islet cell;pancreas;thymus | Diabetes | |
Ferens 2017 Biochem Cell Biol | 2017 | Ferens FG, Spicer V, Krokhin OV, Motnenko A, Summers WA, Court DA (2017) A deletion variant partially complements a porin-less strain of Neurospora crassa. Biochem Cell Biol 95:318-27. | Fungi | |||
Mathers 2017 J Comp Physiol B | 2017 | Mathers KE, McFarlane SV, Zhao L, Staples JF (2017) Regulation of mitochondrial metabolism during hibernation by reversible suppression of electron transport system enzymes. J Comp Physiol B 187:227-34. | Other mammals | Liver | Temperature | |
Zhang 2017 J Biol Chem | 2017 | Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES (2017) Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem 292:10239-49. | Human | Liver HEK | ||
Newsom 2017 Am J Physiol Endocrinol Metab | 2017 | Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62. | Mouse | Skeletal muscle | Diabetes Obesity | |
Schatton 2017 J Cell Biol | 2017 | Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI (2017) CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol 216:675-93. | Mouse | Liver | ||
Koit 2017 Oxid Med Cell Longev | 2017 | Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640. | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
Greggio 2017 Cell Metab | 2017 | Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Alonso SC, Ofori E, Auwerx J, Cantó C, Amati F (2017) Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metab 25:301-11. | Human | Skeletal muscle | ||
Mahalingam 2017 J Physiol | 2017 | Mahalingam S, McClelland GB, Scott GR (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J Physiol 595:4785-801. | Mouse | Skeletal muscle | Hypoxia | |
Gusdon 2017 Exp Gerontol | 2017 | Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13. | Mouse | Nervous system | Oxidative stress;RONS | Aging;senescence |
Bohanon 2017 Shock | 2017 | Bohanon FJ, Lopez ON, Herndon DN, Wang X, Bhattarai N, Ayadi AE, Prasai A, Jay JW, Rojas-Khalil Y, Toliver-Kinsky TE, Finnerty CC, Radhakrishnan RS, Porter C (2017) Burn trauma acutely increases the respiratory capacity and function of liver mitochondria. Shock 49:466-73. | Mouse | Liver | ||
Nogueira 2017 Free Radic Biol Med | 2017 | Nogueira NP, Saraiva FMS, Oliveira MP, Mendonca APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Lopes Torres EJ, Oliveira MF, Paes MC (2017) Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radic Biol Med 108:183-91. | Protists | Oxidative stress;RONS | ||
Gruenig 2017 Toxicol In Vitro | 2017 | Grünig D, Felser A, Bouitbir J, Krähenbühl S (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicol In Vitro 42:337-47. | Human Mouse | Liver Other cell lines | ||
Tegelberg 2017 Orphanet J Rare Dis | 2017 | Tegelberg S, Tomašić N, Kallijärvi J, Purhonen J, Elmér E, Lindberg E, Nord DG, Soller M, Lesko N, Wedell A, Bruhn H, Freyer C, Stranneheim H, Wibom R, Nennesmo I, Wredenberg A, Eklund EA, Fellman V (2017) Respiratory chain complex III deficiency due to mutated BCS1L: a novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model. Orphanet J Rare Dis 12:73. | Human Mouse | Blood cells Platelet | Other | |
Derungs 2017 Mol Psychiatry | 2017 | Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, Späni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L (2017) Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. Mol Psychiatry 22:605-14. | Mouse | Nervous system | Aging;senescence Alzheimer's | |
Linden 2016 Am J Physiol Gastrointest Liver Physiol | 2017 | Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS (2017) A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol 311:G387-95. | Rat | Liver | Obesity | |
Van den Berg 2017 Am J Respir Crit Care Med | 2017 | van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC (2017) Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically ill. Am J Respir Crit Care Med 196:1544-58. | Human | Skeletal muscle | Other | |
Neckar 2017 Clin Sci (Lond) | 2017 | Neckar J, Svatonova A, Weissova R, Drahota Z, Zajickova P, Brabcova I, Kolar D, Alanova P, Vasinova J, Silhavy J, Hlavackova M, Tauchmannova K, Milerova M, Ostadal B, Cervenka L, Zurmanova J, Kalous M, Novakova O, Novotny J, Pravenec M, Kolar F (2017) Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats. Clin Sci (Lond) 131:865-81. | Rat | Heart | Permeability transition Hypoxia | Cardiovascular |
Letts 2017 Nat Struct Mol Biol | 2017 | Letts JA, Sazanov LA (2017) Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain. Nat Struct Mol Biol 24:800-8. https://doi.org/10.1038/nsmb.3460 | ||||
Liang 2017 Proc Natl Acad Sci U S A | 2017 | Liang R, Swanson JMJ, Wikström M, Voth GA (2017) Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase. Proc Natl Acad Sci U S A 114:5924-9. https://doi.org/10.1073/pnas.1703654114 | ||||
Siletsky 2017 Biochim Biophys Acta Bioenerg | 2017 | Siletsky SA, Belevich I, Belevich NP, Soulimane T, Wikström M (2017) Time-resolved generation of membrane potential by ba3 cytochrome c oxidase from Thermus thermophilus coupled to single electron injection into the O and OH states. Biochim Biophys Acta Bioenerg 1858:915-26. https://doi.org/10.1016/j.bbabio.2017.08.007 | ||||
Haegler 2017 PLOS ONE | 2017 | Haegler P, Grünig D, Berger B, Terracciano L, Krähenbühl S, Bouitbir J (2017) Hepatic effects of pharmacological doses of hydroxy-cobalamin[c-lactam] in mice. PLOS ONE 12:e0171026. | Mouse | Liver | ||
Friederich 2017 Hum Mol Genet | 2017 | Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16. | Human | Fibroblast | Myopathy | |
Lin 2017 Dis Model Mech | 2017 | Lin H, Magrane J, Rattelle A, Stepanova A, Galkin A, Clark EM, Dong YN, Halawani SM, Lynch DR (2017) Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Dis Model Mech 10(11):1343-52. | Mouse | Nervous system | Inherited | |
Mueller 2017 Orphanet J Rare Dis | 2017 | Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184. | Human | Skeletal muscle | Neurodegenerative | |
Buso 2017 Thesis | 2017 | Buso A (2017) Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies. PhD Thesis p110. | Mouse | Skeletal muscle | Aging;senescence | |
