From Bioblast
Description
Cytosolic and mitochondrial isoforms of malic enzyme may be specific for NAD+ or NADP+. Mitochondrial malic enzyme (mtMEN) plays an important role in anaplerosis when glucose is limiting and malate is converted to pyruvate.
Abbreviation: mtMEN
Reference: Sauer 1980 J Biol Chem
MitoPedia topics: Enzyme
References
Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
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Zelewski 1991 Eur J Biochem | 1991 | Zelewski M, SwierczyΕski J (1991) Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme. Eur J Biochem 201:339-45. | Human Rat | Liver | ||
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Nagel 1982 J Biol Chem | 1982 | Nagel WO, Sauer LA (1982) Mitochondrial malic enzymes. Purification and properties of the NAD(P)-dependent malic enzyme from canine small intestinal mucosa. J Biol Chem 257: 12405-11. | Dog | |||
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Nagel 1980 J Biol Chem | 1980 | Nagel WO, Dauchy RT, Sauer LA (1980) Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues. J Biol Chem 255:3849-54. | Rat | Heart Skeletal muscle Nervous system Liver Kidney Lung;gill Islet cell;pancreas;thymus Genital | ||
Sauer 1980 J Biol Chem | 1980 | Sauer LA, Dauchy RT, Nagel WO, Morris HP (1980) Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas. J Biol Chem 255:3844-8. | Rat | Liver | Cancer | |
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Sauer 1978 Cancer Res | 1978 | Sauer LA, Dauchy RT (1978) Identification and properties of the nicotinamide adenine dinucleotide (phosphate)+-dependent malic enzyme in mouse ascites tumor mitochondria. Cancer Res 38:1751-6. | Cancer | |||
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Mandella 1975 J Biol Chem | 1975 | Mandella RD, Sauer LA (1975) The mitochondrial malic enzymes. I. Submitochondrial localization and purification and properties of the NAD(P)+-dependent enzyme from adrenal cortex. J Biol Chem 250:5877-84. | Rat Bovines | Nervous system | ||
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