Template:Keywords: Coupling control: Difference between revisions

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{| class="wikitable"
{| class="wikitable"
|-
|-
! Name !! Definition !! Icon
! Respiratory rate !! Definition !! Icon
|-
|-
| [[OXPHOS-capacity]] || ''P'' = ''P´''-''Rox'' || [[File:P.jpg |link=OXPHOS-capacity]]
| [[OXPHOS-capacity]] || ''P'' = ''P´''-''Rox'' || [[File:P.jpg |link=OXPHOS-capacity]]
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| [[ROUTINE-respiration]] || ''R'' = ''R´''-''Rox'' || [[File:R.jpg |link=ROUTINE-respiration]]
| [[ROUTINE-respiration]] || ''R'' = ''R´''-''Rox'' || [[File:R.jpg |link=ROUTINE-respiration]]
|-
|-
| [[ET-capacity]] || ''E'' = ''E´''-''Rox'' || [[File:E.jpg |link=ET-capacity]]
| [[ET-capacity]] || ''E'' = ''E´''-''Rox'' || [[File:E.jpg |link=ET-capacity]] || » [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref>
|}
|-
::::::» [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref>
| [[LEAK-respiration]] || ''L'' = ''L´''-''Rox'' || [[File:L.jpg |link=LEAK-respiration]] || » [[LEAK-state with ATP]]
{| class="wikitable"
|-
|  ||  ||  || » [[LEAK-state with oligomycin]]
|-
|-
| [[LEAK-respiration]] || ''L'' = ''L´''-''Rox'' || [[File:L.jpg |link=LEAK-respiration]]
| || || || » [[LEAK-state without adenylates]]
|}
::::::» [[LEAK-state with ATP]]
::::::» [[LEAK-state with oligomycin]]
::::::» [[LEAK-state without adenylates]]
{| class="wikitable"
|-
|-
| [[Residual oxygen consumption]] ''Rox'' || ''L'' = ''L´''-''Rox'' || [[File:ROX.jpg |link=Residual oxygen consumption]]
| [[Residual oxygen consumption]] ''Rox'' || ''L'' = ''L´''-''Rox'' || [[File:ROX.jpg |link=Residual oxygen consumption]]
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:::* Chance and Williams nomenclature: respiratory states
:::* Chance and Williams nomenclature: respiratory states
::::» [[State 1]]
::::» [[State 1]] —» [[State 2]] —» [[State 3]] —» [[State 4]] —» [[State 5]]
::::» [[State 2]]
::::» [[State 3]]
::::» [[State 4]]
::::» [[State 5]]


=== Flux control ratios related to coupling in mt-preparations and living cells ===
=== Flux control ratios related to coupling in mt-preparations and living cells ===
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:::» [[Coupling-control ratio]]
:::» [[Coupling-control ratio]]


:::: [[Image:L over P.jpg|50 px|link=L/P coupling control ratio |''L/P'' coupling control ratio]] [[L/P coupling control ratio |''L/P'' coupling control ratio]], ''L/P''
{| class="wikitable"
:::::::» [[Respiratory acceptor control ratio]], RCR = ''P/L''
|-
:::: [[Image:L over R.jpg|50 px|link=L/R coupling control ratio |''L/R'' coupling control ratio]] [[L/R coupling control ratio |''L/R'' coupling control ratio]], ''L/R''
! ''FCR'' !! Definition !! Icon
:::: [[Image:L over E.jpg|50 px|link=L/E coupling control ratio |''L/E'' coupling control ratio]] [[L/E coupling control ratio |''L/E'' coupling control ratio]], ''L/E''
|-
:::::::» [[Uncoupling-control ratio]], UCR = ''E/L''
| [[L/P coupling control ratio |''L/P'' coupling control ratio]] || ''L/P'' || [[Image:L over P.jpg|50 px|link=L/P coupling control ratio |''L/P'' coupling control ratio]] || » [[Respiratory acceptor control ratio]], RCR = ''P/L''
:::: [[Image:P over E.jpg|50 px|link=P/E control ratio |''P/E'' control ratio]] [[P/E control ratio |''P/E'' control ratio]], ''P/E''
|-
:::: [[Image:R over E.jpg|50 px|link=R/E control ratio |''R/E'' control ratio]] [[R/E control ratio |''R/E'' control ratio]], ''R/E''
| [[L/R coupling control ratio |''L/R'' coupling control ratio]] || ''L/R'' || [[Image:L over R.jpg|50 px|link=L/R coupling control ratio |''L/R'' coupling control ratio]]
 