Profilo 2017 Biochim Biophys Acta | 2017 | Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta 1863:1422-35. | Mouse | Nervous system Other cell lines Neuroblastoma | ||
Ma 2017 Int J Cancer | 2017 | Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. Int J Cancer 142:1786-96. | Human | Cancer | ||
Comelli 2017 J Bioenerg Biomembr | 2017 | Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52. | Human | Nervous system | Cancer | |
Lores-Arnaiz 2017 J Neurochem | 2017 | Lores-Arnaiz S, Karadayian AG, Gutnisky A, Rodríguez de Lores Arnaiz G (2017) The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms. J Neurochem 143:684-96. | Rat | Nervous system | ||
Dent 2017 Mol Metab | 2017 | Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84. | Mouse | Skeletal muscle | ||
Hals 2017 Physiol Rep | 2017 | Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V (2017) Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates. Physiol Rep 5. pii: e13447. | Human Mouse | Islet cell;pancreas;thymus | Hypoxia | |
Volani 2017 Metallomics | 2017 | Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G (2017) Dietary iron loading negatively affects liver mitochondrial function. Metallomics 9:1634-44. | Mouse | Liver | ||
Xu 2017 J Hum Genet | 2017 | Xu B, Li X, Du M, Zhou C, Fang H, Lyu J, Yang Y (2017) Novel mutation of ND4 gene identified by targeted next-generation sequencing in patient with Leigh syndrome. J Hum Genet 62:291-7. | Human | Blood cells Platelet | Neurodegenerative | |
JanssenDuijghuijsen 2017 Front Physiol | 2017 | JanssenDuijghuijsen LM, Grefte S, de Boer VCJ, Zeper L, van Dartel DAM, van der Stelt I, Bekkenkamp-Grovenstein M, van Norren K, Wichers HJ, Keijer J (2017) Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes Claudin 7. Front Physiol 8:794. | Human | Endothelial;epithelial;mesothelial cell Other cell lines | ||
Bombaca 2017 Free Radic Biol Med | 2017 | Bombaça ACS, Dias FA, Ennes-Vidal V, Garcia-Gomes ADS, Sorgine MHF, d'Avila-Levy CM, Menna-Barreto RFS (2017) Hydrogen peroxide resistance in Strigomonas culicis: Effects on mitochondrial functionality and Aedes aegypti interaction. Free Radic Biol Med 113:255-66. | Protists | |||
Ruiz 2017 Brain Pathol | 2017 | Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30. | Human Mouse | Nervous system Fibroblast | Oxidative stress;RONS | Inherited Neurodegenerative |
Fisar 2016 Curr Alzheimer Res | 2016 | Fišar Z, Hroudová J, Hansíková H, Spáčilová J, Lelková P, Wenchich L, Jirák R, Zvěřová M, Zeman J, Martásek P, Raboch J (2016) Mitochondrial respiration in the platelets of patients with Alzheimer's disease. Curr Alzheimer Res 13:930-41. | Human | Blood cells Platelet | Alzheimer's | |
Spendiff 2016 J Physiol | 2016 | Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT (2016) Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-79. | Human Mouse | Skeletal muscle | Permeability transition | Aging;senescence Myopathy |
Lim 2016 FASEB J | 2016 | Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48. | Human | Other cell lines | Cancer | |
Chang 2016 Transl Res | 2016 | Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH, Kuo SJ, Liu CS (2016) Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res 170:40-56. | Rat | Nervous system Other cell lines | Parkinson's | |
Bareth 2016 Mol Biol Cell | 2016 | Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick DU, Helbig C, Urlaub Z, Ott M, Rehling P, Dennerlein S (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27:1570-80. | Saccharomyces cerevisiae | |||
Scott 2016 Thesis | 2016 | Scott KY (2016) Evaluation of cardiac mitochondrial function in the fructose-fed rat. Master's Thesis p98. | Rat | Heart | Diabetes | |
Lund 2016 J Physiol | 2016 | Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8. | Human | Liver | Diabetes Obesity | |
Distefano 2016 J Gerontol A Biol Sci Med Sci | 2016 | Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42. | Human | Skeletal muscle | Aging;senescence | |
Bratic 2016 PLoS Genet | 2016 | Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028. | Drosophila | |||
Leucci 2016 Nature | 2016 | Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22. | Human | Endothelial;epithelial;mesothelial cell Other cell lines | Cancer | |
Letts 2016 Nature | 2016 | Letts JA, Fiedorczuk K, Sazanov LA (2016) The architecture of respiratory supercomplexes. Nature 537:644-8. https://doi.org/10.1038/nature19774 | Bovines | Oxidative stress;RONS | ||
Liang 2016 Proc Natl Acad Sci U S A | 2016 | Liang R, Swanson JM, Peng Y, Wikström M, Voth GA (2016) Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidase. Proc Natl Acad Sci U S A 113:7420-5. https://doi.org/10.1073/pnas.1601982113 | ||||
Iglesias-Gonzalez 2016 Mol Neurobiol | 2016 | Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70. | Rat | Nervous system | Alzheimer's Neurodegenerative Parkinson's | |
Amaral 2016 Biochim Biophys Acta | 2016 | Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KD, Ribeiro RT, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency. Biochim Biophys Acta 1857:1363-72. | Rat | Nervous system Liver | Permeability transition Oxidative stress;RONS | |
Bombicino 2016 Arch Biochem Biophys | 2016 | Bombicino SS, Iglesias DE, Zaobornyj T, Boveris A, Valdez LB (2016) Mitochondrial nitric oxide production supported by reverse electron transfer. Arch Biochem Biophys 607:8-19. | Rat | Heart | ||
Rohlenova 2016 Antioxid Redox Signal | 2016 | Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103. | Human Mouse | Liver Genital Other cell lines | Oxidative stress;RONS | Cancer |
Singh 2016 Mol Neurobiol | 2016 | Singh N, Hroudová J, Fišar Z (2016) In vitro effects of cognitives and nootropics on mitochondrial respiration and monoamine oxidase activity. Mol Neurobiol 54:5894-904. | Pig | Nervous system | Alzheimer's | |
Richman 2016 Nat Commun | 2016 | Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884. | Mouse | Heart Liver | Mitochondrial disease | |
Reijne 2016 PLOS ONE | 2016 | Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud DJ, Bakker BM, van Dijk G (2016) Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLOS ONE 11:e0149419. | Mouse | Skeletal muscle Liver | Aging;senescence | |
