Coupling-control ratio: Difference between revisions
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== Compare == | == Compare == | ||
:::ยปย [[Coupling control factor]], ''CCF'' | |||
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== Coupling control ratios related to free capacities == | |||
* [[L/P coupling control ratio |''L/P'' coupling control ratio]], ''L/P'' | |||
:: [[Free OXPHOS capacity]], ''โP = P-L''; [[OXPHOS coupling efficiency]], ''j<sub>โP</sub>'' = (''โP'')/''P'' = 1-''L/P'' | |||
* [[L/R coupling control ratio |''L/R'' coupling control ratio]], ''L/R'' | |||
:: [[Free ROUTINE activity]], ''โR = R-L''; [[ROUTINE coupling efficiency]], ''j<sub>โR</sub>'' = (''โR'')/''R'' = 1-''L/R'' | |||
* [[LEAK control ratio]], ''L/E'' | |||
:: [[Free ETS capacity]], ''โE = E-L''; [[ETS coupling efficiency]], ''j<sub>โE</sub>'' = (''โE'')/''E'' = 1-''L/E'' | |||
* [[netOXPHOS control ratio]], ''โP/E''=(''P-L'')/''E'' | |||
:: [[Free OXPHOS capacity]], ''โP = P-L''; [[Excess E-P capacity factor |Excess ''E-P'' capacity factor]], ''j<sub>ExP</sub>'' = (''ExP'')/''E'' = 1-''P/E'' | |||
* [[netROUTINE control ratio]], ''โR/E''=(''R-L'')/''E'' | |||
:: [[Free ROUTINE activity]], ''โR = R-L''; [[Excess E-R capacity factor |Excess ''E-R'' capacity factor]], ''j<sub>ExR</sub>'' = (''ExR'')/''E'' = 1-''R/E'' | |||
* ''More details:'' ยป[[ETS coupling efficiency]] | * ''More details:'' ยป[[ETS coupling efficiency]] | ||
== Coupling control ratios related to excess capacities == | |||
* [[OXPHOS control ratio]], ''P/E'' | |||
:: [[Excess E-P capacity |Excess ''E-P'' capacity]], ''ExP = E-P''; [[Excess E-P capacity factor |Excess ''E-P'' capacity factor]], ''j<sub>ExP</sub>'' = (''ExP'')/''E'' = 1-''P/E'' | |||
* [[ROUTINE control ratio]], ''R/E'' | |||
:: [[Excess E-R capacity |Excess ''E-R'' capacity]], ''ExR = E-R''; [[Excess E-R capacity factor |Excess ''E-R'' capacity factor]], ''j<sub>ExR</sub>'' = (''ExR'')/''E'' = 1-''R/E'' | |||
* [[Respiratory acceptor control ratio]] |
Revision as of 15:57, 17 January 2015
Description
Coupling control ratios, CCR, are flux control ratios, FCR, at a constant mitochondrial substrate state. In mitochondrial preparations, there are three well-defined coupling states of respiration, L, P, E (LEAK, OXPHOS, ETS). In intact cells, state P cannot be induced, but a ROUTINE state of respiration, R, can be measured. The reference state, Jref, is defined by taking Jref as the maximum flux, i.e. flux in the ETS state, E, such that the lower and upper limits of CCR are defined as 0.0 and 1.0. Then there are two mitochondrial CCR, L/E and P/E, and two CCR for intact cells, L/E and R/E.
Abbreviation: CCR
Reference: Flux control ratio
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Compare
- ยป Coupling control factor, CCF
- Free OXPHOS capacity, โP = P-L; OXPHOS coupling efficiency, jโP = (โP)/P = 1-L/P
- Free ROUTINE activity, โR = R-L; ROUTINE coupling efficiency, jโR = (โR)/R = 1-L/R
- LEAK control ratio, L/E
- Free ETS capacity, โE = E-L; ETS coupling efficiency, jโE = (โE)/E = 1-L/E
- netOXPHOS control ratio, โP/E=(P-L)/E
- Free OXPHOS capacity, โP = P-L; Excess E-P capacity factor, jExP = (ExP)/E = 1-P/E
- netROUTINE control ratio, โR/E=(R-L)/E
- Free ROUTINE activity, โR = R-L; Excess E-R capacity factor, jExR = (ExR)/E = 1-R/E
- More details: ยปETS coupling efficiency
- OXPHOS control ratio, P/E
- Excess E-P capacity, ExP = E-P; Excess E-P capacity factor, jExP = (ExP)/E = 1-P/E
- Excess E-R capacity, ExR = E-R; Excess E-R capacity factor, jExR = (ExR)/E = 1-R/E