- high-resolution terminology - matching measurements at high-resolution
MiPMap
Description
The project Mitochondrial Physiology Map (MiPMap) is initiated to provide an overview of mitochondrial properties in cell types, tissues and species. As part of Bioblast, MiPMap may be considered as an information synthase for Comparative Mitochondrial Physiology. Establishing a comprehensive database will require global input and cooperation.
A comparative database of mitochondrial physiology may provide the key for understanding the functional implications of mitochondrial diversity from mouse to man, and evaluation of altered mitochondrial respiratory control patterns in health and disease (Gnaiger 2009).
Abbreviation: MiPMap
MitoPedia methods:
Respirometry,
Fluorometry,
Spectrophotometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.,
Enzyme,
Media for respirometry,
Inhibitor,
Substrate and metabolite,
Uncoupler,
Permeabilization agent
MiPMap labels
MiPMap labels provide the backbone of the MiPMap project. The MiPMap labels can be considered as keywords which can be attached to various sources of information (publications). With proper labelling, multidimensional maps of information can be constructed, filtering the sources through various grids.
The MiPMap labels (filters) are grouped into various topics (properties).
MiP areas
- Respiration :••: Instruments;methods :••: mt-Biogenesis;mt-density :••: mt-Structure;fission;fusion :••: mt-Membrane :••: mtDNA;mt-genetics :••: nDNA;cell genetics :••: Genetic knockout;overexpression :••: Comparative MiP;environmental MiP :••: Gender :••: Developmental biology :••: Exercise physiology;nutrition;life style :••: mt-Medicine :••: Patients :••: Pharmacology;toxicology :••: mt-Awareness
Mammals;models
- Human :••: Pig :••: Mouse :••: Rat :••: Guinea pig :••: Bovines :••: Horse :••: Dog :••: Rabbit :••: Cat :••: Other mammals :••: :••: Chicken :••: Zebrafish :••: Drosophila :••: Artemia :••: Caenorhabditis elegans :••: Saccharomyces cerevisiae
Non-mammals
- Birds :••: Reptiles :••: Amphibians :••: Fishes :••: Chelicerates :••: Crustaceans :••: Hexapods :••: Myriapods :••: Annelids :••: Molluscs :••: Nematodes :••: Other invertebrates :••: :••: Fungi :••: Plants :••: Protists :••: Eubacteria :••: Archea
Tissues;cells
- Heart Skeletal muscle Nervous system Liver Kidney Lung;gill Islet Cell; Pancreas; Thymus Endothelial; Epithelial; Mesothelial Cell Blood cells Fat Sex organs
Cell lines
- CHO HEK HeLa Neuroblastoma Fibroblast HUVEC Macrophage-derived Stem cells Other cell lines
Preparations
- Intact Organism Intact Organ Intact cells Permeabilized cells Permeabilized tissue Homogenate Isolated Mitochondria SMP Chloroplasts Enzyme Oxidase; Biochemical Oxidation
Enzymes
- Adenine Nucleotide Translocase Complex I Complex II; Succinate Dehydrogenase Complex III Complex IV; Cytochrome c Oxidase Complex V; ATP Synthase Inner mtMembrane Transporter Marker Enzyme Supercomplex TCA Cycle and Matrix Dehydrogenases Uncoupling protein
Stress conditions
- Cell death Hypoxia Ischemia-Reperfusion; Preservation Permeability transition RONS; Oxidative Stress Temperature
Pathological states
- Aging; senescence Alzheimer's Autism Cancer Cardiovascular COPD Diabetes Inherited Infectious Muscular dystrophy Neurodegenerative Obesity Parkinson's Sepsis Other
Regulation;kinetics
- Aerobic glycolysis ADP ATP; ADP; AMP; PCr ATP ATP production Calcium Coupling efficiency;uncoupling Cyt c Flux control Inhibitor Ion&substrate transport Ion;substrate transport mt-Membrane potential O2 PCr;Cr pH Pi Redox state Substrate Temperature Threshold;excess capacity Uncoupler Substrate; Glucose; TCA Cycle Fatty Acid Amino Acid
Coupling states
- LEAK ROUTINE OXPHOS ETS
Substrate states
- CI CII ETF GpDH CIII CIV CI+II Other combinations ROX High-resolution respirometry: Oxygraph-2k TIP2k Fluorometry pH NO TPP Ca Spectrophotometry O2k-Manual Protocol Theory
High-resolution respirometry - HRR
Additional labels
Publications in the MiPMap: mitochondrial properties in organisms (species), cell types and tissues
Initiation
- Presented at Bioblast 2012.
- Focus for MiPconference on Comparative Mitochondrial Physiology.
- MiP2013 Abstracts
- Link to Mitochondrial Global Network