Lores-Arnaiz 2016 Neurochem Res | 2016 | Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63. | Mouse | Nervous system | Aging;senescence | |
Castellano-Gonzalez 2016 Oncotarget | 2016 | Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40 | Human | Nervous system | ||
Siewiera 2016 Life Sci | 2016 | Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304. | Rat | Blood cells Platelet | Diabetes | |
Strifler 2016 PLOS ONE | 2016 | Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363. | Rat | Liver | Ischemia-reperfusion | |
Li 2016 Neurochem Int | 2016 | Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats. Neurochem Int 92:35-42. | Rat | Nervous system | Neurodegenerative | |
Volt 2016 J Pineal Res | 2016 | Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205. | Mouse | Heart | Aging;senescence Sepsis | |
Schinagl 2016 PLoS One | 2016 | Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878. | Fungi | |||
Cacabelos 2016 Acta Neuropathol Commun | 2016 | Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3. | Mouse | Nervous system Other cell lines | Neurodegenerative | |
Doerrier 2016 Mitochondrion | 2016 | Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63. | Mouse | Heart | Sepsis | |
Bernardo 2015 J Nutr Biochem | 2016 | Bernardo AF, Cortez E, Neves FA, Vieira AKG, Soares V, Rodrigues-Cunha AC, Andrade DC, Thole AA, Gabriel-Costa D, Brum PC, Moura AS, Garcia-Souza EP (2015) Overnutrition during lactation leads to impairment in insulin signaling, upregulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. J Nutr Biochem 29:124-32. | Mouse | Heart | Diabetes Obesity | |
Schiffer 2016 Am J Physiol Cell Physiol | 2016 | Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61. | Human | Skeletal muscle HEK | Oxidative stress;RONS Hypoxia | |
Safiedeen 2016 Antioxid Redox Signal | 2016 | Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC (2016) Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction. Antioxid Redox Signal 26:15-27. | Human | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS | Diabetes Obesity Other |
Most 2016 Am J Clin Nutr | 2016 | Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27. | Human | Skeletal muscle | Diabetes Obesity | |
Hartmannova 2016 Hum Mol Genet | 2016 | Hartmannová H, Piherová L, Tauchmannová K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, Hodaňová K, Stránecký V, Přistoupilová A, Barešová V, Jedličková I, Živná M, Sovová J, Hůlková H, Robins V, Vrbacký M, Pecina P, Kaplanová V, Houštěk J, Mráček T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79. | Human | Fibroblast | Inherited | |
Milerova 2016 Mol Cell Biochem | 2016 | Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B (2016) Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem 412:147-54. | Rat | Heart | Ischemia-reperfusion | |
Thomas 2016 Neurodegeneration Therapeutics | 2016 | Thomas RR, Keeney PM, Berr SB, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Brohawn DG, Bennett JP (2016) Recombinant human TFAM stimulates rat brain, rat cervical spinal cord and human neural stem cell mitochondrial bioenergetics. Neurodegeneration Therapeutics p41. | Rat | Nervous system | Mitochondrial disease | |
Sobotka 2016 J Bioenerg Biomembr | 2016 | Sobotka O, Endlicher R, Drahota Z, Kučera O, Rychtrmoc D, Raad M, Hakeem K, Červinková Z (2016) Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes. J Bioenerg Biomembr 48:363-73. | Mouse Rat | Liver | Cell death Oxidative stress;RONS | |
Oliveira 2016 PLOS ONE | 2016 | Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429. | Other invertebrates | Oxidative stress;RONS | ||
Gomez 2016 Thesis | 2016 | Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102. | Reptiles | Heart Nervous system | Oxidative stress;RONS | |
Hagl 2016 Neuromolecular Med | 2016 | Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63. | Mouse | Nervous system | Aging;senescence Alzheimer's Neurodegenerative | |
Miotto 2016 Biochem J | 2016 | Miotto PM, Holloway GP (2016) In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport. Biochem J 473:2831-43. | Mouse | Skeletal muscle | ||
Sharma 2016 Biochim Biophys Acta | 2016 | Sharma V, Wikström M (2016) The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidase. Biochim Biophys Acta 1857:1111-5. https://doi.org/10.1016/j.bbabio.2016.02.008 | ||||
Rackham 2016 Cell Rep | 2016 | Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90. | Mouse | Heart | ||
McFarlane 2016 Thesis | 2016 | McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74. | Other mammals | Fat | Temperature | |
Davuluri 2016 J Physiol | 2016 | Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60. | Mouse | Skeletal muscle Other cell lines | Oxidative stress;RONS | |
Amigo 2016 Aging Cell | 2016 | Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81. | Mouse | Nervous system | ||
Khattar 2016 J Neurosci Methods | 2016 | Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM (2016) Isolation of functionally active and highly purified neuronal mitochondria from human cortex. J Neurosci Methods 263:1-6. | Human Mouse | Nervous system | ||
Melenovsky 2016 Eur J Heart Fail | 2016 | Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H, Pluhacek T, Spatenka J, Kovalcikova J, Drahota Z, Kautzner J, Pirk J, Houstek J (2016) Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail 19:522-30. | Human | Heart | Cardiovascular | |
Wang 2016 J Biol Chem | 2016 | Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Stolz DB, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV (2016) Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in Hepatoblastoma. J Biol Chem 291:26241-51. | Mouse | Liver | Cancer | |
Bastian 2016 Cancer Lett | 2016 | Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett pii: S0304-3835(16)30745-5. | Mouse | Cell death | Cancer | |
Szczepanowska 2016 EMBO J | 2016 | Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35:2566-83. | Mouse | Heart | ||
