Arena 2018 Mol Cell: Difference between revisions
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{{Publication | {{Publication | ||
|title=Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609. | |title=Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/29452639 PMID: 29452639]; [[File:O2k-brief.png|36px|link=http://wiki.oroboros.at/images/a/a2/Arena_2018_Mol_Cell_O2k-brief.pdf |O2k-brief]] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/29452639 PMID: 29452639 Open Access]; »[[File:O2k-brief.png|36px|link=http://wiki.oroboros.at/images/a/a2/Arena_2018_Mol_Cell_O2k-brief.pdf |O2k-brief]] | ||
|authors=Arena G, Cisse MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombes A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L | |authors=Arena G, Cisse MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombes A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L | ||
|year=2018 | |year=2018 | ||
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|pathways=N, S, NS | |pathways=N, S, NS | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Labels, 2018-03 | |additional=Labels, 2018-03, O2k-brief | ||
}} | }} | ||
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== O2k-brief == | == O2k-brief == | ||
::::» [[ | ::::» [[O2k-brief |List of O2k-Publications presented as O2k-brief]] | ||
Latest revision as of 06:29, 20 April 2020
| Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609. |
» PMID: 29452639 Open Access; »
Arena G, Cisse MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombes A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mol Cell
Abstract: Accumulating evidence indicates that the MDM2 oncoprotein promotes tumorigenesis beyond its canonical negative effects on the p53 tumor suppressor, but these p53-independent functions remain poorly understood. Here, we show that a fraction of endogenous MDM2 is actively imported in mitochondria to control respiration and mitochondrial dynamics independently of p53. Mitochondrial MDM2 represses the transcription of NADH-dehydrogenase 6 (MT-ND6) in vitro and in vivo, impinging on respiratory complex I activity and enhancing mitochondrial ROS production. Recruitment of MDM2 to mitochondria increases during oxidative stress and hypoxia. Accordingly, mice lacking MDM2 in skeletal muscles exhibit higher MT-ND6 levels, enhanced complex I activity, and increased muscular endurance in mild hypoxic conditions. Furthermore, increased mitochondrial MDM2 levels enhance the migratory and invasive properties of cancer cells. Collectively, these data uncover a previously unsuspected function of the MDM2 oncoprotein in mitochondria that play critical roles in skeletal muscle physiology and may contribute to tumor progression. • Keywords: MDM2, MT-ND6, Hypoxia, Migration, Mitochondria, Respiratory complex I • Bioblast editor: Kandolf G • O2k-Network Lab: FR Montpellier Wrutniak-Cabello C
Labels: MiParea: Respiration Pathology: Cancer
Organism: Human Tissue;cell: Lung;gill, Other cell lines Preparation: Permeabilized cells
Coupling state: OXPHOS
Pathway: N, S, NS
HRR: Oxygraph-2k
Labels, 2018-03, O2k-brief
