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• S-pathway control state
  31 bytes (3 words) - 15:46, 3 June 2020

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• NS e-input
  ...of substrates for the [[N-pathway control state]] and [[S-pathway control state]] through Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction
  1 KB (149 words) - 18:49, 1 January 2021
• O2k-Publications: S
  [[File:SUIT-catg FNSGp.jpg|right|200px|link=Electron-transfer-pathway state|Electron-transfer-pathway states]] ::::» MitoPedia: '''[[S-pathway control state]]'''
  1 KB (190 words) - 10:02, 3 June 2020
• Pathway control ratio
  ...OS]], [[Electron transfer pathway]]), numerous [[Electron-transfer-pathway state]]s are possible. ...h variable [[N]]-linked injuries are studied. In contrast, the [[reference state]], ''Z'', is strictly defined for [[flux control efficiency]].
  1 KB (206 words) - 12:20, 25 November 2020
• NS-S pathway control efficiency
  ..., S(Rot) or S. Then the NS-S pathway control efficiency in the ET-coupling state is ...pe N substrate combination. Experimentally rotenone Rot is added to the NS-state. The reversed protocol, adding N-substrates to a S-pathway control backgrou
  2 KB (288 words) - 18:30, 1 January 2021
• SUIT-003 Ce1;ce2SD;ce3U;ce4Rot;ce5Ama
  ! Respiratory state ...f respiration. Mitochondria of dead cells (dce) without substrate are in a state of ROX.
  1 KB (216 words) - 09:44, 3 June 2020
• Hyphenation
  ...nt), but if the compound adjective follows the term (measurement at steady state), hyphenation does not add any information and should be avoided. Find more ...ate]] (''NOT'' 'Coupling control state' - it is not 'coupling of a control state')
  4 KB (469 words) - 02:31, 23 January 2023
• NADH electron transfer-pathway state
  ...alonic acid]]). In the N-pathway control state [[Electron-transfer-pathway state|ET pathway level 4]] is active. |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]]
  3 KB (409 words) - 08:06, 25 November 2023
• Pathway and coupling control states
  ...nd ''E'' as subscripts attached to the abbreviation of the pathway control state. ::::* [[N-pathway control state]] N_''L'', N_''P'', N_''E''
  2 KB (340 words) - 16:40, 6 July 2023
• Complex II-linked substrate state
  |description=''See'' '''[[S-pathway control state]] (previous: CII-linked) |mitopedia concept=Respiratory state, SUIT state, Find
  227 bytes (26 words) - 07:06, 29 May 2018
• NS-pathway control state
  ...rations by addition of [[NADH]]-generating substrates ([[N-pathway control state]] in combination with [[succinate]] ([[Succinate pathway]]; S). Whereas NS |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Bio
  4 KB (604 words) - 08:32, 25 November 2023
• FNS
  ...ed pathway control) in combination with [[succinate]] ([[S-pathway control state]]; S- or CII-linked) and one or several fatty acids, which are supplied to |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]]
  3 KB (403 words) - 19:58, 1 January 2021
• SUIT-003 Ce1;ce1SD;ce2Omy;ce3U-
  ! Respiratory state | Dead cells (dce) without substrate are in a state of ROX.
  2 KB (325 words) - 12:35, 25 November 2020
• SUIT-003 Ce1;ce2SD;ce3Omy;ce4U-
  ! Respiratory state | Dead cells (dce) without substrate are in a state of ROX.
  2 KB (325 words) - 12:33, 25 November 2020
• Cardoso 2022 Q10 Hamburg
  |title=Cardoso LHD, Donnelly C, Komlodi T, Gnaiger E (2022) Coenzyme Q redox state and respiration in permeabilized HEK 293T cells: coupling and pathway contr ...rial inner membrane. ET capacity is measured in the noncoupled respiratory state after application of uncouplers, whereas LEAK respiration is assessed in th
  4 KB (580 words) - 18:34, 5 May 2022
• Q-junction
  ...upstream, provides the rationale for defining [[Electron-transfer-pathway state]]s and [[categories of SUIT protocols]].
  2 KB (291 words) - 19:31, 25 August 2023
• SUIT-020 O2 mt D032
  ...f the ATP synthase. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t ...tate| S]] and [[NADH Electron transfer-pathway state| N-]] pathway control state.
  4 KB (636 words) - 15:11, 17 September 2020
• N/S pathway control ratio
  ...s. The S-pathway control state may be selected preferentially as reference state, if mitochondria are studied with respect to N-pathway injuries. ...in the OXPHOS-state, but N_''E''/S_''E'' ~ 2 in the ET-state (high [[E-P excess capacity |''E-P'' excess capacity]] specifically for the
  2 KB (300 words) - 19:14, 30 December 2020
• Categories of SUIT protocols
  ...of substrates and inhibitors which define the [[Electron-transfer-pathway state]]s. The [[N-pathway control |N-type substrates]] are listed in parentheses, ...Y(X)'''- In the SUIT general protocols Y makes reference to the ET-pathway state and X to the combination os substrates added for the corresponding pathway.
  5 KB (673 words) - 16:25, 3 June 2020
• Sharma 2015 Proc Natl Acad Sci U S A
  ...ns, we propose that this short-circuit is effectively prevented by a redox-state-dependent organization of water molecules within the protein structure that
  2 KB (284 words) - 20:06, 27 January 2024
• Komlodi 2017 MiPschool Obergurgl
  ...b> production in the LEAK state and O₂ consumption in the OXHOS state establishes the concept that electron pressure generated by the linear S- a |topics=Flux control, Inhibitor, Q-junction effect, Redox state, Substrate
  5 KB (694 words) - 18:54, 10 January 2022
• Kaila 2014 Proc Natl Acad Sci U S A
  ...we constructed a symmetry-related structure of a possible alternate-access state. In molecular dynamics simulations, we find the resulting structural change
  2 KB (327 words) - 19:56, 27 January 2024
• S/NS pathway control ratio
  ...ing N-type substrates to a [[S-pathway control state]] as the [[background state]] does not provide a valid estimation of S-linked respiration with succinat
  1 KB (163 words) - 18:28, 1 January 2021
• Vartak 2013 Protein Cell
  ...iffused in the inner mitochondrial membrane has been replaced by the solid state supercomplex model wherein the respiratory complexes associate with each ot
  2 KB (218 words) - 16:01, 5 November 2023
• SUIT protocol names
  ...y listing in parentheses the substrates applied in the [[N-pathway control state]]s, again independent of the sequence of titrations, e.g. NS(GM), NS(PM), F ...mma). The [[Marks in DatLab |Marks]] define the section of a [[respiratory state]] in the SUIT protocol. The [[Mark names in DatLab |Mark name]] contains th
  2 KB (267 words) - 09:59, 3 June 2020
• SUIT-031
  ...are designed to measure simultaneously O₂ flux and the Q-redox state in isolated mitochondria and permeabilized cells. ...t D072]] simultaneous determination of O₂ flux and the Q-redox state in isolated mitochondria and cells permeabilized previously to addition to
  4 KB (623 words) - 17:57, 13 December 2023
• SUIT-039 O2 mt D092
  ...er electron transfer pathways are also analyzed in OXPHOS (FN, FNS) and ET-state (FNS, S). :::+ The protocol provides information on F-pathway in OXPHOS state with palmitoylcarnitine, a long-chain acylcarnitine commonly found ''in viv
  3 KB (387 words) - 11:21, 14 April 2023
• SUIT-039 O2 pfi D093
  ...er electron transfer pathways are also analyzed in OXPHOS (FN, FNS) and ET-state (FNS, S). :::+ The protocol provides information on F-pathway in OXPHOS state with palmitoylcarnitine, a long-chain acylcarnitine commonly found ''in viv
  3 KB (387 words) - 12:30, 14 April 2023
• PGMS-pathway control state
  '''MitoPathway control state:''' [[NS|NS-pathway control state]] ::::» [[NS-pathway control state]]
  2 KB (284 words) - 18:29, 17 March 2022
• Schinagl 2016 PLoS One
  ...r W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus ''Penicillium ochrochloron'': method dev ...lium and a direct transfer of a broth sample into the respirometer. Steady state respiration was 29% below its maximum respiratory capacity. Additionally to
  3 KB (386 words) - 15:46, 14 October 2023
• Cardoso 2022a EBEC
  ...of the Q-junction, respectively, impacts the relation between the Q redox state and O₂ flux in opposite directions. Therefore, our aim was to ch ...he NextGen-O2k with Q-Module to measure O₂ flux and the Q redox state simultaneously, using CoQ₂ as a probe [3]. Cryopreserved HEK 293
  4 KB (519 words) - 14:25, 23 August 2022
• SUIT-021 O2 mt D035
  ...tate| S]] and [[NADH Electron transfer-pathway state| N-]] pathway control state. ...s to be determined. Higher concentrations of oligomycin may inhibit the ET state.
