Noncoupled respiration: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=''E'' | |abbr=''E'' | ||
|description=''' | |description='''Noncoupled respiration''' is distinguished from general (pharmacological or mechanical) [[uncoupled respiration]], to give a label to an effort to reach the fully uncoupled (noncoupled) state without inhibiting respiration. Noncoupled respiration, therefore, yields an estimate of [[ETS]] capacity. Experimentally uncoupled respiration may fail to yield an estimate of ETS capacity, due to inhibition of respiration above [[optimum uncoupler concentration]]s or insufficient stimulation by sub-optimal uncoupler concentrations. '''[[Optimum uncoupler concentration]]s''' for evaluation of (noncoupled) ETS capacity require inhibitor titrations ([[Steinlechner-Maran_1996_AJP]]; [[Huetter_2004_BJ]]; [[Gnaiger_2008_POS]]). | ||
Noncoupled respiration is maximum [[electron flow]] in an open-transmembrane proton circuit mode of operation (see [[ETS capacity]]). | |||
|info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways], [[MitoPedia Glossary: Respiratory states]] | |info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways], [[MitoPedia Glossary: Respiratory states]] | ||
|type=Respiration | |type=Respiration | ||
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|type=Respiration | |type=Respiration | ||
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* Why | * Why noncoupled versus uncoupled? - [[Talk:Uncoupled respiration]] |
Revision as of 09:19, 8 August 2013
Description
Noncoupled respiration is distinguished from general (pharmacological or mechanical) uncoupled respiration, to give a label to an effort to reach the fully uncoupled (noncoupled) state without inhibiting respiration. Noncoupled respiration, therefore, yields an estimate of ETS capacity. Experimentally uncoupled respiration may fail to yield an estimate of ETS capacity, due to inhibition of respiration above optimum uncoupler concentrations or insufficient stimulation by sub-optimal uncoupler concentrations. Optimum uncoupler concentrations for evaluation of (noncoupled) ETS capacity require inhibitor titrations (Steinlechner-Maran_1996_AJP; Huetter_2004_BJ; Gnaiger_2008_POS).
Noncoupled respiration is maximum electron flow in an open-transmembrane proton circuit mode of operation (see ETS capacity).
Abbreviation: E
Reference: Gnaiger 2012 MitoPathways, MitoPedia Glossary: Respiratory states
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
- Why noncoupled versus uncoupled? - Talk:Uncoupled respiration