Dyscoupled respiration

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Dyscoupled respiration


Dyscoupled respiration is LEAK respiration distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.

In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.

Reference: Gnaiger 2020 BEC MitoPathways

Communicated by Gnaiger E 2010-10-19, edited 2012-10-31

Coupling efficiency: from 0 to <1


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Β» Artefacts by single dose uncoupling
Β» ATP synthase
Β» Coupling-control protocol
Β» Dyscoupled respiration
Β» Is respiration uncoupled - noncoupled - dyscoupled?
Β» Noncoupled respiration: Discussion
Β» Uncoupler
Β» Uncoupled respiration - see Β» Noncoupled respiration
Β» Uncoupling proteins
Β» Uncoupling protein 1
Β» Uncoupler titrations - Optimum uncoupler concentration
Respiratory states and control ratios
Β» Biochemical coupling efficiency
Β» Coupling-control state
Β» Electron-transfer-pathway state
Β» Electron-transfer pathway
E.jpg ET capacity
Β» E-L coupling efficiency
Β» Flux control efficiency
Β» Flux control ratio
Β» LEAK-control ratio
Β» LEAK respiration
Β» Noncoupled respiration
Β» OXPHOS capacity; Β» State 3
Β» OXPHOS-control ratio, P/E ratio
Β» Respiratory acceptor control ratio
Β» ROUTINE-control ratio
Β» ROUTINE respiration
Β» ROUTINE state
Β» State 3u
Β» State 4
Β» Uncoupling-control ratio UCR
General (alphabetical order)
Β» Adenine nucleotide translocase
Β» Adenylates
Β» Electron transfer pathway
Β» Mitochondrial preparations
Β» mt-membrane potential
Β» Oxygen flux
Β» Phosphorylation system
Β» Proton leak
Β» Proton slip
Β» TIP2k
Other keyword lists
Β» Template:Keywords: Force and membrane potential

MitoPedia concepts: Respiratory state, Recommended 

MitoPedia methods: Respirometry 

MitoPedia topics: EAGLE 

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