  3 KB (420 words) - 09:20, 18 September 2020
• Komlodi 2018 AussieMit
  ...O₂ flux, H₂O₂ flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU. ...an altered Q redox state. We analyzed the relationship between the Q redox state, H₂O₂ and O₂ fluxes with fuel substrates p
  3 KB (517 words) - 18:56, 10 January 2022
• Verkhovsky 1996 Nature
  ...coli leads to a corresponding decrease in the enzyme's operational steady-state affinity for O2. This demonstrates directly that fast electron transfer bet
  2 KB (247 words) - 21:39, 24 September 2021
• Komlodi 2021 MitoFit Q
  ...Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/mitofit: ...omlodi_2021_MitoFit_Q.pdf Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria]
  5 KB (767 words) - 08:41, 8 January 2023
• Cardoso 2022 ESCI Bari
  ...getic fingerprinting with coupling and pathway control of coenzyme Q redox state and respiration in permeabilized HEK 293T cells. 56^th Annual Sci We characterised the Q redox state in pathway and coupling control using the Oroboros NextGen-O2k with the ele
  4 KB (520 words) - 14:41, 30 May 2022
• SUIT-028
  ! Respiratory state ...ate with type N substrates, N_''L'': Non-phosphorylating resting state with NADH-linked (type N) substrates pyruvate&glutamate&malate (PGM; withou
  4 KB (574 words) - 16:13, 14 April 2020
• SUIT-021
  ...support NADH-linked respiration. Oligomycin (Omy) is used to induce a LEAK state of respiration via the inhibition of the ATP synthase. Since higher concent ...sed [[Mitochondrial membrane potential|mt-membrane potential]] in the LEAK state.
  5 KB (697 words) - 15:58, 8 June 2020
• Succinate pathway
  ...that supports succinate-linked respiration (succinate-induced respiratory state; previously used nomenclature: CII-linked respiration; SRot; see [[Gnaiger The S-pathway control state is usually induced in mt-preparations by addition of succinate&rotenone. In
  8 KB (1,053 words) - 08:04, 30 March 2023
• Electron-transfer-pathway state
  |abbr=''ET-pathway state'' ...state]]s. [[Coupling-control state]]s require [[Electron-transfer-pathway state|ET-pathway competent states]], including oxygen supply. [[Categories of SUI
  15 KB (1,913 words) - 19:27, 25 August 2023
• SUIT-020
  ...f the ATP synthase. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t ...sed [[Mitochondrial membrane potential|mt-membrane potential]] in the LEAK state.
  5 KB (756 words) - 15:03, 17 September 2020
• SUIT-021 Fluo mt D036
  ...f the ATP synthase. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t ...sed [[Mitochondrial membrane potential|mt-membrane potential]] in the LEAK state.
  6 KB (834 words) - 14:07, 6 September 2021
• State 3
  ...ate]] of respiration, whereas the cytochromes are in a more oxidized redox state. |mitopedia concept=Respiratory state, Find
  3 KB (449 words) - 18:46, 1 January 2021
• Chicco 2022 Abstract Bioblast
  ...(NS > S). However, in some types of mitochondria, rotenone added in the NS-state elicits a paradoxical increase in ''J''_O₂, revealing ::::# Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA - [email protected]
  4 KB (625 words) - 08:33, 28 July 2022
• SUIT-004
  ...y_state|N]], [[NS-pathway control state| NS]], [[Succinate pathway control state| S]]). SUIT-004 can be extended with the CIV assay module. ...n| ''P'']]-[[ET capacity| ''E'']]) with N substrates ([[PM-pathway control state|PM]]).
  2 KB (293 words) - 23:36, 12 April 2021
• SUIT-009 AmR mt D021
  ...in the LEAK state. Pyruvate (P) supports [[NADH Electron transfer-pathway state|NADH-pathway (N)]], and usually in the presence of ADP it does not increase ...s protocol is designed to evaluate RET in the S-linked pathway in the LEAK state, which is decreased by ADP due to reduction of the mt-membrane potential.
  5 KB (681 words) - 00:11, 13 April 2021
• Komlodi 2022 Q10 Hamburg
  ...s: Continuous monitoring of pull and push control of respiration and redox state of the Q-mimetic CoQ₂. Q10 Hamburg. ...mplemented into the Oroboros NextGen-O2k to monitor continuously the redox state of CoQ2 added as a Q-mimetic simultaneously with O2 consumption (Komlódi e
  4 KB (559 words) - 18:39, 5 May 2022
• SUIT-012 O2 mt D027
  ...without the involvement of the [[complex II]] ([[Succinate pathway control state| S-pathway]]). It can be useful to understand the contribution and the acti ...pathway state| N-pathway]] is lower and of the [[Succinate pathway control state| S-pathway]] is higher with GM compared to PM (GMP is inhibited by the CII
  3 KB (397 words) - 00:12, 13 April 2021
• Bioblast alert 2016
  Let's face it: even the state-of-the-art terminology and the many inconsistent variations are not commonl An even worse mistake: we say ‘[[Complex I&II-linked substrate state |CI<small>&</small>II]]’ (or a previous mistake: ‘CI+II’: ''are the t
  4 KB (529 words) - 09:59, 3 June 2020
• Mathiyazakan 2023 Antimicrob Agents Chemother
  ...nterpart of the soluble mitochondrial cytochrome c, in a so-called "closed state," in which electrons are translocated from the bcc to the aa3 domain. The s
  2 KB (335 words) - 18:10, 17 September 2023
• N/NS pathway control ratio
  ...TS competent N-linked substrate combinations) and the [[NS-pathway control state]] (N in combination with succinate). NS indicates respiration with a cockta = List of publications: N and NS pathway control state =
  1 KB (163 words) - 18:27, 1 January 2021
• SUIT-012
  ...-[[ET capacity| ''E'']]) with NADH-linked substrates ([[PM-pathway control state|PM]] and PGM)''' ...may be relevant in the presence of [[glutamate-anaplerotic pathway control state]]. SUIT-012 can be extended with the CIV assay module.
  4 KB (505 words) - 23:57, 12 April 2021
• Chance 1961 J Biol Chem-I
  ...n level of pyridine nucleotide than was observed aerobically in state 4. These observations suggest that the presence of adenosine 5’
  3 KB (323 words) - 12:06, 8 November 2016
• Komlodi 2021 BEC Q
  ...Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioenerg Commun 2021.3. https://d ...same manner as Q at Complexes CI, CII and CIII. The CoQ₂ redox state is monitored amperometrically with the working electrode, which is poised a
  6 KB (810 words) - 16:37, 21 January 2024
• Komlodi 2018 EBEC2018
  ...f mitochondrial respiration, H₂O₂ flux and the redox state of the Q-pool. ...Q-pool [1]. We aimed at investigating the relationship between the Q redox state, H₂O₂ and O₂ fluxes with various fuel subs
  4 KB (592 words) - 19:02, 10 January 2022
• SUIT-024 O2 ce-pce D056
  ...combinations for N-pathway control state; S or RotS for S-pathway control state.