Gerber 2016 J Med Genet | 2016 | Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | ||
Frey 2016 Biochim Biophys Acta | 2016 | Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91. | Human | Nervous system | Other | |
Wuest 2016 Cardiovasc Res | 2016 | Wüst RC, de Vries HJ, Wintjes LT, Rodenburg RJ, Niessen HW, Stienen GJ (2016) Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure. Cardiovasc Res 111:362-72. | Rat | Heart | Cardiovascular | |
Levchenko 2016 Biochim Biophys Acta | 2016 | Levchenko M, Wuttke JM, Römpler K, Schmidt B, Neifer K, Juris L, Wissel M, Rehling P, Deckers M (2016) Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. Biochim Biophys Acta 1863:1624-32. | Saccharomyces cerevisiae | |||
Van Hoose 2016 J Nutr Biochem | 2016 | Van Hoose PM, Kelm NQ, Piell KM, Cole MP (2016) Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia. J Nutr Biochem 34:8-16. | Mouse | Heart | Ischemia-reperfusion | Cardiovascular |
Stepanova 2016 Biochim Biophys Acta | 2016 | Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A (2016) Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart. Biochim Biophys Acta 1857:1561-8. | Mouse | Heart Nervous system | ||
Ryan 2016 Diabetes | 2016 | Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM (2016) Targeted expression of catalase to mitochondria protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-68. | Mouse | Skeletal muscle | Ischemia-reperfusion | Diabetes |
Saben 2016 Cell Rep | 2016 | Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8. | Mouse | Skeletal muscle | Obesity | |
Davoudi 2016 PLOS ONE | 2016 | Davoudi M, Kotarsky H, Hansson E, Kallijärvi J, Fellman V (2016) COX7A2L/SCAFI and pre-complex III modify respiratory chain supercomplex formation in different mouse strains with a Bcs1l mutation. PLOS ONE 11:e0168774. | Mouse | Liver | Other | |
Wolter 2016 J Thromb Haemost | 2016 | Wolter J, Schild L, Bock F, Hellwig A, Gadi I, Al-Dabet MM, Ranjan S, Rönicke R, Nawroth PP, Petersen KU, Mawrin C, Shahzad K, Isermann B (2016) Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system. J Thromb Haemost 14:2212-26. | Mouse | Nervous system | Neurodegenerative | |
Van Zutphen 2016 J Hepatol | 2016 | van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJA, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208. | Rat | Liver | ||
Bal 2016 J Biol Chem | 2016 | Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M (2016) Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. J Biol Chem 291:17247-57. | Mouse | Skeletal muscle | Temperature | |
MiPNet06.06 Chemical O2 background | 2015-04-27 | Oxygraph assay of cytochrome c oxidase activity: chemical background correction. | ||||
Beauchamp 2015 Biosci Rep | 2015 | Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep 35. pii:e00200. | Mouse | Heart Liver | Cardiovascular Diabetes Obesity | |
Hanssen 2015 Nat Med | 2015 | Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5. | Human | Skeletal muscle | Temperature | Diabetes |
Senyilmaz 2015 Nature | 2015 | Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA (2015) Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature 525:124-8. | Drosophila | Parkinson's | ||
Lantier 2015 Diabetes | 2015 | Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH (2015) SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high fat fed mice. Diabetes 64:3081-92. | Mouse | Skeletal muscle | Diabetes | |
Ramos-Filho 2015 PLoS One | 2015 | Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766. | Rat | Skeletal muscle | ||
Harris 2015 Diabetes | 2015 | Harris LA, Skinner JR, Shew TM, Pietka TA, Abumrad NA, Wolins NE (2015) Perilipin 5-driven lipid droplet accumulation in skeletal muscle stimulates the expression of fibroblast growth factor 21. Diabetes 64:2757-68. | Mouse | Skeletal muscle | ||
Blatzer 2015 Antioxid Redox Signal | 2015 | Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D (2015) Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal 23:1424-38. https://doi.org/10.1089/ars.2014.6220 | Fungi | Oxidative stress;RONS | ||
Mourier 2015 J Cell Biol | 2015 | Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42. | Mouse | Heart Fibroblast | ||
Agil 2015 J Pineal Res | 2015 | Agil A, El-Hammadi M, Jiménez-Aranda A, Tassi M, Abdo W, Fernández-Vázquez G, Reiter RJ (2015) Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats. J Pineal Res 59:70-9. | Rat | Liver | Diabetes Obesity | |
Flatters 2015 Prog Mol Biol Transl Sci | 2015 | Flatters SJ (2015) The contribution of mitochondria to sensory processing and pain. Prog Mol Biol Transl Sci 131:119-46. | Rat | Nervous system | Diabetes Other | |
Soares 2015 PLoS One | 2015 | Soares JB, Gaviraghi A, Oliveira MF (2015) Mitochondrial physiology in the major arbovirus vector Aedes aegypti: substrate preferences and sexual differences define respiratory capacity and superoxide production. PLoS One 10:e0120600. | Hexapods | Skeletal muscle | Oxidative stress;RONS | |
Paglialunga 2015 Diabetologia | 2015 | Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80. | Mouse | Fat | Oxidative stress;RONS | Diabetes |
Luevano-Martinez 2015 Biochim Biophys Acta | 2015 | Luévano-Martínez LA, Forni MF, Dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2015) Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. Biochim Biophys Acta 1847:587-98. | Saccharomyces cerevisiae Fungi | Temperature | ||
Ludzki 2015 Diabetes | 2015 | Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle insulin signaling. Diabetes 64:2769-79. | Human Mouse | Skeletal muscle | Diabetes | |
Van Rahden 2015 Am J Hum Genet | 2015 | van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K (2015) Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet 96:640-50. | Human | HeLa | Cell death | Other |
Richman 2015 PLoS Genet | 2015 | Richman TR, Ermer JA, Davies SM, Perks KL, Viola HM, Shearwood AM, Hool LC, Rackham O, Filipovska A (2015) Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet 11:e1005089. | Mouse | Heart Liver | Mitochondrial disease | Aging;senescence Cardiovascular Other |
