MitoEAGLE Obergurgl 2017

MitoEAGLE Obergurgl 2017

Obergurgl AT, 2017 Jul 27-30. 10^th MitoEAGLE Workshop WG1-4.

Mitochondrial Physiology Society (2017-07-27) MitoGlobal

Abstract: 2017 Jul 27-30, Obergurgl, AT.

Minutes MitoEAGLE Obergurgl 2017

- Minutes prepared by Zuzana Sumbalova.

(Attendance list)

Find the WG summaries in the Minutes and also below

Programme MitoEAGLE Working Groups Workshop

- - - 2017-07-27

Arrival MitoEAGLE workshop

- - - 2017-07-28 to 29

MitoEAGLE Workshop: WG1-4

WG1: Harmonization of nomenclature on mitochondrial respiratory states and control parameters: Status of the consensus paper on a consistent terminology on mitochondrial physiology and bioenergetics; recommendations for the use of a common terminology in mitochondrial physiological research as a milestone towards unification of concepts and nomenclature.

» The protonmotive force and respiratory control: Building blocks of mitochondrial physiology - Manuscript in preparation by the MitoEAGLE Terminology Group.

» Add critical discussion on 'ATP production' (not to be confused with a difference of respiratory fluxes), 'glycolytic flux' (not to be confused with extracellular proton flux), 'reserve capacity' (is the difference of ET capacity and ROUTINE respiratory activity a 'reserve'?), confusion of ET capacity ('State 3u') and OXPHOS capacity, ..

WG1: Respirometric reference protocols:

Standard format for presenting substrate-uncoupler-inhibitor titration (SUIT) protocols for a ‘library of protocols’ applied in mitochondrial respiratory physiology.
Criteria for selecting and recommending reference protocols.
Documentation of the state-of-the-art standards in designing, conducting, reporting, interpreting, and validating SUIT protocols.
Compare: Maelstrom Research program- data repository and harmonization.

WG2-4: Data repositories

Summary of WG2: steps towards database: Summary from Obergurgl, 2017.
Summary of WG4 cell lines: WG4 Cell Lines Obergurgl, 2017.
Summary of WG4 blood cells:WG4 Blood cells Obergurgl, 2017

- - - 2017-07-30

Departure MitoEAGLE

MitoEAGLE Working Groups Workshop 2017 Programme: Abstracts in sequential sessions

Friday and Saturday, Jul 28 and 29, 09:00-12:00 16:00-19:00 »Help - Further information - Make full use of the MiPMap

	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Krajcova 2017 MITOEAGLE Obergurgl	Developing a method of assessing mitochondrial functions in homogenates of human heart muscle.	Respiration Pharmacology;toxicology	Human			Cardiovascular
Chabi 2017 MITOEAGLE Obergurgl	Optimization of permeabilized fibers preparation for mitochondrial respiration measurements using Design of Experiments methodology.	Respiration	Mouse	Skeletal muscle
Pavlovic 2017 MITOEAGLE Obergurgl	Establishing cellular model for studying mechanisms of muscle insulin resistance: towards understanding the role of mitochondria.	Respiration mt-Medicine mt-Awareness	Mouse	Skeletal muscle		Diabetes
Gainutdinov 2017 MITOEAGLE Obergurgl	Different ways of reactive oxygen species (ROS) formation by brain mitochondria.	Respiration	Mouse Rat	Nervous system	Oxidative stress;RONS
Ukropec 2017 MITOEAGLE Obergurgl	Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?	Respiration Exercise physiology;nutrition;life style		Skeletal muscle		Aging;senescence Diabetes Neurodegenerative
Bento 2017 MITOEAGLE Obergurgl	Isolation of human urine-derived stem cells for mitochondrial function profile assessment.	Respiration	Human	Stem cells
Ferreira 2017 MITOEAGLE Obergurgl	Doxorubicin toxicity and mitochondrial dysfunction in mouse induced pluripotent stem cells-derived cardiomyocytes.	Pharmacology;toxicology Respiration	Mouse	Heart Stem cells
Waldauf 2017 MITOEAGLE Obergurgl	Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.	Respiration Pharmacology;toxicology	Human	Skeletal muscle
Garcia-Roves 2017 MITOEAGLE Obergurgl	MitoEAGLE data repository on muscle tissues - current status.
Muntane 2017 MITOEAGLE Obergurgl	Integration of oxidative and nitrosative stress in the overall cell death signaling induced by Sorafenib in hepatoma cells.	Pharmacology;toxicology	Human	Liver	Cell death Oxidative stress;RONS	Cancer
Dubouchaud 2017 MITOEAGLE Obergurgl	Effects of a single bout of exercise on the production of reactive oxygen species in muscle and liver isolated mitochondria.	Exercise physiology;nutrition;life style Respiration	Rat	Skeletal muscle Liver	Oxidative stress;RONS
Crisostomo 2017 MITOEAGLE Obergurgl	Glycerol metabolism in testicular cells – a mitochondrial tale that may control male reproductive potential.		Human	Genital
Iglesias-Gonzalez 2017 MITOEAGLE Obergurgl	Javier Iglesias-Gonzalez Oscillations in mitochondrial ROS production as a new mechanism for cell cycle control.	Respiration mt-Medicine			Oxidative stress;RONS
Scatena 2017 MITOEAGLE Obergurgl	Cancer stem cell differentiation induced by PPAR ligands. Which role for an inhibition of mitochondrial respiratory chain?	Pharmacology;toxicology	Human	Liver		Cancer

Support

This project has received funding from the European Union's Horizon 2020 research and innovation programme supported by COST (European Cooperation in Science and Technology) under grant agreement No OC-2015-2-19984.

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2017, ORO, MitoFit, MitoEAGLE, MitoGlobal