  2 KB (276 words) - 12:36, 25 November 2020
• Van den Bergen 1994 Eur J Biochem
  ...ty of the cyanide-resistant pathway. The relation between rate and Q redox state for the external NADH dehydrogenase in potato callus mitochondria was found ...spiration rate is proportional to the redox state of the Q-pool. - ''redox state expressed as QH₂ fraction''
  7 KB (1,023 words) - 09:03, 16 July 2021
• GMS-pathway control state
  ::::» [[OctPGMSGp pathway control state]] ::::» [[NS-pathway control state]]
  3 KB (378 words) - 18:30, 17 March 2022
• Cardoso 2022 Abstract Bioblast
  ...nitoring of respiration together with NAD(P)H autofluorescence and Q-redox state [1] provides unique analytical and diagnostic power in the study of mitocho ...Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/bec:2021
  3 KB (463 words) - 08:34, 28 July 2022
• Liang 2019 Front Microbiol
  ...ectron transfer. Further, the short-lived anionic flavin semiquinone (ASQ) state of b-FAD is essential for electron bifurcation. Nfn homologs are widely dis
  3 KB (404 words) - 00:04, 5 November 2023
• Additive effect of convergent electron flow
  ...espiratory capacities, N + S, is identical to the capacity measured in the state with combined substrates, NS (CI<small>&</small>II). This condition of comp
  3 KB (428 words) - 15:34, 31 January 2024
• SUIT-027
  |abbr= [[Malate-anaplerotic pathway control state|Malate anaplerosis]] |info='''A:''' '''[[Malate-anaplerotic pathway control state|Malate anaplerotic pathway]]'''
  3 KB (429 words) - 12:04, 3 June 2020
• Gnaiger 1998 J Exp Biol
  ...is necessary to prevent a large decrease in oxygen affinity in the active state. Upregulation of oxygen affinity provides a functional explanation of the e ...t from definitions by Chance, Williams 1955) has the meaning of a [[LEAK]] state of respiration, without added adenylates (no ADP and no ATP) in the presenc
  4 KB (588 words) - 16:42, 24 April 2023
• Briston 2017 Sci Rep
  ...herapies. Here, we have investigated the impact of mitochondrial metabolic state on the probability and consequences of mPTP opening. Isolated mitochondria
  2 KB (324 words) - 12:54, 10 March 2020
• Szibor 2019 Biochim Biophys Acta Bioenerg
  ...reduces the Q pool almost entirely (>90 %) irrespective of the respiratory state. AOX enhances the forward electron transfer (FET) from CII thereby decreasi |topics=Redox state, Q-junction effect
  3 KB (458 words) - 12:35, 3 April 2021
• SUIT-009 AmR ce-pce D019
  ...s dramatically. Pyruvate (P) supports the [[NADH Electron transfer-pathway state|NADH-pathway]] and thus the convergent NS-pathway with little further effec ...s protocol is designed to evaluate RET in the S-linked pathway in the LEAK state, which is decreased by ADP due to reduction of the protonmotive force, ''pm
  5 KB (832 words) - 00:10, 13 April 2021
• SUIT-006
  ...tate appropriately. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t ...tential measurements, choose [[SUIT-006 Fluo mt D034]]. For O2 and Q redox state measurements, choose [[SUIT-006 Q mt D071]] or [[SUIT-006 Q ce-pce D073]].
  8 KB (1,169 words) - 13:08, 13 December 2023
• Gnaiger 2009 Int J Biochem Cell Biol
  ...te in the matrix as substrates for NS-pathway control. This physiological state is reconsituted in mitochondrial preparations by external NS-substrate supp :::::* MitoPedia:» [[Electron-transfer-pathway state#Terminology: from CI- and CII-linked to N and S]]
  7 KB (975 words) - 13:46, 1 May 2024
• Q-pools
  ...lision model) and Q tightly bound to supercomplexes according to the solid-state model. The two models describe the extremes in a continuum of homogenous or ..._hom || homogenous pool of ETS-reactive Q according to the fluid-state model (random-collision model) || || 1, 4, 5
  5 KB (698 words) - 21:19, 3 April 2021
• SUIT-024
  ...hich leads to an overestimation of LEAK respiration, when comparing [[LEAK state without adenylates|''L''(n)]] and [[LEAK respiration|''L''(Omy)]]. Tissue h ...ther N-pathway substrate combinations; S or RotS for the S-pathway control state.
  3 KB (400 words) - 12:36, 25 November 2020
• Fato 2009 Biochim Biophys Acta
  ...iacetate. ROS production by Complex I is strictly related to its inhibited state. Our results indicate that different Complex I inhibitors can be grouped in
  2 KB (325 words) - 13:22, 30 November 2018
• Donnelly 2024 Redox Biol
  ...n isolated mitochondria, myotubes and exercising humans. Performing steady-state respirometry with isolated mitochondria we found that oxygen limitation of |topics=Calcium, mt-Membrane potential, Oxygen kinetics, Redox state
  3 KB (366 words) - 13:55, 1 May 2024
• Muller 2008 Biochem J
  ...ations of succinate and is thought not to occur when NAD is in the reduced state. However, very few studies have examined the rates of superoxide production
  3 KB (401 words) - 17:48, 16 January 2021
• Cogliati 2021 Biochem Soc Trans
  ...explore how they modulate the ETC organization according to the metabolic state. Since the field is rapidly growing, we also comment on the experimental te
  2 KB (269 words) - 16:55, 8 October 2023
• SUIT-003 O2 ce D061
  ...the SUIT-003 O2 ce D061 protocol allows evaluating the [[coupling control state |coupling control]] of living cells. Respiratory capacities are tested in a
  4 KB (515 words) - 12:36, 25 November 2020
• SUIT-009
  ...n in the LEAK state. Pyruvate (P) promotes[[NADH Electron transfer-pathway state|NADH-pathway (N)]], and usually in the presence of ADP, H₂O<sub ...ub>2</sub>O₂ flux on the mt-membrane potantial on the N-control state in isolated mitochondria, tissue homogenate and permeabilized cells (alread
  6 KB (864 words) - 23:56, 12 April 2021
• Donnelly 2024 EU-METAHEART MC2 Meeting
  ...ects on oxidative phosphorylation, mitochondrial membrane potential, redox state of coenzyme Q, and calcium uptake. EU-METAHEART MC2 Meeting 2024 Antalya TR ...₂ levels in studies of isolated mitochondria. Performing steady-state respirometry with isolated mouse cardiac mitochondria [2] we found that oxy
  2 KB (328 words) - 15:53, 13 March 2024
• SUIT-020 Fluo mt D033
  ...sed [[Mitochondrial membrane potential|mt-membrane potential]] in the LEAK state. ...tate| S]] and [[NADH Electron transfer-pathway state| N-]] pathway control state.
  5 KB (655 words) - 08:41, 30 September 2020
• Oliveira Pinto 2013 Abstract IOC75
  |topics=Aerobic glycolysis, Redox state
  3 KB (359 words) - 15:14, 20 October 2017
• SUIT-025
  ...ion_pathway_control_state|F]], F(N), [[FN]] and [[FNS]] pathways in OXPHOS state can be evaluated by using this SUIT protocol. :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d
  3 KB (407 words) - 13:24, 5 June 2019
• Sharpley 2006 J Biol Chem
  ...n2+ inhibition of complex I is high (10-50 microm, depending on the enzyme state); therefore, complex I is unlikely to be a major site for zinc inhibition o
  2 KB (327 words) - 04:53, 15 October 2023
• Pichaud 2012 Comp Biochem Physiol A Mol Integr Physiol
  ...em, and suggested that the AOX activity is triggered not only by the redox state of the cell but also by the type of substrates provided to mitochondria.