Caito 2015 Antioxid Redox Signal | 2015 | Caito SW, Aschner M (2015) Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal 23:578-95. | Human Mouse Rat Bovines Drosophila Fishes Hexapods | Heart Nervous system Liver Kidney Lung;gill Endothelial;epithelial;mesothelial cell | Cell death Ischemia-reperfusion Oxidative stress;RONS | COPD |
Lim 2015 Am J Cancer Res | 2015 | Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701. | Human | Kidney Other cell lines HEK HeLa Fibroblast | Cancer | |
Vincent 2015 Front Physiol | 2015 | Vincent G, Lamon S, Gant N, Vincent PJ, MacDonald JR, Markworth JF, Edge JA, Hickey AJ (2015) Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol 6:51. | Human | Skeletal muscle | ||
Schrauwen-Hinderling 2015 Antioxid Redox Signal | 2015 | Schrauwen-Hinderling VB, Kooi ME, Schrauwen P (2015) Mitochondrial function and diabetes; consequences for skeletal and cardiac muscle metabolism. Antioxid Redox Signal 24:39-51. | Human | Heart Skeletal muscle | Diabetes Other | |
Ydfors 2015 J Physiol | 2015 | Ydfors M, Hughes MC, Laham R, Schlattner U, Norrbom J, Perry CG (2015) Modelling in vivo creatine/phosphocreatine in vitro reveal divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise. J Physiol 594:3127-40. | Human | Skeletal muscle | ||
Sharma 2015 Proc Natl Acad Sci U S A | 2015 | Sharma V, Enkavi G, Vattulainen I, Róg T, Wikström M (2015) Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase. Proc Natl Acad Sci U S A 112:2040-5. https://doi.org/10.1073/pnas.1409543112 | ||||
Teh 2015 Oncogene | 2015 | Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M (2015) Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene 34:3296-304. | Human | Other cell lines | Cancer | |
Van Hoose 2015 Thesis | 2015 | Van Hoose P (2015) Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury. Dissertations p128. | Mouse | Heart | Ischemia-reperfusion | Cardiovascular |
Dungel 2015 Free Radic Biol Med | 2015 | Dungel P, Perlinger M, Weidinger A, Redl H, Kozlov AV (2015) The cytoprotective effect of nitrite is based on the formation of dinitrosyl iron complexes. Free Radic Biol Med 89:300-10. | Rat | Liver | Ischemia-reperfusion Oxidative stress;RONS | |
Kang 2015 Int J Clin Exp Med | 2015 | Kang M, Zhao L, Ren M, Deng M, Li C (2015) Reduced metallothionein expression induced by Zinc deficiency results in apoptosis in hepatic stellate cell line LX-2. Int J Clin Exp Med 8:20603-9. | Human | Liver Other cell lines | Cell death | |
Jiroutkova 2015 Crit Care | 2015 | Jiroutková K, Krajčová A, Ziak J, Fric M, Waldauf P, Džupa V, Gojda J, Němcova-Fürstová V, Kovář J, Elkalaf M, Trnka J, Duška F (2015) Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness. Crit Care 19:448. | Human | Skeletal muscle | Other | |
Patil 2015 J Nutr Biochem | 2015 | Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47. | Mouse | Skeletal muscle Liver Fat | ||
Blanchet 2015 Sci Rep | 2015 | Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Mitochondrial disease | |
Rodrigues 2016 Biochem J | 2015 | Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. https://doi.org/10.1042/BJ20150645 | Mouse | Endothelial;epithelial;mesothelial cell Other cell lines | Cancer | |
Czerniczyniec 2015 J Bioenerg Biomembr | 2015 | Czerniczyniec A, Lanza EM, Karadayian AG, Bustamante J, Lores-Arnaiz S (2015) Impairment of striatal mitochondrial function by acute paraquat poisoning. J Bioenerg Biomembr 47:395-408. | Rat | Nervous system | ||
Angebault 2015 Am J Hum Genet | 2015 | Angebault C, Guichet PO, Talmat-Amar Y, Charif M, Gerber S, Fares-Taie L, Gueguen N, Halloy F, Moore D, Amati-Bonneau P, Manes G, Hebrard M, Bocquet B, Quiles M, Piro-Mégy C, Teigell M, Delettre C, Rossel M, Meunier I, Preising M, Lorenz B, Carelli V, Chinnery PF, Yu-Wai-Man P, Kaplan J, Roubertie A, Barakat A, Bonneau D, Reynier P, Rozet JM, Bomont P, Hamel CP, Lenaers G (2015) Recessive mutations in RTN4IP1 cause isolated and syndromic optic neuropathies. Am J Hum Genet 97:754-60. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Other | |
Kishita 2015 Am J Hum Genet | 2015 | Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A (2015) Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97:761-8. | Human | Skeletal muscle Fibroblast | Inherited Other | |
Kruse 2015 Aging Cell | 2015 | Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ (2015) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15:89-99. | Mouse | Skeletal muscle | Oxidative stress;RONS | Aging;senescence |
Whitfield 2015 J Physiol | 2015 | Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, Spriet LL, Holloway GP (2015) Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol 594:421-35. | Human | Skeletal muscle | Oxidative stress;RONS | |
Llobet 2015 Dis Model Mech | 2015 | Llobet L, Toivonen JM, Montoya J, Ruiz-Pesini E, López-Gallardo E (2015) OXPHOS xenobiotics alter adipogenic differentiation at concentrations found in human blood. Dis Model Mech 8:1441-55. | Human | Fat Stem cells | ||
Martinez 2015 Thesis | 2015 | Martínez Gasca B (2015) Generacion de modelos celulares para el estudio del efecto fenotipico de la variacion genetica en el mtDNA. Thesis 1-35. | Human | Liver Other cell lines | ||
Ikaga 2015 Biochem Biophys Rep | 2015 | Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95. | Mouse | Fat Other cell lines | ||
Kelly 2014 J Appl Physiol | 2014 | Kelly NA, Ford MP, Standaert DG, Watts RL, Bickel CS, Moellering DR, Tuggle SC, Williams JY, Lieb L, Windham ST, Bamman MM (2014) Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's disease. J Appl Physiol 116:582-92. | Human | Skeletal muscle | Neurodegenerative Parkinson's | |
Van Bergen 2014 Mitochondrion | 2014 | Van Bergen NJ, Blake RE, Crowston JG, Trounce IA (2014) Oxidative phosphorylation measurement in cell lines and tissues. Mitochondrion 15:24-33. | Human Mouse | Nervous system Blood cells | ||
De Lucas 2014 J Sports Sci | 2014 | De Lucas DR, Caputo F, Mendes de Souza K, Sigwalt AR, Ghisoni K, Lock Silveira PC, Remor AP, da Luz Scheffer D, Antonacci Guglielmo LG, Latini A (2014) Increased platelet oxidative metabolism, blood oxidative stress and neopterin levels after ultraendurance exercise. J Sports Sci 32:22-30 | Human | Blood cells Platelet | Oxidative stress;RONS | |
