MiPMap

high-resolution terminology - matching measurements at high-resolution

MiPMap

Description

The project Mitochondrial Physiology Map (MiPMap) is initiated to provide an overview of mitochondrial properties in cell types, tissues and species. As part of Bioblast, MiPMap may be considered as an information synthase for Comparative Mitochondrial Physiology. Establishing a comprehensive database will require global input and cooperation.

A comparative database of mitochondrial physiology may provide the key for understanding the functional implications of mitochondrial diversity from mouse to man, and evaluation of altered mitochondrial respiratory control patterns in health and disease (Gnaiger 2009).

Abbreviation: MiPMap

Reference: Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837-1845.

MitoPedia methods: Respirometry, Fluorometry, Spectrophotometry 

MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., Enzyme, Media for respirometry, Inhibitor, Substrate and metabolite, Uncoupler, Permeabilization agent 

MiPMap labels

MiPMap labels provide the backbone of the MiPMap project. The MiPMap labels can be considered as keywords which can be attached to various sources of information (publications). With proper labelling, multidimensional maps of information can be constructed, filtering the sources through various grids.

The MiPMap labels (filters) are grouped into various topics (properties).

MiP areas

Property:MiP area

• Respiration :••: Instruments;methods :••: mt-Biogenesis;mt-density :••: mt-Structure;fission;fusion :••: mt-Membrane :••: mtDNA;mt-genetics :••: nDNA;cell genetics :••: Genetic knockout;overexpression :••: Comparative MiP;environmental MiP :••: Gender :••: Developmental biology :••: Exercise physiology;nutrition;life style :••: mt-Medicine :••: Patients :••: Pharmacology;toxicology :••: mt-Awareness

Mammals;models

Property:Mammal and model

• Human :••: Pig :••: Mouse :••: Rat :••: Guinea pig :••: Bovines :••: Horse :••: Dog :••: Rabbit :••: Cat :••: Other mammals :••:  :••: Chicken :••: Zebrafish :••: Drosophila :••: Artemia :••: Caenorhabditis elegans :••: Saccharomyces cerevisiae

Non-mammals

Property:Nonmammal

• Birds :••: Reptiles :••: Amphibians :••: Fishes :••: Chelicerates :••: Crustaceans :••: Hexapods :••: Myriapods :••: Annelids :••: Molluscs :••: Nematodes :••: Other invertebrates :••: :••: Fungi :••: Plants :••: Protists :••: Eubacteria :••: Archea

Tissues;cells

Property:Tissue and cell

• Heart Skeletal muscle Nervous system Liver Kidney Lung;gill Islet Cell; Pancreas; Thymus Endothelial; Epithelial; Mesothelial Cell Blood cells Fat Sex organs

Cell lines

Property:Cell line

• CHO HEK HeLa Neuroblastoma Fibroblast HUVEC Macrophage-derived Stem cells Other cell lines

Preparations

Property:Preparation

• Intact Organism Intact Organ Intact cells Permeabilized cells Permeabilized tissue Homogenate Isolated Mitochondria SMP Chloroplasts Enzyme Oxidase; Biochemical Oxidation

Enzymes

Property:Enzyme

• Adenine Nucleotide Translocase Complex I Complex II; Succinate Dehydrogenase Complex III Complex IV; Cytochrome c Oxidase Complex V; ATP Synthase Inner mtMembrane Transporter Marker Enzyme Supercomplex TCA Cycle and Matrix Dehydrogenases Uncoupling protein

Stress conditions

Property:Stress

• Cell death Hypoxia Ischemia-Reperfusion; Preservation Permeability transition RONS; Oxidative Stress Temperature

Pathological states

Property:Diseases

• Aging; senescence Alzheimer's Autism Cancer Cardiovascular COPD Diabetes Inherited Infectious Muscular dystrophy Neurodegenerative Obesity Parkinson's Sepsis Other

Regulation;kinetics

Property:Respiration and regulation

• Aerobic glycolysis ADP ATP; ADP; AMP; PCr ATP ATP production Calcium Coupling efficiency;uncoupling Cyt c Flux control Inhibitor Ion&substrate transport Ion;substrate transport mt-Membrane potential O2 PCr;Cr pH Pi Redox state Substrate Temperature Threshold;excess capacity Uncoupler Substrate; Glucose; TCA Cycle Fatty Acid Amino Acid

Coupling states

Property:Coupling states

• LEAK ROUTINE OXPHOS ETS

Substrate states

Property:Substrate states

• CI CII ETF GpDH CIII CIV CI+II Other combinations ROX High-resolution respirometry: Oxygraph-2k TIP2k Fluorometry pH NO TPP Ca Spectrophotometry O2k-Manual Protocol Theory

High-resolution respirometry - HRR

Property:Instrument and method

Additional labels

Publications in the MiPMap: mitochondrial properties in organisms (species), cell types and tissues

• O2k-Publications: Topics
• Browse publications using MiPMap filters

Initiation

• Presented at Bioblast 2012.
• Focus for MiPconference on Comparative Mitochondrial Physiology.
• MiP2013 Abstracts
• Link to Mitochondrial Global Network