  2 KB (280 words) - 11:04, 23 June 2022
• Vesga 2021 Med Chem Res
  ...en consumption in the LEAK state (10 µM, 24 h), as well as the increase in state 4 in the mitochondrial bioenergetics. In all cases, molecular hybrids incre
  2 KB (273 words) - 09:31, 9 November 2023
• Doerrier 2017 MiPschool C2
  ...ol and the subsequent linear sequence of pathway control in the ET-pathway state. RP2) RP2 has a focus on OXPHOS capacity of fatty acid oxidation (F-pathway
  5 KB (706 words) - 12:00, 27 May 2019
• Sharma 2013 Proc Natl Acad Sci U S A
  ...V, Karlin KD, Wikström M (2013) Computational study of the activated O(H) state in the catalytic mechanism of cytochrome ''c'' oxidase. Proc Natl Acad Sci ...theory calculations, to be substantially higher in the O(H) state than in state O. Our calculations also suggest that the neutral radical form of the cross
  2 KB (331 words) - 19:46, 27 January 2024
• Templage:Keywords-MitoPedia BEC 2020.2
  ...b>2</sub></sub> || 1 || P»/O₂ ratio measured in any respiratory state; Section 1.6; Eq. 3.4 | coupling control state || [[Coupling control state]] || CCS || - || Section 2.4.1
  15 KB (2,142 words) - 23:29, 6 February 2021
• SUIT-019
  ...rylation|OXPHOS state]], and [[FN]]—[[FNS]]—[[S]] in the [[ET capacity| ET state]]. ...he protocol provides information on [[Fatty acid oxidation pathway control state| F-pathway]] (in presence of palmitoylcarnitine, and palmitoylcarnitine&oct
  3 KB (412 words) - 12:33, 25 November 2020
• Sjoevall 2010 Crit Care
  ...n septic plasma exhibited increased basal non-phosphorylating respiration (state 4) compared to controls and to platelets suspended in PBS glucose. In paral
  3 KB (486 words) - 13:22, 27 December 2021
• ET capacity
  ...e addition of defined fuel substrates to establish an ET-pathway competent state. » [[#Why ET capacity, why not State 3u.3F | '''MiPNet article''']]
  11 KB (1,488 words) - 20:30, 19 March 2022
• Gnaiger 2018 MiPschool Tromso A1
  ...s]]. Complementary to [[pathway control state]]s (PCS), [[coupling control state]]s (CCS: ET, OXPHOS, LEAK) are defined in mt-preparations, and the correspo ...basis, the classical [[respiratory acceptor control ratio]] (RCR = State 3/State 4 respiration) has to be replaced by the biochemical coupling efficiency, d
  10 KB (1,441 words) - 23:46, 25 January 2021
• Jensen 2007 Biochimica et Biophys Acta (BBA) - Bioenergetics
  ...y transfer, Light harvesting, Photosynthesis, Red chlorophylls Regulation, State transitions
  2 KB (311 words) - 17:53, 4 March 2020
• Hoppel 2021 Front Physiol
  .... There were inverse correlations between race time and N-linked substrate state PRE-POST, and changes in CK and LDH levels were significantly related to PL
  4 KB (517 words) - 15:51, 7 June 2022
• Duicu 2012 Rev Med Chir Soc Med Nat Iasi
  ...ansport system (ET-pathway); CII_P, 302.26 +/- 50.16 (CII dependent OXPHOS state obtained after the addition of a CI inhibitor rotenone, with the subsequent
  2 KB (325 words) - 11:42, 23 January 2019
• Jumbo-Lucioni 2012 BMC Genomics
  ...3 SNPs can explain 31, 13, and 18% of the phenotypic variation in state 3, state 4, and P:O ratio, respectively. Most of the genes tagged by the SNPs are in
  3 KB (412 words) - 12:21, 9 August 2019
• Malate
  ...te| FAO-pathway]]. In the presence of [[Malate-anaplerotic pathway control state|anaplerotic pathways]] (''e.g.'', [[Malic enzyme|mitochondrial malic enzyme
  4 KB (585 words) - 19:57, 5 February 2022
• SUIT-037 O2 mt D090
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Pal-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  3 KB (485 words) - 11:21, 14 April 2023
• SUIT-011
  ...y capacity ([[Oxidative phosphorylation|OXPHOS]] with [[NS-pathway control state|NS substrates]]) and coupling/pathway control''' ...ET state ([[NS-pathway control state|NS]] and [[Succinate pathway control state|S]]). SUIT-011 can be extended with the CIV assay module.
  6 KB (951 words) - 15:35, 8 June 2020
• Doerrier 2017 Abstract MitoEAGLE Barcelona
  ...ol and the subsequent linear sequence of pathway control in the ET-pathway state. RP2) RP2 has a focus on OXPHOS capacity of fatty acid oxidation (F-pathway
  6 KB (754 words) - 12:00, 27 May 2019
• Wessels 2019 Obesity (Silver Spring)
  |abstract=The study aimed to investigate how obesity and glycemic state affect mitochondrial respiration and ATP-generating pathways in mature huma ...In both depots, the respiratory capacity was not affected by the glycemic state. A positive correlation between BMI and adipocyte lactate release was measu
  2 KB (295 words) - 14:51, 15 May 2019
• Ojuka 2015 Abstract MiPschool Cape Town 2015
  carnitine or malate increase State 2 respiration (oxygen consumption
  3 KB (438 words) - 16:16, 26 March 2018
• SUIT-025 O2 mt D057
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  2 KB (345 words) - 10:29, 18 September 2020
• Jarmuszkiewicz 2023 Front Biosci (Landmark Ed)
  ...uction. We have proposed that the level of reduction (the endogenous redox state) of mtQ may be a useful indirect marker to assess total mtROS formation. A ...ctrode [28,129] will contribute to the widespread measurement of the redox state of mtQ in isolated respiring mitochondria."
  3 KB (422 words) - 11:58, 27 March 2023
• Pichaud 2013 Abstract MiP2013
  |topics=ADP, Flux control, Inhibitor, Oxygen kinetics, Redox state, Substrate, Temperature, Uncoupler
  2 KB (323 words) - 15:39, 13 November 2017
• Flux control efficiency
  ...h (stimulated or un-inhibited) flux; ''Y_X'' is the [[background state]] at low flux, upon which ''X'' acts. ...x from ''Y_X'' to ''Z_X'' normalized for the reference state ''Z_X''.
  8 KB (1,272 words) - 18:27, 1 January 2021
• SUIT-006 O2 mt D022
  ...''see'' [[MitoPedia: Sample preparations]]) at [[Succinate pathway control state]].
  3 KB (368 words) - 23:53, 12 April 2021
• Lemieux 2011 Abstract Bordeaux
  ...lation. Under these conditions, the increase of respiration in the OXPHOS state at constant ET capacity indicates a mitochondrial dysfunction after cold pr ...ux control ratios by internal normalization for oxygen flux in a reference state [2].
  6 KB (874 words) - 18:21, 10 January 2022
• Du 2016 Aquat Toxicol
  ...mplies a heritable change in OxPhos function. The observation that LEAK, E-State, Complex I and Complex II were different in laboratory bred versus field-ca
  3 KB (402 words) - 17:52, 9 November 2017
• Selivanov 2011 PLoS Comput Biol
  ...lex III, remains valid for the whole RC. The conditions for switching to a state with a high content of free radicals in Complex III were predicted based on |topics=mt-Membrane potential, Redox state
  3 KB (364 words) - 17:59, 29 February 2020
• SUIT-036 O2 mt D089
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Pal-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  3 KB (450 words) - 11:20, 14 April 2023
• SUIT protocol library
  ...Define pathway states |Define substrates and inhibitors]] for each pathway state. ...pathway control state]], [[S-pathway control state]], [[NS-pathway control state]]). Titrations may performed in a single step, or in multiple steps for seq
  5 KB (721 words) - 15:01, 8 June 2020
• Gnaiger Abstract MiP2010 2-01
  ...ondrial respiratory capacity of fibroblasts in vivo. The coupled reference state and reinterpretation of the uncoupling control ratio. Mitochondr Physiol Ne
  8 KB (1,121 words) - 19:16, 10 January 2022
• Gnaiger 2017 Abstract MitoEAGLE Barcelona
  ...ADH&succinate (NS) pathway, and azide titrations in the NS-pathway control state or single step of CIV. As&TM, Ascorbate&TMPD. From Ref [8].
  7 KB (927 words) - 18:53, 10 January 2022
• SUIT-031 O2 mt D075
  |info='''A''' to analyse O₂ flux in the NS- pathway control state on isolated mitochondria- '''[[SUIT-031]]''' ...n the N-pathway and contribution of G-, S-, Oct- and Gp-pathways in the ET state for isolated mitochondria, tissue homogenate and cells permeabilized before
  3 KB (355 words) - 11:56, 2 December 2021
• Muller 2013 Exp Neurol
  ...maximum level of ∆Ψm induced by succinate in synaptosomes in a depolarized state. Similarly, insulin decreased ROS production in neuronal cultures. In mitoc
  3 KB (378 words) - 17:05, 27 March 2018
• SUIT-029 O2 mt D066
  :::::::+ Evaluation of ET-state with NADH-linked substrates allows to calculate ET-coupling efficiency (1-' ...ditive effect of convergent flux through NADH-linked respiration in the ET-state is evaluated (5G).
  4 KB (508 words) - 11:50, 15 March 2024
• Goetz 2000 J Neural Transm (Vienna)
  ...R, Dirr A, Janetzky B, Kuhn W, Riederer P, Gerlach M (2000) Altered redox state of platelet coenzyme Q₁₀ in Parkinson's disease. J Neural Transm ...transport which might be reflected by the platelet CoQQ₁₀ redox state.