D'Erchia 2014 Mitochondrion | 2014 | D'Erchia AM, Atlante S, Gadaleta G, Pavesi G, Chiara M, De Virgilio C, Manzari C, Mastropasqua F, Prazzoli GM, Picardi E, Gissi C, Horner D, Reyes A, Sbisa E, Tullo A, Pesole G (2014) Tissue-specific mtDNA abundance from exome data and its correlation 2 with mitochondrial transcription, mass and respiratory activity. Mitochondrion 970:1-9. | Human | |||
Gaude 2014 Cancer Metab | 2014 | Gaude E, Frezza C (2014) Defects in mitochondrial metabolism and cancer. Cancer Metab 2:10. | Human | Cancer | ||
Paradies 2014 Biochim Biophys Acta | 2014 | Paradies G, Paradies V, De Benedictis V, Ruggiero FM, Petrosillo G (2014) Functional role of cardiolipin in mitochondrial bioenergetics. Biochim Biophys Acta 1837:408-17. | Cell death Permeability transition | |||
Mourier 2014 Hum Mol Genet | 2014 | Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG (2014) Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet 23:2580-92. | Mouse | Heart | Oxidative stress;RONS | Neurodegenerative |
Boczek 2014 Biomed Res Int | 2014 | Boczek T, Lisek M, Ferenc B, Kowalski A, Wiktorska M, Zylinska L (2014) Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells. Biomed Res Int 2014:735106. | Rat | Nervous system Other cell lines | ||
Quoilin 2014 Dissertation | 2014 | Quoilin C (2014) Les effets délétères métaboliques et oxydants induits lors d'un sepsis sur la fonction rénale. Dissertation 1-195. | Kidney Endothelial;epithelial;mesothelial cell | Cell death Ischemia-reperfusion Oxidative stress;RONS | Sepsis | |
Pulliam 2014 Biochem J | 2014 | Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H (2014) Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Biochem J 462:359-71. | Mouse | Heart Skeletal muscle | Mitochondrial disease | |
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Weber 2013 Thesis East Carolina University | 2013 | Weber T (2013) The effect of contractile activity and substrate challenges on metabolic flexibility in human primary myotubes. Thesis East Carolina University - USA:105 pp. | Human | Skeletal muscle Other cell lines | Obesity | |
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Alandijany 2013 J Neurovirol | 2013 | Alandijany T, Kammouni W, Roy Chowdhury SK, Fernyhough P, Jackson AC (2013) Mitochondrial dysfunction in rabies virus infection of neurons. J Neurovirol 19:537-49. | Rat | Nervous system | Oxidative stress;RONS | Infectious |
Kristensen 2013 PLoS One | 2013 | Kristensen JM, Larsen S, Helge JW, Dela F, Wojtaszewski JFP (2013) Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS One 8:e53533. | Mouse | Skeletal muscle | Diabetes | |
Iglesias-Gonzalez 2012 Neurochem Res | 2012 | Iglesias-Gonzalez J, Sanchez-Iglesias S, Mendez-Alvarez E, Rose S, Hikima A, Jenner P, Soto-Otero R (2012) Differential toxicity of 6-hydroxydopamine in SH-SY5Y human neuroblastoma cells and rat brain mitochondria: protective role of catalase and superoxide dismutase. Neurochem Res 37:2150-60. | Rat | Nervous system | Oxidative stress;RONS Mitochondrial disease | Neurodegenerative Parkinson's |
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Hroudova 2012 European Psychiatry | 2012 | Hroudova J, Fisar Z, Korabecny J, Kuca K, Jirak R, Raboch J (2012) P-451 - changes of cellular respiration in patients with Alzheimer's disease. European Psychiatry 27:01. | Human | Blood cells Platelet | Alzheimer's Neurodegenerative | |
Moon 2012 J Biol Chem | 2012 | Moon SH, Jenkins CM, Kiebish MA, Sims HF, Mancuso DJ, Gross RW (2012) Genetic ablation of calcium-independent phospholipase A2γ (iPLA2γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release. J Biol Chem 287:29837-50. | Mouse | Liver | Cell death Permeability transition | |
Kucera 2012 J Gastroenterol Hepatol | 2012 | Kucera O, Rousar T, Stankova P, Hanackova L, Lotkova H, Podhola M, Cervinkova Z (2012) Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. J Gastroenterol Hepatol 27:323-30. | Rat | Liver | Oxidative stress;RONS | |
Oellermann 2012 J Exp Biol | 2012 | Oellermann M, Poertner HO, Mark FC (2012) Mitochondrial dynamics underlying thermal plasticity of cuttlefish (Sepia officinalis) hearts. J Exp Biol 215:2992-3000. | Molluscs | Heart | Ischemia-reperfusion | |
Wuest 2012 Am J Physiol Heart Circ Physiol | 2012 | Wuest RC, Myers DS, Stones R, Benoist D, Robinson PA, Boyle JP, Peers C, White E, Rossiter HB (2012) Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure. Am J Physiol Heart Circ Physiol 302: H402-H411. | Rat | Skeletal muscle | Cryopreservation | |
Acuña-Castroviejo 2012 Age (Dordr) | 2012 | Acuña-Castroviejo D, Carretero M, Doerrier C, López LC, García-Corzo L, Tresguerres JA, Escames G (2012) Melatonin protects lung mitochondria from aging. Age (Dordr) 34(3):681-92. | Mouse | Lung;gill | Aging;senescence | |
Larsen 2012 J Physiol | 2012 | Larsen S, Nielsen J, Neigaard Nielsen C, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel RC, Helge JW, Dela F, Hey-Mogensen M (2012) Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol 590:3349-60. | Human | Skeletal muscle | ||
Bustamante 2012 Alcohol | 2012 | Bustamante J, Karadayian AG, Lores-Arnaiz S, Cutrera RA (2012) Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover. Alcohol 46:473-9. | Mouse | Nervous system | Oxidative stress;RONS | |
Vuda 2012 Innate Immun | 2012 | Vuda M, Brander L, Schröder R, Jakob SM, Takala J, Djafarzadeh S (2012) Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs. Innate Immun 18:217-30. | Pig | Skeletal muscle Liver | ||
Galli 2012 J Therm Biol | 2012 | Galli GL, Richards JG (2012) The effect of temperature on mitochondrial respiration in permeabilized cardiac fibers from the freshwater turtle, Trachemys scripta. J Ther Bio 37:195–200. | Reptiles | Heart | ||
Gutierrez 2012 Hum Mutat | 2012 | Gutiérrez Cortés N, Pertuiset C, Dumon E, Börlin M, Hebert-Chatelain E, Pierron D, Feldmann D, Jonard L, Marlin S, Letellier T, Rocher C (2012) Novel mitochondrial DNA mutations responsible for maternally inherited non-syndromic hearing loss. Hum Mutat 33:681-9 | Human | Inherited | ||
