Difference between revisions of "Bioblast"

Revision as of 06:14, 17 November 2011

Bioblast alert 2011(02)

O2k-Workshop IOC64 - Centre for Cellular and Molecular Biology, Hyderabad, India: 2011-12-08.

O2k-Publication: Heart failure and mitochondrial dysfunction. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism.

Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int. J. Biochem. Cell Biol. 43: 1729–1738. >>> Discussion: Complementary results on the PGC-1a pathway.

Scientific service: Tissue storage on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with SUIT protocols.

Term of the week: Uncoupled, non-coupled, dyscoupled - a hallmark of high-resolution respirometry is a matching high-resolution terminology.

Evaluate an example of low-resolution terminology: Uncoupling was studied in stressed cells by measurement of coupled respiration, evaluation of uncoupled respiration after inhibition with oligomycin, and FCCP titration to quantify uncoupled respiration.

 The Bioblast Wiki has been accessed >25,000 times (2011-11-14)

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 {{MainpageBioblast}}
-===[[Bioblast alert]]===
+===[[Bioblast alert]] 2011(02)===
-*'''[http://www.oroboros.at/index.php?ioc66 O2k-Fluorimetry Workshop IOC66]: 2012-March-15 to 16''' - an O2k-Workshop of ''[[MitoCom_K-Regio|MitoCom Tyrol]]'', Innsbruck, Austria.  The first series of the '''[[O2k-Fluorescence Module]]''' will be delivered in '''April 2012''', for orders received by end of January 2012.
+*'''[http://www.oroboros.at/index.php?id=ioc64 O2k-Workshop IOC64 - Centre for Cellular and Molecular Biology, Hyderabad, India]: 2011-12-08'''.
-*A key question on the separation of '''qualitative versus quantitative change of mitochondrial function''' is addressed in a new O2k-Publication. Does training induce mild uncoupling? Are sedentary humans healthy controls?
-::[[Pesta 2011 Am. J. Physiol. Regul. Integr. Comp. Physiol.|Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301: R1078–R1087]].
+*O2k-Publication: '''Heart failure and mitochondrial dysfunction'''. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism.
-*'''[[Scientific service]]''': [[ETS capacity]] plays a key role in such analyses, which cannot be achieved quantitatively without careful '''[[Optimum uncoupler concentration|uncoupler titrations]].
+::[[Lemieux 2011 Int. J. Biochem. Cell Biol.|Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int. J. Biochem. Cell Biol. 43: 1729–1738]]. >>> [[Talk:Lemieux 2011 Int. J. Biochem. Cell Biol.|Discussion: Complementary results on the PGC-1a pathway]].
-*'''[[Basal respiration]]''' / [[Talk:Basal respiration|'''Discussion''']] - a hallmark of high-resolution respirometry is a matching '''high-resolution terminology'''.
+*'''[[Scientific service]]''': '''[[Tissue storage]]''' on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with [[SUIT protocol]]s.
+*Term of the week: '''[[Uncoupled]], [[non-coupled]], [[dyscoupled]]''' - a hallmark of high-resolution respirometry is a matching '''high-resolution terminology'''.
+::[[Talk:Uncoupled respiration|Evaluate an example of low-resolution terminology]]: '''''[[Dyscoupled respiration|Uncoupling]]''' was studied in stressed cells by measurement of coupled respiration, evaluation of '''[[LEAK|uncoupled]]''' respiration after inhibition with oligomycin, and FCCP titration to quantify '''[[non-coupled|uncoupled]]''' respiration''.
    The Bioblast Wiki has been accessed '''>25,000 times''' (2011-11-14)