  2 KB (364 words) - 12:39, 3 April 2021
• SUIT-031 O2 ce-pce D079
  |info='''A''' to analyse O₂ flux in the NS- pathway control state in permeabilized cells- '''[[SUIT-031]]''' ...n the N-pathway and contribution of G-, S-, Oct- and Gp-pathways in the ET state for isolated mitochondria, tissue homogenate and cells permeabilized before
  3 KB (361 words) - 12:15, 2 December 2021
• Wollenman 2017 PLOS ONE
  ...f 16%, 26%, and 35% for the leak state, ADP-simulated state, and uncoupled state, respectively, relative to rates using B1. The common feature distinguishin ...way control state |Pyruvate&malate, PM]]: [[NADH electron transfer-pathway state |N-pathway]]
  10 KB (1,407 words) - 19:20, 9 February 2022
• SUIT-011 O2 pfi D024
  ...b>''P''</sub>. SUIT-004 should be chosen for the additive effect in the ET-state. ...state in[[NS-pathway control state| NS-]] and [[Succinate pathway control state| S-pathways]] can be assessed.
  5 KB (784 words) - 11:18, 17 September 2020
• Lenaz 2007 Am J Physiol Cell Physiol
  ...ansfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling. Am J Physiol Cell Physiol 292:C1221-39. doi: 10.1152/a
  2 KB (246 words) - 12:50, 25 March 2021
• Oliveira 2011 Insect Biochem Mol Biol
  ...er expression levels of several glycolytic enzyme genes. Furthermore, when State 3 respiration was reduced in S females by silencing expression of the adeni
  2 KB (231 words) - 10:03, 9 November 2016
• Gnaiger 2011 Abstract-MonteVerita
  ...ation increases linearly with respiratory capacity controlled by metabolic state, from 0.2 to 1.6 µM determined by [[high-resolution respirometry]]. O_{3 KB (393 words) - 18:20, 10 January 2022
• SUIT-015
  ...ration#The_LEAK_state |LEAK state]] and [[Oxidative phosphorylation|OXPHOS state]]''' ...osphorylation|OXPHOS state]] and of [[FNS]] and [[S]] in [[ET capacity| ET state]] can be evaluated. SUIT-015 can be extended with the CIV assay module.
  3 KB (393 words) - 15:21, 8 June 2020
• SUIT-014
  ...and ET state ([[NS-pathway control state|NS]], [[Succinate pathway control state|S]]) is also evaluated, covering the contribution of two pathways which are ...b>''P''}. SUIT-004 should be chosen for the additive effect in the ET-state.
  4 KB (634 words) - 15:21, 8 June 2020
• Makrecka-Kuka 2015 Biomolecules
  ...hest in the succinate-linked LEAK state, reduced with [[NS-pathway control state |NS-linked convergent electron flow]] and in mitochondria respiring at OXPH
  4 KB (484 words) - 19:56, 7 January 2024
• SUIT-008
  |info='''A: Additivity between the N- and [[Succinate pathway control state| S-pathway]] in the Q-junction''' ...NADH_Electron_transfer-pathway_state| N-]] and [[Succinate pathway control state| S-pathway]] in the [[Q-junction]], providing a physiologically relevant es
  4 KB (668 words) - 09:41, 30 November 2023
• Gnaiger 1998 Biochim Biophys Acta
  ...ncy, ''J''max/''p''₅₀, increased from the resting to the active state, despite the decrease of oxygen affinity, 1/''p''₅₀. Consequentl ::::* [[State 2]] in this publication has the meaning of a [[LEAK]] state of respiration, without added adenylates (no ADP and no ATP) in the presenc
  4 KB (505 words) - 16:27, 24 April 2023
• Toleikis 2020 Cells
  ...osine diphosphate (ADP)/adenosine triphosphate (ATP) carrier (M-state to C-state, condensed to orthodox mitochondria) may affect the oxidative phosphorylati
  2 KB (266 words) - 17:03, 5 October 2023
• SUIT-016
  ...ration#The_LEAK_state |LEAK state]] and [[Oxidative phosphorylation|OXPHOS state]]''' ...] in [[LEAK respiration#The_LEAK_state |LEAK state]] and [[ET capacity| ET state]] is evaluated.
  4 KB (543 words) - 15:19, 8 June 2020
• Pallag 2022 Int J Mol Sci
  ...of oxygen consumption, membrane potential, NADH, and the ubiquinone redox state were correlated to ProDH activity and F₁F_O-ATPase dir |topics=mt-Membrane potential, Redox state
  3 KB (409 words) - 15:12, 9 December 2022
• Residual oxygen consumption
  ...hondrial respiration is frequently corrected for ''Rox'' as the [[baseline state]]. Then, total [[ROUTINE]], [[LEAK respiration]], [[OXPHOS]] or [[Electron ...BEC MitoPathways]]), the [[REN]] state was not distinguished from the ROX state. However, in novel applications (Q-Module and NADH-Module), a distinction o
  10 KB (1,409 words) - 08:36, 25 November 2023
• LEAK state with ATP
  ...0 Proc Natl Acad Sci U S A |Gnaiger et al 2000]]). Respiration in the LEAK state with ATP, ''L''(T), is distinguished from ''L''(n) and ''L''(Omy). == The LEAK state of respiration: towards a concept-linked terminology of respiratory states
  1 KB (149 words) - 01:12, 31 December 2020
• Komlodi 2017 Abstract MITOEAGLE Barcelona
  ...ADP added to S(-Rot) inhibited oxygen consumption with respect to the LEAK state at low succinate concentration in guinea pig brain and heart, but even at h ...ndogenously produced oxaloacetate (Oa), which is particulaly pronounced in state S(-Rot) [4]. However, exogenously added Oa inhibited SDH measured in brain
  6 KB (912 words) - 18:51, 10 January 2022
• Srivastava 2016 Clin Transl Med
  ...ys, and through their activation, NAD(+) directly links the cellular redox state with signaling and transcriptional events. NAD(+) levels decline with mitoc
  3 KB (344 words) - 17:37, 5 October 2023
• McCommis Kyle S
  |state=Missouri (MO)
  327 bytes (43 words) - 09:24, 4 September 2023
• Elasticity
  ...ken at the metabolite concentrations found in the pathway in the metabolic state of interest. It can be obtained directly as the slope of the logarithm of t
  1 KB (151 words) - 11:53, 25 November 2020
• Pesta 2012 Methods Mol Biol
  ...[[dyscoupling]] is evaluated as a mitochondrial defect. The [[noncoupled]] state of maximum respiration is experimentally induced by titration of establishe
  8 KB (1,056 words) - 10:11, 23 May 2022
• SUIT-005
  |info='''A:''' when [[Malate-anaplerotic pathway control state |malate-anaplerotic activity]] is zero ...onvergence [[FNS |FNS]] pathways in the [[Oxidative phosphorylation|OXPHOS state]]. [[FNS |FNS]] comprises the most important pathways in many cell types an
  3 KB (424 words) - 14:30, 10 March 2023
• SUIT-002 O2 pfi D006
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  3 KB (439 words) - 18:44, 5 March 2024
• Bialas 2018 Int J Chron Obstruct Pulmon Dis
  ...sub>=0.04. The study group also demonstrated lowered respiration in the ET-state (normalized for protein content): 12.31 (4.84) vs 16.48 (1.72) (pmol O<sub>
  3 KB (430 words) - 00:24, 16 February 2020
• SUIT-004 O2 pfi D010
  ...ity| ''E'']]) with NADPH-linked substrate substrates ([[PM-pathway control state|PM]]). ...y_state|N]], [[NS-pathway control state| NS]], [[Succinate pathway control state| S]]).
  3 KB (354 words) - 23:49, 12 April 2021
• SUIT-018 AmR mt D040
  ...lso advisable to either detect H₂O₂ flux at the same state for high (tissue hyperoxia; [O₂]> ~100-110 µM) and low (tissue ...end of the protocol to study the effect of oxygen concentration in the ROX state (in the presence of Ama) both on the O₂ and H₂O<sub>2
  4 KB (625 words) - 12:09, 7 March 2024
• Vinogradov Andrei D
  Moscow State University :::: Andrei started his scientific career at Moscow State University in the former USSR in 1964. He obtained his postdoctoral trainin
  3 KB (345 words) - 09:25, 11 May 2024
• Hall 2013 Biochim Biophys Acta
  ...2]] and [[State 4o]] oxygen flux as well as lowered ADP phosphorylation ([[State 3]]) and mitochondrial ATP synthesis. Polycation-mediated reduction of elec
  3 KB (327 words) - 11:13, 22 November 2023
• Zuccolotto-dos-Reis 2021 MitoFit ACoAR
  ...oes fresh homogenate (used as a reference for cryopreservation) compare to state-of-the-art mitochondrial preparations of (human) skeletal muscle tissue? Ev
  4 KB (558 words) - 08:43, 8 January 2023
• Kontro 2016 Thesis
  Statistical analysis showed a significant difference in the LEAK respiration state (P<0.05) and LEAK control ratio (P<0.01) between young and old LCR rats (L: ...R show a decline in their OXPHOS and ET capacity with age, but not in LEAK state respiration.