|-
:::: [[Image:NetP over E.jpg|60 px|link=net P/E control ratio |net ''P/E'' control ratio]] [[net P/E control ratio |net ''P/E'' control ratio]], (''P-L'')/''E''
| [[L/E coupling control ratio |''L/E'' coupling control ratio]] || ''L/E'' || [[Image:L over E.jpg|50 px|link=L/E coupling control ratio |''L/E'' coupling control ratio]] || » [[Uncoupling-control ratio]], UCR = ''E/L''
:::: [[Image:NetR over E.jpg|60 px|link=net R/E control ratio |net ''R/E'' control ratio]] [[net R/E control ratio |net ''R/E'' control ratio]], (''R-L'')/''E''
|-
 
| [[P/E control ratio |''P/E'' control ratio]] || ''P/E'' || [[Image:P over E.jpg|50 px|link=P/E control ratio |''P/E'' control ratio]]
|-
| [[R/E control ratio |''R/E'' control ratio]] || ''R/E'' || [[Image:R over E.jpg|50 px|link=R/E control ratio |''R/E'' control ratio]]
|-
| [[net P/E control ratio |net ''P/E'' control ratio]] || (''P-L'')/''E'' || [[Image:NetP over E.jpg|60 px|link=net P/E control ratio |net ''P/E'' control ratio]]
|-
| [[net R/E control ratio |net ''R/E'' control ratio]] || (''R-L'')/''E'' || [[Image:NetR over E.jpg|60 px|link=net R/E control ratio |net ''R/E'' control ratio]]
|}


=== Net, excess, and reserve capacities of respiration ===
=== Net, excess, and reserve capacities of respiration ===

Revision as of 18:50, 10 November 2020

  • The Blue Book 2020
    The Blue Book 2020
  • OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.

    OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.

  • 4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».

    4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».

  • Flux control ratios related to coupling.png
  • Net, excess, and reserve capacities PREL.png
  • (P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.

    (P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.


Questions.jpg


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Mitochondrial and cellular respiratory rates in coupling control states

OXPHOS-coupled energy cycles. Source: The Blue book
Respiratory rate Definition Icon
OXPHOS-capacity P = P´-Rox P.jpg
ROUTINE-respiration R = R´-Rox R.jpg
ET-capacity E = E´-Rox E.jpg » Noncoupled respiration - Uncoupler[1]
LEAK-respiration L = L´-Rox L.jpg » LEAK-state with ATP
» LEAK-state with oligomycin
» LEAK-state without adenylates
Residual oxygen consumption Rox L = L´-Rox ROX.jpg
  • Chance and Williams nomenclature: respiratory states
» State 1 —» State 2 —» State 3 —» State 4 —» State 5

Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio
» Coupling-control ratio
FCR Definition Icon
L/P coupling control ratio L/P L/P coupling control ratio » Respiratory acceptor control ratio, RCR = P/L
L/R coupling control ratio L/R L/R coupling control ratio
L/E coupling control ratio L/E L/E coupling control ratio » Uncoupling-control ratio, UCR = E/L
P/E control ratio P/E P/E control ratio
R/E control ratio R/E R/E control ratio
net P/E control ratio (P-L)/E net P/E control ratio
net R/E control ratio (R-L)/E net R/E control ratio

Net, excess, and reserve capacities of respiration

Net OXPHOS-capacity P-L Net OXPHOS-capacity P-L, P-L
Net ROUTINE-activity R-L Net ROUTINE-activity R-L, R-L
Net ET-capacity E-L Net ET-capacity E-L, E-L
ET-excess capacity E-P ET-excess capacity E-P, E-P
ET-reserve capacity E-R ET-reserve capacity E-R, E-R


Flux control efficiencies related to coupling control ratios

» Flux control efficiency jZ-Y
OXPHOS-coupling efficiency P-L OXPHOS-coupling efficiency P-L, jP-L = (P-L)/P = 1-L/P
ROUTINE-coupling efficiency R-L ROUTINE-coupling efficiency R-L, jR-L = (R-L)/R = 1-L/R
ET-coupling efficiency E-L ET-coupling efficiency E-L, jE-L = (E-L)/E = 1-L/E
» Biochemical coupling efficiency
ET-excess control efficiency E-P ET-excess control efficiency E-P, jE-P = (E-P)/E = 1-P/E
ET-reserve control efficiency E-R ET-reserve control efficiency E-R, jE-R = (E-R)/E = 1-R/E


General

» Background state
» Basal respiration
» Baseline state
» Coupling-control protocol
» Dyscoupled respiration
» Dyscoupling
» Electron leak
» Electron-transfer-pathway state
» Level flow
» Metabolic control variable
» Oxidative phosphorylation
» Oxygen flow
» Oxygen flux
» Permeabilized cells
» Phosphorylation system
» Proton leak
» Proton slip
» Reference state
» Respiratory state
» Static head
» Uncoupling


  1. ↑ Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »Uncoupler«
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