Mark 2012 PLoS One | 2012 | Mark FC, Lucassen M, Strobel A, Barrera-Oro E, Koschnick N, Zane L, Patarnello T, Pörtner HO, Papetti C (2012) Mitochondrial function in Antarctic Nototheniids with ND6 translocation. PLoS One 7:e31860 | Fishes | Liver | ||
Simonin 2012 Biochem J | 2012 | Simonin V, Galina A (2012) Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner. Biochem J 449:263-73. | Plants | |||
Freyer 2012 Nat Genet | 2012 | Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF (2012) Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 44:1282-5. | Mouse | Heart Liver | ||
Welchen 2012 Biochim Biophys Acta | 2012 | Welchen E, Hildebrandt TM, Lewejohann D, Gonzalez DH, Braun HP (2012) Lack of cytochrome c in Arabidopsis decreases stability of Complex IV and modifies redox metabolism without affecting Complexes I and III. Biochim Biophys Acta 1817:990-1001. | Plants | Oxidative stress;RONS | ||
Aoun 2012 J Bioenerg Biomembr | 2012 | Aoun M, Fouret G, Michel F, Bonafos B, Ramos J, Cristol JP, Carbonneau MA, Coudray C, Feillet-Coudray C (2012) Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease. J Bioenerg Biomembr 44:439-52. | Rat | Liver | Other | |
Aoun 2012 Br J Nutr | 2012 | Aoun M, Feillet-Coudray C, Fouret G, Chabi B, Crouzier D, Ferreri C, Chatgilialoglu C, Wrutniak-Cabello C, Cristol JP, Carbonneau MA, Coudray C (2012) Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect of different nutritional lipid patterns. Br J Nutr 107:647-59. | Rat | Liver | Other | |
Groeger 2012 Shock | 2012 | Groeger M, Matallo J, McCook O, Wagner F, Wachter U, Bastian O, Gierer S, Reich V, Stahl B, Huber-Lang M, Szabó C, Georgieff M, Radermacher P, Calzia E, Wagner K (2012) Temperature and cell-type dependency of sulfide effects on mitochondrial respiration. Shock 38:367-74. | Macrophage-derived | |||
Goo 2012 PLoS One | 2012 | Goo CK, Lim HY, Ho QS, Too HP, Clement MV, Wong KP (2012) PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. PLoS One 7:e45806. | Mouse | Fibroblast | ||
Picard 2012 PLoS One | 2012 | Picard M, Wright KJ, Ritchie D, Thomas MM, Hepple RT (2012) Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One 7:e43003. | Rat | Heart | Oxidative stress;RONS | Aging;senescence |
Niehusmann 2011 Epilepsy Behav | 2011 | Niehusmann P, Surges R, von Wrede RD, Elger CE, Wellmer J, Reimann J, Urbach H, Vielhaber S, Bien CG, Kunz WS (2011) Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery. Epilepsy Behav 20:38-43. | Human | Skeletal muscle Nervous system | Other | |
Bratic 2011 PLoS Genet | 2011 | Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG (2011) The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet 7:e1002324. | Drosophila | |||
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Tweedie 2011 Am J Physiol Regul Integr Comp Physiol | 2011 | Kane C, Romestaing C, Burelle Y, Safdar A, Tarnopolsky MA, Seadon S, Britton SL, Koch LG, Hepple RT (2011) Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol 300:R544-53. | Rat | Skeletal muscle | Oxidative stress;RONS | |
Naimi 2011 Clin Physiol Funct Imaging | 2011 | Naimi AI, Bourbeau J, Perrault H, Baril J, Wright-Paradis C, Rossi A, Taivassalo T, Sheel AW, Rabøl R, Dela F, Boushel RC (2011) Altered mitochondrial regulation in quadriceps muscles of patients with COPD. Clin Physiol Funct Imaging 31:124-31. | Human | Skeletal muscle | Mitochondrial disease | COPD |
Strub 2011 FASEB J | 2011 | Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S (2011) Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate Complex IV assembly and respiration. FASEB J 25:600-12. | Mouse | Heart | ||
Robin 2011 J Bacteriol | 2011 | Robin S, Arese M, Forte E, Sarti P, Giuffrè A, Soulimane T (2011) A sulfite respiration pathway from Thermus thermophilus and the key role of newly identified cytochrome c550. J Bacteriol 193:3988-97. | Eubacteria | |||
Rosca 2011 Biochim Biophys Acta | 2011 | Rosca M, Minkler P, Hoppel CL (2011) Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of Complex IV. Biochim Biophys Acta 1807:1373-82. | Rat Dog | Heart | Ischemia-reperfusion | |
Djafarzadeh 2011 Mitochondrion | 2011 | Djafarzadeh S, Vuda M, Takala J, Ochs M, Jakob SM (2011) Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion 11:83-8. | Human | Liver | ||
Van Bergen 2011 PLoS One | 2011 | Van Bergen NJ, Crowston JG, Kearns LS, Staffieri SE, Hewitt AW, Cohn AC, Mackey DA, Trounce IA (2011) Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. PLoS One 6:e21347. | Human | Nervous system Islet cell;pancreas;thymus | Mitochondrial disease | |
Johansson 2011 Biochim Biophys Acta | 2011 | Johansson AL, Chakrabarty S, Berthold CL, Högbom M, Warshel A, Brzezinski P (2011) Proton-transport mechanisms in cytochrome c oxidase revealed by studies of kinetic isotope effects. Biochim Biophys Acta 1807:1083-94. | Eubacteria | |||
Oliva 2011 PloS One | 2011 | Oliva CR, Moellering DR, Gillespie GY, Griguer CE (2011) Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production. PloS One 6:e24665. | Human | Nervous system | Oxidative stress;RONS | Cancer |
Pasdois 2011 Biochem J | 2011 | Pasdois P, Parker JE, Griffiths EJ, Halestrap AP (2011) The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Biochem J 436:493-505. | Rat | Heart | Ischemia-reperfusion Oxidative stress;RONS | |
Viader 2011 J Neurosci | 2011 | Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J (2011) Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40. | Mouse | Nervous system | Neurodegenerative | |
Chowdhury 2010 Am J Physiol Endocrinol Metab | 2010 | Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX (2010) Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab 298:E89-98. | Pig | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS Mitochondrial disease | |
Aguirre 2010 Biochim Biophys Acta | 2010 | Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65. https://doi.org/10.1016/j.bbabio.2010.01.033 | HEK | Oxidative stress;RONS | ||