  3 KB (424 words) - 14:57, 13 November 2017
• Garcia Geovana S
  São Paulo State University -Jaboticabal campus (FCAV-UNESP); São Paulo State University - São José do Rio Preto campus (IBILCE-UNESP), BR
  647 bytes (84 words) - 15:24, 16 March 2020
• LEAK respiration
  ...easurement and expression of respiration vary ([[oxygen flux]] in the LEAK state, ''J''_O₂''L'', or [[oxygen flow]], ''I''<sub>O<sub>2< ...stem and in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI<small>&</small>II-linked substrate supply
  12 KB (1,658 words) - 01:03, 31 December 2020
• SUIT-002
  ...ays) and in [[ET capacity| ET state]] ([[FNSGp]] and [[SGp-pathway control state|SGp]]) can be evaluated by using this SUIT protocol. SUIT-002 can be extend :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d
  6 KB (809 words) - 18:41, 5 March 2024
• US MO St Louis McCommis KS
  |state=Missouri (MO)
  378 bytes (54 words) - 09:25, 4 September 2023
• Dantas Wagner S
  |state=Louisiana (LA)
  354 bytes (43 words) - 08:37, 15 April 2024
• Chen 2022 Am J Physiol Cell Physiol
  ...contribute to •O2− generation in the respiratory conditions of state 2 and state 4. Black circles show aconitase of the Krebs Cycle that generates NADH and |topics=Redox state
  5 KB (754 words) - 03:39, 11 November 2023
• Goetzman Eric S
  |state=Pennsylvania (PA)
  332 bytes (38 words) - 17:51, 29 February 2020
• SUIT-031 Q mt D072
  ...analyse O2 flux and the Q-redox state in the N-,NS- and S- pathway control state on isolated mitochondria- '''[[SUIT-031]]''' ...to be determined if used. Higher concentrations of Omy may inhibit the ET state.
  4 KB (530 words) - 16:17, 13 December 2023
• Gopalakrishnan 2020 Sci Rep
  ...Ranji M, Eells JT (2020) Photobiomodulation preserves mitochondrial redox state and is retinoprotective in a rodent model of retinitis pigmentosa. Sci Rep ...sham-treated group. PBM protected against the disruption of the oxidation state of the mitochondrial respiratory chain observed in sham-treated animals. Sc
  3 KB (395 words) - 04:44, 4 November 2023
• Kunz 1994 Anal Biochem
  ...nase reached after addition of 1 mM ADP correlates with the rate of active state respiration with NAD-dependent substrates. Therefore, this fluorimetric met
  2 KB (339 words) - 10:43, 23 January 2019
• Aid-Vanakova 2019 MiP2019
  ...bstrate, no significant difference was detected. At the same time the leak state without adenylates is higher in Wfs1KO in most muscles with both complex I
  5 KB (679 words) - 09:31, 2 September 2019
• Du 2015 Aquat Toxicol
  ...exposure and undosed fish show decreased LEAK and increased State 3 and E state.
  2 KB (339 words) - 17:51, 9 November 2017
• Fatty acid oxidation
  :» [[F-pathway control state]]
  4 KB (596 words) - 09:27, 8 May 2023
• Reiss 2022 Exp Gerontol
  ...ets and evaluates neuroprotective agents that could improve the functional state of mitochondria in the setting of AD.
  2 KB (290 words) - 15:57, 19 December 2023
• Enriquez 2014 Mol Syndromol
  | solid model || ↔ || solid state model | random collision model || ↔ || liquid state model
  11 KB (1,555 words) - 15:37, 16 July 2023
• SUIT-019 O2 pfi D045
  ...n the absence of other, potentially interfering pathways, both in the LEAK state and in OXPHOS. ...ays) and in [[ET capacity| ET state]] ([[FNSGp]] and [[SGp-pathway control state|SGp]]) can be evaluated by using this SUIT protocol.
  3 KB (424 words) - 14:38, 17 September 2020
• Stadlmann 2006 Cell Biochem Biophys
  ...s ([[Permeabilized tissue or cells |pce]]). dce without substrate are in a state of ROX_dce. ...ected by extracellular succinate and ADP (SD); dce (with intact mt) are in state S_''P'',dce. ''Limitation'': In the absence of rotenone, S-OXPHOS
  12 KB (1,918 words) - 13:59, 27 December 2021
• Yuan 2022 Oxid Med Cell Longev
  ...servation. Overnutrition causes nonspecific, persistently low inflammatory state known as metabolic inflammation. This condition contributes to the pathophy
  1 KB (194 words) - 11:04, 22 March 2023
• SUIT-031 Q ce-pce D074
  ...'A''' to analyse O2 flux and the Q-redox state in the NS- pathway control state on permeabilized cells- '''[[SUIT-031]]''' ...to be determined if used. Higher concentrations of Omy may inhibit the ET state.
  4 KB (519 words) - 17:52, 13 December 2023
• Edman Sebastian
  |state=
  377 bytes (43 words) - 12:20, 20 June 2023
• Yoval-Sanchez 2022 Redox Biol
  ...ng its flavin mononucleotide (FMN) cofactor when maintained in the reduced state in conditions of RET both ''in vitro'' and ''in vivo''. Here we investigate
  3 KB (440 words) - 12:07, 5 December 2022
• SUIT-002 O2 mt D005
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  4 KB (508 words) - 18:44, 5 March 2024
• Quintard 2018 Springer, Cham
  |abstract=Our survival state depends on serial metabolic reactions needing energy. Our environmental fee
  807 bytes (116 words) - 15:22, 19 December 2023
• Michalak 2017 Oxid Med Cell Longev
  ...ols. Decreased ROUTINE respiration (P = 0.007) and oxygen flux in the LEAK state (P = 0.0203) were observed in patients with PD with substantia nigra hypere
  2 KB (313 words) - 23:24, 29 February 2020
• SUIT-017
  ...osphorylation|OXPHOS state]] and of [[FNS]] and [[S]] in [[ET capacity| ET state]] is evaluated.
  2 KB (325 words) - 23:49, 12 April 2021
• US PA Pittsburgh Goetzman ES
  |state=Pennsylvania (PA)
  563 bytes (69 words) - 18:15, 20 August 2023
• SUIT-009 O2 mt D015
  ::: + Cytochrome ''c'' test can be performed in the S-OXPHOS state.
  2 KB (312 words) - 23:50, 12 April 2021
• SUIT-006 O2 ce-pce D029
  ...alyse the coupling control on permeabilized cells in N(PM) pathway control state- '''[[SUIT-006]]'''
  2 KB (290 words) - 23:58, 12 April 2021
• Lark DS
  |state=North Carolina (NC)
  207 bytes (25 words) - 15:56, 19 August 2014
• Hand 2012 Abstract Bioblast
  ...tory Complex I (pyruvate&malate) are used as the fuel source in the OXPHOS state (Fig. 1). Reduced respiration through Complex I is supported by Western blo (1) Department of Biological Sciences, Louisiana State University, Baton Rouge, USA; Email: [email protected]
  5 KB (683 words) - 11:16, 8 June 2020
• Hara 2013 Eur J Anaesthesiol
  ...sis group (''P'' = 0.077) and a minor non-significant increase in the LEAK state (''P'' = 0.262) resulting in a statistically significant decreased respirat
  3 KB (428 words) - 13:45, 7 March 2020
• SUIT-008 O2 ce-pce D025
  ...with NP + SP. SUIT-004 should be chosen for the additive effect in the ET-state. ...'L''- ''P''- ''E'') with NADH linked-substrates (PM) and the control in ET state (N, NS, S)
  3 KB (516 words) - 23:58, 12 April 2021
• Doerrier 2018 Methods Mol Biol
  ...logical dyscoupling is evaluated as a mitochondrial defect. The noncoupled state of maximum respiration is experimentally induced by titration of establishe
  6 KB (850 words) - 12:27, 5 March 2024
• Silva 2019 MiPschool Coimbra
  ...of etomoxir on isolated liver mitochondria was also observed in the OXPHOS state, without minor inhibitory effect on FAO. These results suggest that FAO can ...in the presence of 200 µM etomoxir. (A) FCR in OXPHOS-state. (B) FCR in ET-state. The results are expressed as median and interquartile range of 4 independe
  7 KB (977 words) - 19:13, 10 January 2022
• SUIT-002 O2 ce-pce D007
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  4 KB (557 words) - 12:52, 12 April 2023
• SUIT-026
  ...dded to the chamber). The protocol is focused on [[LEAK respiration|LEAK]] state for the [[S-pathway]] to provide the conditions of high membrane potential ...an Event&Mark for the uncoupler titration (4U) after ADP (3D) to obtain ET-state.
