Difference between revisions of "MiPMap"
From Bioblast
| Line 33: | Line 33: | ||
=== Tissues;cells === | === Tissues;cells === | ||
: [[Property:Tissue and cell]] | : [[Property:Tissue and cell]] | ||
* Heart | * Heart :••: Skeletal muscle :••: Nervous system :••: Liver :••: Kidney :••: Lung;gill :••: Islet Cell; Pancreas; Thymus :••: Endothelial; Epithelial; Mesothelial Cell :••: Blood cells :••: Fat :••: Sex organs | ||
=== Cell lines === | === Cell lines === | ||
: [[Property:Cell line]] | : [[Property:Cell line]] | ||
* CHO | * CHO :••: HEK :••: HeLa :••: Neuroblastoma :••: Fibroblast :••: HUVEC :••: Macrophage-derived Stem cells :••: Other cell lines | ||
=== Preparations === | === Preparations === | ||
: [[Property:Preparation]] | : [[Property:Preparation]] | ||
* Intact Organism | * Intact Organism :••: Intact Organ :••: Intact cells :••: Permeabilized cells :••: Permeabilized tissue :••: Homogenate :••: Isolated Mitochondria :••: SMP :••: Chloroplasts :••: Enzyme :••: Oxidase; Biochemical Oxidation | ||
=== Enzymes === | === Enzymes === | ||
: [[Property:Enzyme]] | : [[Property:Enzyme]] | ||
* Adenine Nucleotide Translocase | * Adenine Nucleotide Translocase :••: Complex I :••: Complex II; Succinate Dehydrogenase :••: Complex III :••: Complex IV; Cytochrome c Oxidase :••: Complex V; ATP Synthase :••: Inner mtMembrane Transporter :••: Marker Enzyme :••: Supercomplex :••: TCA Cycle and Matrix Dehydrogenases :••: Uncoupling protein | ||
=== Stress conditions === | === Stress conditions === | ||
: [[Property:Stress]] | : [[Property:Stress]] | ||
* Cell death | * Cell death :••: Hypoxia :••: Ischemia-Reperfusion; Preservation :••: Permeability transition :••: RONS; Oxidative Stress :••: Temperature | ||
=== Pathological states === | === Pathological states === | ||
: [[Property:Diseases]] | : [[Property:Diseases]] | ||
* Aging; senescence | * Aging; senescence :••: Alzheimer's :••: Autism :••: Cancer :••: Cardiovascular :••: COPD :••: Diabetes :••: Inherited :••: Infectious :••: Muscular dystrophy :••: Neurodegenerative :••: Obesity :••: Parkinson's :••: Sepsis :••: Other | ||
=== Regulation;kinetics === | === Regulation;kinetics === | ||
: [[Property:Respiration and regulation]] | : [[Property:Respiration and regulation]] | ||
* Aerobic glycolysis | * Aerobic glycolysis :••: ADP :••: ATP; ADP; AMP; PCr :••: ATP :••: ATP production :••: Calcium Coupling efficiency;uncoupling :••: Cyt c :••: Flux control :••: Inhibitor :••: Ion&substrate transport :••: Ion;substrate transport :••: mt-Membrane potential :••: O2 :••: PCr;Cr :••: pH :••: Pi :••: Redox state :••: Substrate :••: Temperature :••: Threshold;excess capacity :••: Uncoupler :••: Substrate; Glucose; TCA Cycle :••: Fatty Acid :••: Amino Acid | ||
=== Coupling states === | === Coupling states === | ||
: [[Property:Coupling states]] | : [[Property:Coupling states]] | ||
* LEAK | * LEAK :••: ROUTINE :••: OXPHOS :••: ETS | ||
=== Substrate states === | === Substrate states === | ||
: [[Property:Substrate states]] | : [[Property:Substrate states]] | ||
* CI | * CI :••: CII :••: ETF :••: GpDH :••: CIII :••: CIV :••: CI+II :••: Other combinations :••: ROX | ||
=== High-resolution respirometry - HRR === | === High-resolution respirometry - HRR === | ||
: [[Property:Instrument and method]] | : [[Property:Instrument and method]] | ||
* High-resolution respirometry: Oxygraph-2k :••: TIP2k :••: Fluorometry :••: pH :••: NO :••: TPP :••: Ca :••: Spectrophotometry :••: O2k-Manual :••: Protocol :••: Theory | |||
=== Additional labels === | === Additional labels === | ||
Revision as of 15:43, 7 June 2014
- high-resolution terminology - matching measurements at high-resolution
MiPMap
Description
The project Mitochondrial Physiology Map (MiPMap) is initiated to provide an overview of mitochondrial properties in cell types, tissues and species. As part of Bioblast, MiPMap may be considered as an information synthase for Comparative Mitochondrial Physiology. Establishing a comprehensive database will require global input and cooperation.
A comparative database of mitochondrial physiology may provide the key for understanding the functional implications of mitochondrial diversity from mouse to man, and evaluation of altered mitochondrial respiratory control patterns in health and disease (Gnaiger 2009).
