Difference between revisions of "Schlattner 2018 MiPschool Tromso B1"
Beno Marija (talk | contribs) (Created page with "{{Abstract |title=left|90px|Mitochondrial Physiology Society|MiPsociety |info=MitoEAGLE |authors=Schlattner U |year=2018 |event=MiPschool Tromso-B...") |
|||
| Line 1: | Line 1: | ||
{{Abstract | {{Abstract | ||
|title=[[File:SchlattnerU.jpg|left|90px| | |title=[[File:SchlattnerU.jpg|left|90px|Uwe Schlattner]]Mitochondrial kinases: key players in respiratory control and energy transfer. | ||
|info=[[MitoEAGLE]] | |info=[[MitoEAGLE]] | ||
|authors=Schlattner U | |authors=Schlattner U | ||
| Line 6: | Line 6: | ||
|event=MiPschool Tromso-Bergen 2018 | |event=MiPschool Tromso-Bergen 2018 | ||
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]] | |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]] | ||
|editor=[[Beno M]], | Mitochondrial isoforms of nucleoside diphosphate kinase (NDPK-D or NME4) and creatine kinase (mtCK) are phylogenetically unrelated but share important structural and functional properties. They are both located in the intermembrane/cristae space and use mitochondrially generated ATP to phosphorylate their specific substrates, NDPs or creatine, thus regenerating ADP within the mitochondria. Both enzymes functionally interact with inner membrane adenylate translocator, thus allowing for privileged exchange (channeling) of these metabolites. We will discuss the molecular basis of this metabolite channeling and its functional consequences beyond the simple maintenance of proper nucleotide pools: stimulation of respiration, “energy export”, and regulation of ROS production, permeability transition and mitochondrial shape. | ||
|editor=[[Beno M]], [[Plangger M]], | |||
|mipnetlab=FR Grenoble Schlattner U | |||
}} | |||
{{Labeling | |||
|area=Respiration | |||
|instruments=Oxygraph-2k | |||
}} | }} | ||
== Affiliations == | == Affiliations == | ||
::::Lab Fundamental Applied Bioenergetics SFR Environmental Systems Biology, Univ Grenoble Alpes Inserm, Grenoble, France | |||
Revision as of 13:46, 18 September 2018
 |
Link: MitoEAGLE
Schlattner U (2018)
Event: MiPschool Tromso-Bergen 2018
Mitochondrial isoforms of nucleoside diphosphate kinase (NDPK-D or NME4) and creatine kinase (mtCK) are phylogenetically unrelated but share important structural and functional properties. They are both located in the intermembrane/cristae space and use mitochondrially generated ATP to phosphorylate their specific substrates, NDPs or creatine, thus regenerating ADP within the mitochondria. Both enzymes functionally interact with inner membrane adenylate translocator, thus allowing for privileged exchange (channeling) of these metabolites. We will discuss the molecular basis of this metabolite channeling and its functional consequences beyond the simple maintenance of proper nucleotide pools: stimulation of respiration, “energy export”, and regulation of ROS production, permeability transition and mitochondrial shape.
• Bioblast editor: Beno M, Plangger M
• O2k-Network Lab: FR Grenoble Schlattner U
Labels: MiParea: Respiration
HRR: Oxygraph-2k
Affiliations
- Lab Fundamental Applied Bioenergetics SFR Environmental Systems Biology, Univ Grenoble Alpes Inserm, Grenoble, France