  5 KB (809 words) - 12:39, 24 January 2024
• SUIT-008 O2 mt D026
  ...'P''-''E'') with NADH linked-substrates (PM) and the pathway control in ET state (N, NS, S pathways).
  3 KB (433 words) - 10:56, 17 September 2020
• Palasiewicz Karol
  |state=Illinois (IL)
  235 bytes (28 words) - 11:12, 14 April 2022
• Dang 2014 Plant Cell
  ...in the pgrl1 mutant, resulting in normal biomass productivity under steady state conditions. The lower biomass productivity observed in the pgrl1 mutant in
  2 KB (290 words) - 15:13, 8 August 2023
• SUIT-002 O2 ce-pce D007a
  :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.
  4 KB (572 words) - 08:25, 12 October 2020
• Gnaiger 2015 Abstract MiPschool Cape Town 2015 II
  ...o zero in a fully coupled system. Maximal efficiency in the ADP-stimulated state of oxidative phosphorylation (OXPHOS) is, however, not adaptive [1] and is ...g lower the efficiency and contribute to the control of flux in the OXPHOS state. ADP and inorganic phosphate do not equilibrate across the plasma membrane,
  13 KB (2,089 words) - 18:19, 7 November 2020
• US PA Pittsburgh Votyakova TV
  |state=Pennsylvania (PA)
  323 bytes (40 words) - 12:04, 13 August 2012
• Sidossis LS
  |state=Texas (TX)
  202 bytes (26 words) - 16:52, 18 August 2014
• SUIT-008 O2 pfi D014
  ...with NP + SP. SUIT-004 should be chosen for the additive effect in the ET-state. ...'L''- ''P''- ''E'') with NADH linked-substrates (PM) and the control in ET state (N, NS, S)
  4 KB (539 words) - 23:48, 12 April 2021
• Stepanova 2018 J Cereb Blood Flow Metab
  ...lysed and complexome profiling was performed. The effect of conformational state (active/deactive (A/D) transition) of mitochondrial complex I on H<sub>2</s
  3 KB (373 words) - 21:42, 13 April 2022
• Doerrier 2012 Abstract Bioblast
  |topics=Redox state
  4 KB (548 words) - 11:15, 8 June 2020
• Bioblast alert 2014
  ...: Respiratory states |MitoPedia]]: [[LEAK respiration |'''Respiratory LEAK state: concept-linked terminology''']] ...Respiratory states |MitoPedia]]: [[ET capacity |'''Why ET-pathway, why not State 3u?''']]
  5 KB (611 words) - 15:14, 8 June 2020
• Doerrier 2015 Abstract MiP2015
  ...icated in the pathogenesis of many diseases. In particular, the NADH redox state is related to ROS production. Succinate is a substrate of succinate dehydro
  7 KB (948 words) - 18:37, 10 January 2022
• Doerrier 2015 Abstract MiPschool Greenville 2015
  ...rometer using Amplex Ultrared [2]. In addition, respiration and NADH redox state were measured with a prototype NextGen-O2k, which combines high-resolution ...DP added to S inhibited oxygen consumption by 30% with respect to the LEAK state (SL), which is the so-called “succinate paradox” [3]. This paradox was
  5 KB (714 words) - 18:35, 10 January 2022
• Miller 2017 PLOS ONE
  ...2017) Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race. PLOS ONE 12:e0174874.
  3 KB (438 words) - 12:52, 27 December 2021
• The protonmotive force and respiratory control
  ...bbreviations (mtDNA, mt to abbreviate mitochondr*); OXPHOS capacity versus State 3 (discuss saturating ADP/Pi .. concentrations). ::::* '''[[State 2]]'''
  12 KB (1,564 words) - 23:40, 25 January 2021
• Dhillon RS
  |state=Wisconsin (WI)
  452 bytes (56 words) - 14:04, 13 May 2019
• Volt 2014 Abstract SECF
  |abstract=Inflammaging involves a persistent pro-inflammatory state coursing with cardiac and energy metabolism alterations. This chronic, subc ...leads us to explore this pathway and its relation with the hyperoxidative state of aging.
  3 KB (374 words) - 08:53, 30 May 2016
• Iglesias-Gonzalez 2013 J Neurosci Methods
  ...ivity cannot be quantified in the active state ([[State 3]]; [[OXPHOS]] or State ''P''), but uncoupler titrations are required to determine the [[ET-capacit
  3 KB (349 words) - 14:26, 3 June 2020
• SUIT-006 Q mt D071
  ...b> consumption and the redox state of the Q-pool in S(Rot)-pathway control state in isolated mitochondria- '''[[SUIT-006]]''' ...to be determined if used. Higher concentrations of Omy may inhibit the ET state.
  3 KB (404 words) - 14:23, 18 December 2023
• Kristal Bruce S
  |state=Massachusetts (MA)
  485 bytes (65 words) - 16:28, 16 March 2020
• Facucho-Oliveira 2009 Stem Cell Rev Rep
  ...is hypothesized that reprogramming of somatic cells towards a pluripotent state, by somatic cell nuclear transfer (SCNT), transcription-induced pluripotenc
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• SUIT-001
  ...[[FNS]], [[Succinate pathway control state| S]] and [[SGp-pathway control state| SGp]] pathways) can be evaluated by using this SUIT protocol. SUIT-001 can :::+ Pathway control in ET state (N, NS, FNS, S and SGp pathways).
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• Silva 2019 ESCI2019
  ...he anaplerotic pathways [5]), etomoxir did not influence FAO in the OXPHOS state on Huh7 cells, while on mitochondria respiring on palmitoyl-CoA (40 µM) +
  5 KB (697 words) - 19:11, 10 January 2022
• Dumollard 2007 Development
  ...ate impairs development, demonstrating the fundamental importance of redox state on early development.
