Coupling-control ratio: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=''CCR'' | |abbr=''CCR'' | ||
|description='''Coupling control ratios''', ''CCR'', are [[flux control ratio]]s, ''FCR'', at a constant mitochondrial [[ | |description='''Coupling control ratios''', ''CCR'', are [[flux control ratio]]s, ''FCR'', at a constant mitochondrial [[pathway control state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ET-pathway]]). In intact cells, state ''P'' cannot be induced, but a [[ROUTINE]] state of respiration, ''R'', can be measured. The reference state, ''J''<sub>ref</sub>, is defined by taking ''J''<sub>ref</sub> as the maximum flux, i.e. flux in the ET state, ''E'', such that the lower and upper limits of the ''CCR'' are defined as 0.0 and 1.0. Then there are two mitochondrial ''CCR'', [[L/E|''L/E'']] and [[P/E|''P/E'']], and two ''CCR'' for intact cells, [[L/E|''L/E'']] and [[R/E control ratio|''R/E'']]. | ||
|info=[[Flux control ratio]] | |info=[[Flux control ratio]] | ||
}} | }} |
Revision as of 07:03, 16 July 2019
Description
Coupling control ratios, CCR, are flux control ratios, FCR, at a constant mitochondrial pathway control state. In mitochondrial preparations, there are three well-defined coupling states of respiration, L, P, E (LEAK, OXPHOS, ET-pathway). In intact cells, state P cannot be induced, but a ROUTINE state of respiration, R, can be measured. The reference state, Jref, is defined by taking Jref as the maximum flux, i.e. flux in the ET state, E, such that the lower and upper limits of the CCR are defined as 0.0 and 1.0. Then there are two mitochondrial CCR, L/E and P/E, and two CCR for intact cells, L/E and R/E.
Abbreviation: CCR
Reference: Flux control ratio
MitoPedia concepts:
Respiratory control ratio
MitoPedia methods:
Respirometry
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- Free OXPHOS capacity, โP = P-L
- OXPHOS coupling efficiency, jโP = โP/P = 1-L/P
- Free ROUTINE activity, โR = R-L
- ROUTINE coupling efficiency, jโR = โR/R = 1-L/R
- LEAK control ratio, L/E
- Free ET-capacity, โE = E-L
- ET-coupling efficiency, jโE = โE/E = 1-L/E
- netOXPHOS control ratio, โP/E=(P-L)/E
- Free OXPHOS capacity, โP = P-L
- netROUTINE control ratio, โR/E=(R-L)/E
- Free ROUTINE activity, โR = R-L
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- More details ยป ET-coupling efficiency
- OXPHOS control ratio, P/E
- Excess E-P capacity, ExP = E-P
- Excess E-P capacity factor, jExP = ExP/E = 1-P/E
- Excess E-R capacity, ExR = E-R
- Excess E-R capacity factor, jExR = ExR/E = 1-R/E
Compare
- ยป Coupling control factor, CCF = 1-CCR
- ยป Respiratory acceptor control ratio, RCR