Template:Keywords: Coupling control: Difference between revisions
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== Mitochondrial and cellular respiratory rates in coupling control states == | == Mitochondrial and cellular respiratory rates in coupling control states == | ||
[[Image:OXPHOS-coupled energy cycles.jpg|right|300px||link=Gnaiger 2020 MitoPathways|OXPHOS-coupled energy cycles. Source: The Blue book]] | |||
:::: [[File:P.jpg |link=OXPHOS-capacity]] [[OXPHOS-capacity]] ''P'' = ''P´''-''Rox'' | :::: [[File:P.jpg |link=OXPHOS-capacity]] [[OXPHOS-capacity]] ''P'' = ''P´''-''Rox'' | ||
:::: [[File:R.jpg |link=ROUTINE-respiration]] [[ROUTINE-respiration]] ''R'' = ''R´''-''Rox'' | :::: [[File:R.jpg |link=ROUTINE-respiration]] [[ROUTINE-respiration]] ''R'' = ''R´''-''Rox'' | ||
:::: [[File:E.jpg |link=ET-capacity]] [[ET-capacity]] ''E'' = ''E´''-''Rox'' | :::: [[File:E.jpg |link=ET-capacity]] [[ET-capacity]] ''E'' = ''E´''-''Rox'' | ||
::::::» [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref> | |||
:::: [[File:L.jpg |link=LEAK-respiration]] [[LEAK-respiration]] ''L'' = ''L´''-''Rox'' | :::: [[File:L.jpg |link=LEAK-respiration]] [[LEAK-respiration]] ''L'' = ''L´''-''Rox'' | ||
::::» [[LEAK-state with ATP]] | ::::::» [[LEAK-state with ATP]] | ||
::::» [[LEAK-state with oligomycin]] | ::::::» [[LEAK-state with oligomycin]] | ||
::::» [[LEAK-state without adenylates]] | ::::::» [[LEAK-state without adenylates]] | ||
:::: [[File:ROX.jpg |link=Residual oxygen consumption]] [[Residual oxygen consumption]] ''Rox'' | :::: [[File:ROX.jpg |link=Residual oxygen consumption]] [[Residual oxygen consumption]] ''Rox'' | ||
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== Flux control ratios related to coupling in mt-preparations and living cells == | == Flux control ratios related to coupling in mt-preparations and living cells == | ||
:::» [[Flux control ratio]] | |||
:::» [[Coupling-control ratio]] | |||
:::: [[Image:L over P.jpg|50 px|link=L/P coupling control ratio |''L/P'' coupling control ratio]] [[L/P coupling control ratio |''L/P'' coupling control ratio]], ''L/P'' | :::: [[Image:L over P.jpg|50 px|link=L/P coupling control ratio |''L/P'' coupling control ratio]] [[L/P coupling control ratio |''L/P'' coupling control ratio]], ''L/P'' | ||
:::::» [[ | :::::::» [[Respiratory acceptor control ratio]], RCR = ''P/L'' | ||
:::: [[Image:L over R.jpg|50 px|link=L/R coupling control ratio |''L/R'' coupling control ratio]] [[L/R coupling control ratio |''L/R'' coupling control ratio]], ''L/R'' | :::: [[Image:L over R.jpg|50 px|link=L/R coupling control ratio |''L/R'' coupling control ratio]] [[L/R coupling control ratio |''L/R'' coupling control ratio]], ''L/R'' | ||
:::: [[Image:L over E.jpg|50 px|link=LEAK-control ratio |LEAK-control ratio]] [[LEAK-control ratio]], ''L/E'' | :::: [[Image:L over E.jpg|50 px|link=LEAK-control ratio |LEAK-control ratio]] [[LEAK-control ratio]], ''L/E'' | ||
:::::» [[ | :::::::» [[Uncoupling-control ratio]], UCR = ''E/L'' | ||
:::: [[Image:P over E.jpg|50 px|link=OXPHOS-control ratio |OXPHOS-control ratio]] [[OXPHOS-control ratio]], ''P/E'' | :::: [[Image:P over E.jpg|50 px|link=OXPHOS-control ratio |OXPHOS-control ratio]] [[OXPHOS-control ratio]], ''P/E'' | ||
:::: [[Image:R over E.jpg|50 px|link=ROUTINE-control ratio |ROUTINE-control ratio]] [[ROUTINE-control ratio]], ''R/E'' | :::: [[Image:R over E.jpg|50 px|link=ROUTINE-control ratio |ROUTINE-control ratio]] [[ROUTINE-control ratio]], ''R/E'' | ||
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== Flux control efficiencies related to coupling control ratios == | == Flux control efficiencies related to coupling control ratios == | ||
:::» [[Flux control efficiency]] ''j<sub>Z-Y</sub>'' | |||
:::: [[Image:j--P.jpg|50 px|link=OXPHOS-coupling efficiency P-L |OXPHOS-coupling efficiency P-L]] [[OXPHOS-coupling efficiency P-L]], ''j<sub>P-L</sub>'' = (''P-L'')/''P'' = 1-''L/P'' | :::: [[Image:j--P.jpg|50 px|link=OXPHOS-coupling efficiency P-L |OXPHOS-coupling efficiency P-L]] [[OXPHOS-coupling efficiency P-L]], ''j<sub>P-L</sub>'' = (''P-L'')/''P'' = 1-''L/P'' | ||