  2 KB (298 words) - 07:09, 11 October 2023
• Risiglione 2020 Int J Mol Sci
  ...try, we deeply investigated oxygen consumption related to each respiratory state in differentiated neuroblastoma cells exposed to the neurotoxin. Our result
  3 KB (367 words) - 17:36, 5 October 2023
• Agil 2015 J Pineal Res
  ...001) and complex IV of electron transfer chain (''P'' < 0.05) and enhances state 3 respiration (''P'' < 0.001), respiratory control index (RCR) (''P'' < 0.0
  3 KB (337 words) - 08:04, 21 February 2020
• Lemieux 2019a MiP2019
  ...ration (before the addition of ADP), OXPHOS capacity (in the ADP-activated state, coupled oxidative phosphorylation) and ET capacity (electron transfer capa
  6 KB (903 words) - 13:12, 26 September 2019
• Collier S
  |state=Missouri (MO)
  261 bytes (33 words) - 09:34, 19 December 2014
• Volt 2014 Abstract The 2014 Ageing Summit
  ...-related changes of the immune system involve a persistent proinflammatory state. This subclinical and chronic inflammation contributes further to enhance t
  2 KB (288 words) - 17:34, 7 November 2016
• Ismaeel Ahmed
  |state=Kentucky (KY)
  278 bytes (36 words) - 13:38, 11 January 2023
• US LA Baton Rouge Hand SC
  Louisiana State University |state=Louisiana (LA)
  1 KB (145 words) - 11:06, 21 July 2022
• Spielmann 2022 Mamm Genome
  ...y through the electron transfer system (ETS) simultaneously with the redox state of ETS-reactive coenzyme Q (Q), or production of reactive oxygen species (R |topics=ADP, mt-Membrane potential, Redox state, Substrate, Q-junction effect
  4 KB (506 words) - 19:30, 5 March 2023
• Tomar 2022 Biochim Biophys Acta Bioenerg
  ...OM mitochondria OxPhos efficiencies were higher than cortex mitochondria. State 3 respiration was low in heart mitochondria with succinate but increased si
  3 KB (386 words) - 11:58, 27 March 2023
• Margulies SS
  |state=Pennsylvania (PA)
  266 bytes (31 words) - 09:17, 16 February 2018
• Kozlov 2009 Biochim Biophys Acta
  ...or (AIF) to the nucleus, suggesting that the cells entered a pre-apoptotic state, but apoptosis was not executed. Monooxygenase activity of p450, representi
  2 KB (331 words) - 15:15, 20 March 2015
• Garcia 2019 MiPschool Coimbra
  ...and 25°C. Surprisingly, no differences in coupled respiration and state 3/state 4 ratio were detected when substrates to the two main dehydrogenases in fli ...nects cytosolic processes with ETS, we can predict that the cellular redox state of the larvae is altered in the presence of AOX, affecting other metabolic
  4 KB (606 words) - 15:44, 26 June 2019
• Aon 2010 Biochim Biophys Acta
  ...le keeping ROS overflow to a minimum by operating in an intermediate redox state. We show that at the extremes of reduction or oxidation of the redox couple
  2 KB (323 words) - 21:46, 24 September 2021
• Droese 2009 Biochim Biophys Acta
  ...ffects of diazoxide reported in the literature. Depending on the metabolic state and the membrane potential of mitochondria, diazoxide-mediated inhibition o
  3 KB (376 words) - 16:49, 19 February 2018
• Finck Brian N
  |state=Missouri (MO)
  267 bytes (36 words) - 09:16, 4 September 2023
• Penjweini 2020 Redox Biol
  ...escence lifetime imaging (FLIM)-based measurement of nicotinamide coenzyme state. This offers a contemporaneous reading of metabolic activity through real-t
  2 KB (269 words) - 15:19, 5 November 2023
• Ravasz 2024 Sci Rep
  |topics=mt-Membrane potential, Redox state
  2 KB (328 words) - 11:09, 27 January 2024
• SUIT-038 O2 mt D091
  :::+ Pathway control in OXPHOS (N, NS, NSGp pathways) and in ET state (NSGp and SGp) can be observed. :::- LEAK state is not investigated.
  2 KB (332 words) - 11:21, 14 April 2023
• Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis
  ...ion rates, electron transfer system (ETS)-related coenzyme Q (mtCoQ) redox state and production of reactive oxygen species (ROS) in mouse brain and liver mi |topics=Redox state, Q-junction effect
  2 KB (345 words) - 09:44, 28 February 2024
• Bernstein D
  |state=Connecticut (CT)
  296 bytes (34 words) - 14:03, 13 May 2019
• Dufour S
  |state=Connecticut (CT)
  322 bytes (37 words) - 15:30, 21 August 2014
• Laner 2015 Abstract MiPschool Greenville 2015
  ...ked substrates. Both protocols were designed to provide a common reference state of CI&II-linked ET capacity, in comparison to separate Complex I- and Compl ..., 5Comparative Exercise Physiol Lab, Center Veterinary Health Sc, Oklahoma State Univ, Stillwater, OK, US; 5-D Swarovski Research Lab, Dep Visceral Transpla
  5 KB (640 words) - 18:36, 10 January 2022
• Blecha 2017 Free Radic Biol Med
  ...smal level remains unclear. As most somatic cells are in non-proliferative state, the features associated with the ETC in quiescence could account for some
  3 KB (402 words) - 12:26, 27 November 2017
• Kingren Meagan
  |state=Arkansas (AR)
  300 bytes (35 words) - 12:24, 15 April 2024
• Specht KS
  |state=Virginia (VA)
  274 bytes (36 words) - 18:02, 28 August 2018
• DeBoer E
  |state=Pennsylvania (PA)
  286 bytes (34 words) - 11:15, 19 August 2019
• US CO Fort Collins Hamilton K
  |institution=Colorado State University |state=Colorado (CO)
  676 bytes (89 words) - 19:05, 20 November 2018
• SUIT-006 Q ce-pce D073
  ...b> consumption and the redox state of the Q-pool in S(Rot)-pathway control state in permeabilized cells- '''[[SUIT-006]]''' ...to be determined if used. Higher concentrations of Omy may inhibit the ET state.
  3 KB (443 words) - 14:38, 18 December 2023
• SUIT-009 O2 ce-pce D016
  :::+ Cytochrome ''c'' test can be performed in the S-OXPHOS state.
  2 KB (312 words) - 00:09, 13 April 2021
• Schappe T
  |state=Missouri (MO)
  318 bytes (40 words) - 09:47, 19 December 2014
• Rich 1984 Biochim Biophys Acta
  ...med 'liquid state' and 'solid state' (Figs. 1A and B) [19,20]. In a liquid-state system, one or all components are freely diffusing and hence randomly arran ...exchange between free and bound forms of ubiquinone occurs. In such 'solid-state' reactions, reaction rate becomes limited by an internal rate constant of o
  12 KB (1,791 words) - 15:27, 16 July 2023
• US MA Boston Kristal BS
  |state=Massachusetts (MA)
  614 bytes (76 words) - 09:38, 6 September 2021
• Dutton 1989 Arch Biochem Biophys
  ...on formation. Superoxide dismutase, but not catalase, increased the steady-state level of reduced resorufin and considerably delayed its reoxidation. This i
  3 KB (422 words) - 21:45, 24 September 2021
• Czerniczyniec 2015 J Bioenerg Biomembr
  ...t on respiratory chain. An increase of 2.2 fold in state 4 and 2.3 fold in state 3 in KCN-insensitive respiration was observed in striatal mitochondria from
  3 KB (338 words) - 12:00, 11 July 2017
• Clanton 2013 Compr Physiol
  ...hways. Particular attention is paid to how O₂ affects the redox state of the cell, as well as the NO, H₂S, and CO concentrations. We a
  2 KB (342 words) - 06:57, 28 June 2022
• Sharpe 2021 Front Oncol
  ...can be toxic to cancer cells. Because weak magnetic fields influence spin state pairing in redox-active radical electron pairs, we hypothesize that they di
  2 KB (351 words) - 05:49, 6 February 2024
• Chao 2019 Am J Physiol Cell Physiol
  ...phosphorylation. Coupled Complex-1 respiration decreased, while uncoupled State-4O, and complex-II increased significantly due to burn injury, particularly
  3 KB (356 words) - 11:41, 3 March 2020
• Gruenig 2017 Toxicol In Vitro
  ...mulated state 2 complex II-linked respiration and both compounds inhibited state 3 respiration of complex IV. Mitochondrial uncoupling was confirmed for bot
  3 KB (332 words) - 11:25, 27 June 2019
• Ostrovsky J
  |state=Pennsylvania (PA)
  337 bytes (38 words) - 09:31, 23 May 2017
• Second
  ...value of the caesium frequency ∆''ν''_Cs, the unperturbed ground-state hyperfine transition frequency of the caesium 133 atom, to be 9 192 631 770
  1,018 bytes (147 words) - 15:23, 3 April 2022
• SUIT-003
  ...commended in the SUIT-003 have been designed to study the coupling control state of living cells. In order to study the [[LEAK respiration]], the phosphoryl
  6 KB (974 words) - 13:11, 17 November 2023
• Votyakova Tatyana V
  |state=Pennsylvania (PA)
  502 bytes (61 words) - 17:58, 29 February 2020
• Bouillaud 2013 Abstract MiP2013
  ...oncentration requires to be lower than 10 µM the establishment of a steady state for sulfide oxidation requires a continuous infusion of sulfide [4]. Becaus
  6 KB (870 words) - 11:04, 28 April 2017
• Hu 2017 Proc Natl Acad Sci U S A
  ...'-tetramethyl-p-phenylenediamine (TMPD)+ascorbate. Interestingly, at basal state, cHet mice exhibited a higher H₂O₂ level in the cytos
  3 KB (391 words) - 00:34, 1 March 2020
• Hempenstall 2012 Mech Ageing Dev
  == Comment: Resting state == ...'starvation state' is strictly distinguished from metabolism in a 'resting state'. Mitochondria in the absence of added carbon-substrates are starved, gradu
  4 KB (512 words) - 10:30, 20 October 2017

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