Abbreviation: MiPMap
MitoPedia methods:
Respirometry,
Fluorometry,
Spectrophotometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.,
Enzyme,
Media for respirometry,
Inhibitor,
Substrate and metabolite,
Uncoupler,
Permeabilization agent
MiPMap labels
MiPMap labels provide the backbone of the MiPMap project. The MiPMap labels can be considered as keywords which can be attached to various sources of information (publications). With proper labelling, multidimensional maps of information can be constructed, filtering the sources through various grids.
The MiPMap labels (filters) are grouped into various topics (properties).
MiP areas
- Respiration :••: Instruments;methods :••: mt-Biogenesis;mt-density :••: mt-Structure;fission;fusion :••: mt-Membrane :••: mtDNA;mt-genetics :••: nDNA;cell genetics :••: Genetic knockout;overexpression :••: Comparative MiP;environmental MiP :••: Gender :••: Developmental biology :••: Exercise physiology;nutrition;life style :••: mt-Medicine :••: Patients :••: Pharmacology;toxicology :••: mt-Awareness
Mammals;models
- Human :••: Pig :••: Mouse :••: Rat :••: Guinea pig :••: Bovines :••: Horse :••: Dog :••: Rabbit :••: Cat :••: Other mammals :••: :••: Chicken :••: Zebrafish :••: Drosophila :••: Artemia :••: Caenorhabditis elegans :••: Saccharomyces cerevisiae
Non-mammals
- Birds :••: Reptiles :••: Amphibians :••: Fishes :••: Chelicerates :••: Crustaceans :••: Hexapods :••: Myriapods :••: Annelids :••: Molluscs :••: Nematodes :••: Other invertebrates :••: :••: Fungi :••: Plants :••: Protists :••: Eubacteria :••: Archea
Tissues;cells
- Heart :••: Skeletal muscle :••: Nervous system :••: Liver :••: Kidney :••: Lung;gill :••: Islet Cell; Pancreas; Thymus :••: Endothelial; Epithelial; Mesothelial Cell :••: Blood cells :••: Fat :••: Sex organs
Cell lines
- CHO :••: HEK :••: HeLa :••: Neuroblastoma :••: Fibroblast :••: HUVEC :••: Macrophage-derived Stem cells :••: Other cell lines
Preparations
- Intact Organism :••: Intact Organ :••: Intact cells :••: Permeabilized cells :••: Permeabilized tissue :••: Homogenate :••: Isolated Mitochondria :••: SMP :••: Chloroplasts :••: Enzyme :••: Oxidase; Biochemical Oxidation
Enzymes
- Adenine Nucleotide Translocase :••: Complex I :••: Complex II; Succinate Dehydrogenase :••: Complex III :••: Complex IV; Cytochrome c Oxidase :••: Complex V; ATP Synthase :••: Inner mtMembrane Transporter :••: Marker Enzyme :••: Supercomplex :••: TCA Cycle and Matrix Dehydrogenases :••: Uncoupling protein
Stress conditions
- Cell death :••: Hypoxia :••: Ischemia-Reperfusion; Preservation :••: Permeability transition :••: RONS; Oxidative Stress :••: Temperature
Pathological states
- Aging; senescence :••: Alzheimer's :••: Autism :••: Cancer :••: Cardiovascular :••: COPD :••: Diabetes :••: Inherited :••: Infectious :••: Muscular dystrophy :••: Neurodegenerative :••: Obesity :••: Parkinson's :••: Sepsis :••: Other
Regulation;kinetics
- Aerobic glycolysis :••: ADP :••: ATP; ADP; AMP; PCr :••: ATP :••: ATP production :••: Calcium Coupling efficiency;uncoupling :••: Cyt c :••: Flux control :••: Inhibitor :••: Ion&substrate transport :••: Ion;substrate transport :••: mt-Membrane potential :••: O2 :••: PCr;Cr :••: pH :••: Pi :••: Redox state :••: Substrate :••: Temperature :••: Threshold;excess capacity :••: Uncoupler :••: Substrate; Glucose; TCA Cycle :••: Fatty Acid :••: Amino Acid
Coupling states
- LEAK :••: ROUTINE :••: OXPHOS :••: ETS
Substrate states
- CI :••: CII :••: ETF :••: GpDH :••: CIII :••: CIV :••: CI+II :••: Other combinations :••: ROX
High-resolution respirometry - HRR
- High-resolution respirometry: Oxygraph-2k :••: TIP2k :••: Fluorometry :••: pH :••: NO :••: TPP :••: Ca :••: Spectrophotometry :••: O2k-Manual :••: Protocol :••: Theory
Additional labels
Publications in the MiPMap: mitochondrial properties in organisms (species), cell types and tissues
Initiation
- Presented at Bioblast 2012.
- Focus for MiPconference on Comparative Mitochondrial Physiology.
- MiP2013 Abstracts
- Link to Mitochondrial Global Network
