Oroboros Laboratory: Difference between revisions
From Bioblast
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Template:OROBOROS header page name}} | {{Template:OROBOROS header page name}} | ||
[[File:OROBOROS MitoFit-Lab.jpg|right|240px |MitoFit Laboratory]] | |||
== About us == | == About us == | ||
[[Image:Logo MitoFit.jpg|left|120px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]] | [[Image:Logo MitoFit.jpg|left|120px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]] | ||
| Line 33: | Line 34: | ||
According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world. | According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world. | ||
[[OROBOROS_MitoFit_lab:_visiting_scientists| Visiting scientists]] | :: [[OROBOROS_MitoFit_lab:_visiting_scientists |'''» Visiting scientists in the MitoFit lab''']] | ||
[[File:ORO Lab 1.jpg|250px]] [[File:ORO Lab 2.jpg|250px]] [[File:ORO Lab 3.jpg|250px]] [[File:ORO Lab 4.jpg|250px]] | [[File:ORO Lab 1.jpg|250px]] [[File:ORO Lab 2.jpg|250px]] [[File:ORO Lab 3.jpg|250px]] [[File:ORO Lab 4.jpg|250px]] | ||
| Line 56: | Line 57: | ||
=== Oncotyrol | === Oncotyrol === | ||
:::: '''Prostate cancer''' | |||
:::: The [[Oncotyrol| Oncotyrol]] research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue, and comparison of primary tissue with cultured cells. - [http://oroboros.at/index.php?id=oncotyrol Oncotyrol] | |||
:::: Project leader: A.Univ. Prof. Mag. Dr. Helmut Klocker, Dept. Urology, Medical University Innsbruck, Austria | |||
::::'''[[Weber A| Anja Weber]]''', Mag., PhD student - [mailto:[email protected] [email protected]] | |||
[[Image:SchoepfB.jpg|left|90px]] | [[Image:SchoepfB.jpg|left|90px]] | ||
:: '''[[Schoepf B|Bernd Schoepf]]''', Mag., PhD student - [mailto:[email protected] [email protected]] | :: '''[[Schoepf B|Bernd Schoepf]]''', Mag., PhD student - [mailto:[email protected] [email protected]] | ||
<br/> | <br/> | ||
<br/> | <br/> | ||
<br/> | <br/> | ||
::::'''[[Weber | :::: '''Onctyrol phasing out''' | ||
:::: | :::: Project leader: Univ.-Prof. Dr. Zlatko Trajanoski, Biozentrum Innsbruck - Sektion für Bioinformatik, Medical University Innsbruck, Austria | ||
::::'''[[Weber B| Benno Weber]]''', Mag., Scientific assistant - [mailto:benno.weber@oncotyrol.at benno.weber@oncotyrol.at] | |||
::::'''[[Laschober G| Gerhard Laschober]]''', Mag., PhD, Postdoc - [mailto:[email protected].at [email protected].at] | |||
=== Pharmacology | === Pharmacology: mitochondrial function in brain tissues === | ||
[[Image:Johannes.jpg|left|90px|Johannes Burtscher]] | [[Image:Johannes.jpg|left|90px|Johannes Burtscher]] | ||
:: '''[[Burtscher J|Johannes Burtscher]]''', Mag., PhD student | :: '''[[Burtscher J|Johannes Burtscher]]''', Mag., PhD student | ||
:: FWF projects W1206-B05 and I-977-B24. | :: FWF projects W1206-B05 and I-977-B24. | ||
:: Project leader: A.Univ. Prof. Dr. Christian Schwarzer, Dept. Pharmacology, Medical University | :: Project leader: A.Univ. Prof. Dr. Christian Schwarzer, Dept. Pharmacology, Medical University Innsbruck, Austria | ||
<br /> | |||
=== Internal Medicine === | |||
:::: '''[[Volani C| Chiara Volani]]''', [mailto:[email protected] [email protected]] | |||
:::: Project leader: Prof. Dr. Günther Weiss, Dept. of Internal Medicine, Medical University Innsbruck, Austriaq | |||
::::'''[[Volani C| Chiara Volani]]''', [mailto:[email protected] [email protected]] | |||
Revision as of 15:39, 14 December 2015
Oroboros Laboratory
About us
The OROBOROS MitoFit Laboratory (MitoFit Lab, 'Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The MitoFit Lab was opened during the course of the K-Regio project MitoCom Tyrol, starting in June 2013. It comprises 140 sqm which are divided into the office and research areas.
O2k instruments
24 O2k-Chambers (twelve O2k)
- Eight O2k instruments (16 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules are available for scientific research and routine biomedical applications.
- Two O2ks are used for specific testing.
- Two O2ks are devoted to instrumental development.
More details: OROBOROS Support
OXPHOS analysis
SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
- a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
- various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).
The MitoFit Centre of Excellence
OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous internation research institutions.
According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.
Current projects and collaborators
- The OROBOROS-Team collaborates with:
MitoFit project
- Florian Hoppel, MSc. - [email protected]
- PhD student
- Institute for Sports Science and OROBOROS: O2k-MitoFit
Oncotyrol
- Prostate cancer
- The Oncotyrol research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue, and comparison of primary tissue with cultured cells. - Oncotyrol
- Project leader: A.Univ. Prof. Mag. Dr. Helmut Klocker, Dept. Urology, Medical University Innsbruck, Austria
- Anja Weber, Mag., PhD student - [email protected]
- Bernd Schoepf, Mag., PhD student - [email protected]
- Onctyrol phasing out
- Project leader: Univ.-Prof. Dr. Zlatko Trajanoski, Biozentrum Innsbruck - Sektion für Bioinformatik, Medical University Innsbruck, Austria
- Benno Weber, Mag., Scientific assistant - [email protected]
- Gerhard Laschober, Mag., PhD, Postdoc - [email protected]
Pharmacology: mitochondrial function in brain tissues
- Johannes Burtscher, Mag., PhD student
- FWF projects W1206-B05 and I-977-B24.
- Project leader: A.Univ. Prof. Dr. Christian Schwarzer, Dept. Pharmacology, Medical University Innsbruck, Austria
Internal Medicine
- Chiara Volani, [email protected]
- Project leader: Prof. Dr. Günther Weiss, Dept. of Internal Medicine, Medical University Innsbruck, Austriaq