:::: [[Image:j--R.jpg|50 px|link=ROUTINE-coupling efficiency R-L |ROUTINE-coupling efficiency R-L]] [[ROUTINE-coupling efficiency R-L]], ''j<sub>R-L</sub>'' = (''R-L'')/''R'' = 1-''L/R'' | :::: [[Image:j--R.jpg|50 px|link=ROUTINE-coupling efficiency R-L |ROUTINE-coupling efficiency R-L]] [[ROUTINE-coupling efficiency R-L]], ''j<sub>R-L</sub>'' = (''R-L'')/''R'' = 1-''L/R'' | ||
:::: [[Image:j--E.jpg|50 px|link=ET-coupling efficiency |ET-coupling efficiency E-L]] [[ET-coupling efficiency E-L]], ''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' | :::: [[Image:j--E.jpg|50 px|link=ET-coupling efficiency |ET-coupling efficiency E-L]] [[ET-coupling efficiency E-L]], ''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' | ||
:::::» [[Biochemical coupling efficiency]] | :::::::» [[Biochemical coupling efficiency]] | ||
:::: [[Image:jExP.jpg|50 px|link=ET-excess control efficiency E-P]] [[ET-excess control efficiency E-P]], ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = ''1-''P/E'' | :::: [[Image:jExP.jpg|50 px|link=ET-excess control efficiency E-P]] [[ET-excess control efficiency E-P]], ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = ''1-''P/E'' | ||
:::: [[Image:jExR.jpg|50 px|link=ET-reserve control efficiency E-R |ET-reserve control efficiency E-R]] [[ET-reserve control efficiency E-R]], ''j<sub>E-R</sub>'' = (''E-R'')/''E'' = 1-''R/E'' | :::: [[Image:jExR.jpg|50 px|link=ET-reserve control efficiency E-R |ET-reserve control efficiency E-R]] [[ET-reserve control efficiency E-R]], ''j<sub>E-R</sub>'' = (''E-R'')/''E'' = 1-''R/E'' | ||
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::::» [[Basal respiration]] | ::::» [[Basal respiration]] | ||
::::» [[Baseline state]] | ::::» [[Baseline state]] | ||
::::» [[Coupling-control protocol]] | |||
::::» [[Dyscoupled respiration]] | ::::» [[Dyscoupled respiration]] | ||
::::» [[Dyscoupling]] | ::::» [[Dyscoupling]] | ||
::::» [[Electron leak]] | ::::» [[Electron leak]] | ||
::::» [[ | ::::» [[Electron-transfer-pathway state]] | ||
::::» [[Level flow]] | |||
::::» [[ | |||
::::» [[Oxidative phosphorylation]] | ::::» [[Oxidative phosphorylation]] | ||
::::» [[Oxygen flow]] | ::::» [[Oxygen flow]] | ||
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::::» [[Proton leak]] | ::::» [[Proton leak]] | ||
::::» [[Proton slip]] | ::::» [[Proton slip]] | ||
::::» [[Respiratory state]] | ::::» [[Respiratory state]] | ||
::::» [[Static head]] | ::::» [[Static head]] |
Revision as of 05:28, 9 November 2020
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
- Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
Mitochondrial and cellular respiratory rates in coupling control states
- OXPHOS-capacity P = P´-Rox
- ROUTINE-respiration R = R´-Rox
- ET-capacity E = E´-Rox
- LEAK-respiration L = L´-Rox
- L/P coupling control ratio, L/P
- » Respiratory acceptor control ratio, RCR = P/L
- L/R coupling control ratio, L/R
- LEAK-control ratio, L/E
- » Uncoupling-control ratio, UCR = E/L
- OXPHOS-control ratio, P/E
- ROUTINE-control ratio, R/E
- L/P coupling control ratio, L/P
- Net OXPHOS-control ratio, (P-L)/E
- Net ROUTINE-control ratio, (R-L)/E
Net, excess, and reserve capacities of respiration
- Net OXPHOS-capacity P-L, P-L
- Net ROUTINE-activity R-L, R-L
- Net ET-capacity E-L, E-L
- ET-excess capacity E-P, E-P
- » Flux control efficiency jZ-Y
- OXPHOS-coupling efficiency P-L, jP-L = (P-L)/P = 1-L/P
- ROUTINE-coupling efficiency R-L, jR-L = (R-L)/R = 1-L/R
- ET-coupling efficiency E-L, jE-L = (E-L)/E = 1-L/E
- ET-excess control efficiency E-P, jE-P = (E-P)/E = 1-P/E
- ET-reserve control efficiency E-R, jE-R = (E-R)/E = 1-R/E
General
- » Basal respiration
- » Baseline state
- » Coupling-control protocol
- » Dyscoupled respiration
- » Dyscoupling
- » Electron leak
- » Electron-transfer-pathway state
- » Level flow
- » Oxidative phosphorylation
- » Oxygen flow
- » Oxygen flux
- » Permeabilized cells
- » Phosphorylation system
- » Proton leak
- » Proton slip
- » Respiratory state
- » Static head
- » Uncoupling