Dikov 2010 Exp Gerontol | 2010 | Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95. | HeLa Fibroblast HUVEC | Oxidative stress;RONS | Aging;senescence | |
Wang 2010 Stem Cells | 2010 | Wang W, Osenbroch P, Skinnes R, Esbensen Y, Bjoeraas M, Eide L (2010) Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells. Stem Cells 28:2195-204. | Nervous system Stem cells | |||
Rhein 2010 PloS One | 2010 | Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A (2010) Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PloS One 5:e12359. | Neuroblastoma | Aging;senescence Alzheimer's Neurodegenerative | ||
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Fornunskova 2010 Biochem J | 2010 | Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J (2010) Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. Biochem J 428:363-74. | Human | HEK | ||
Groeger 2010 Crit Care | 2010 | Groeger M, Wagner F, Baumgart K, Huber-Lang M, Knoeferl M, Georgieff M, Radermacher P, Szabo C, Calzia E (2010) Mitochondrial respiration and cytochrome c inhibition by sulfide in peritoneal macrophages in vitro: Effects of temperature and pH. Crit Care 14:P6. | Macrophage-derived | |||
Pichaud 2010 J Exp Biol | 2010 | Pichaud N, Chatelain EH, Ballard JWO, Tanguay R, Morrow G, Blier PU (2010)Thermal sensitivity of mitochondrial metabolism in two distinct mitotypes of Drosophila simulans: Evaluation of mitochondrial plasticity. J Exp Biol 213:1665-75. | Drosophila | Skeletal muscle | ||
Nuskova 2010 J Bioenerg Biomembr | 2010 | Nůsková H, Vrbacký M, Drahota Z, Houštěk J (2010) Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase. J Bioenerg Biomembr 42:395-403. | ||||
Lim 2010 Proteomics | 2010 | Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Goetz J (2010) Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10:1621-33. | Human | Nervous system | Oxidative stress;RONS | Aging;senescence Alzheimer's Diabetes Neurodegenerative |
Jones 2010 Biochim Biophys Acta | 2010 | Jones TT, Brewer GJ (2010) Age-related deficiencies in Complex I endogenous substrate availability and reserve capacity of Complex IV in cortical neuron electron transport. Biochim Biophys Acta 1797:167-76. | Rat | Nervous system | Aging;senescence Neurodegenerative | |
Guillet 2010 Mitochondrion | 2010 | Guillet V, Chevrollier A, Cassereau J, Letournel F, Gueguen N, Richard L, Desquiret V, Verny C, Procaccio V, Amati-Bonneau P, Reynier P, Bonneau D (2010) Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity. Mitochondrion 10:115-24. | Human | Fibroblast | Neurodegenerative | |
Freyer 2010 Nucleic Acids Res | 2010 | Freyer C, Park CB, Ekstrand MI, Shi Y, Khvorostova J, Wibom R, Falkenberg M, Gustafsson CM, Larsson NG (2010) Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription. Nucleic Acids Res 38:6577–88. | Mouse | Heart | Cardiovascular | |
Xie 2010 Acta Biochim Pol | 2010 | Xie X, Chowdhury SR, Sangle G, Shen GX (2010) Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cells. Acta Biochim Pol 57:393-8. | Pig | Endothelial;epithelial;mesothelial cell | Diabetes | |
Fernyhough 2010 Expert Rev Endocrinol Metab | 2010 | Fernyhough P, Roy Chowdhury SK, Schmidt RE (2010) Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Rev Endocrinol Metab 5:39-49. | Rat | Nervous system | Diabetes | |
Kotarsky 2010 Mitochondrion | 2010 | Kotarsky H, Karikoski R, Mörgelin M, Marjavaara S, Bergman P, Zhang DL, Smet J, van Coster R, Fellman V (2010) Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation. Mitochondrion 10:497-509. | Human | Fibroblast | Inherited | |
Ahting 2009 Biochim Biophys Acta | 2009 | Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T (2009) Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta 1787:371-76. | Mouse | Stem cells | Other | |
Rhein 2009 Cell Mol Neurobiol | 2009 | Rhein V, Baysang G, Rao S, Meier F, Bonert A, Müller-Spahn F, Eckert A (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29:1063-71. | Human | Nervous system Neuroblastoma | Alzheimer's Neurodegenerative | |
Nouette-Gaulain 2009 Anesthesiology | 2009 | Nouette-Gaulain K, Bellance N, Prévost B, Passerieux E, Pertuiset C, Galbes O, Smolkova K, Masson F, Miraux S, Delage JP, Letellier T, Rossignol R, Capdevila X, Sztark F (2009) Erythropoietin protects against local anesthetic myotoxicity during continuous regional analgesia. Anesthesiology 110:648-59. | Human Rat | Skeletal muscle Nervous system | ||
Jones 2009 Exp Neurol | 2009 | Jones TT, Brewer GJ (2009) Critical age-related loss of cofactors of neuron cytochrome c oxidase reversed by estrogen. Exp Neurol 215:212-9. | Rat | Nervous system | Mitochondrial disease | |
Flamment 2009 Am J Physiol Endocrinol Metab | 2009 | Flamment M, Gueguen N, Wetterwald C, Simard G, Malthièry Y, Ducluzeau PH (2009) Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 297:E1162-70. | Rat | Liver | ||
Goncalves 2009 PLoS One | 2009 | Gonçalves RL, Machado AC, Paiva-Silva GO, Sorgine MH, Momoli MM, Oliveira JH, Vannier-Santos MA, Galina A, Oliveira PL, Oliveira MF (2009) Blood-feeding induces reversible functional changes in flight muscle mitochondria of Aedes aegypti mosquito. PLoS One 4:e7854. | Hexapods | Skeletal muscle | ||
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Gupte 2009 Diabetes | 2009 | Gupte AA, Bomhoff GL, Swerdlow RH, Geiger PC (2009) Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes 58:567-78. | Rat | Skeletal muscle | Diabetes | |
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Eimre 2008 Biochim Biophys Acta | 2008 | Eimre M, Paju K, Pelloux S, Beraud N, Roosimaa M, Kadaja L, Gruno M, Peet N, Orlova E, Remmelkoor R, Piirsoo A, Saks V, Seppet E (2008) Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochim Biophys Acta 1777:514-24. | Rat | Heart | ||
Masci 2008 Biochim Biophys Acta | 2008 | Masci A, Mastronicola D, Arese M, Piane M, De Amicis A, Blanck TJ, Chessa L, Sarti P (2008) Control of cell respiration by nitric oxide in Ataxia Telangiectasia lymphoblastoid cells. Biochim Biophys Acta 1777:66-73. | Human | Nervous system | Oxidative stress;RONS | |
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