Bayona-Bafaluy 2021 Redox Biol: Difference between revisions
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Revision as of 01:05, 9 October 2023
Bayona-Bafaluy MP, Garrido-PΓ©rez N, Meade P, Iglesias E, JimΓ©nez-Salvador I, Montoya J, MartΓnez-CuΓ© C, Ruiz-Pesini E (2021) Down syndrome is an oxidative phosphorylation disorder. Redox Biol 41:101871. https://doi.org/10.1016/j.redox.2021.101871 |
Bayona-Bafaluy MP, Garrido-Perez N, Meade P, Iglesias E, Jimenez-Salvador I, Montoya J, Martinez-Cue C, Ruiz-Pesini E (2021) Redox Biol
Abstract: Down syndrome is the most common genomic disorder of intellectual disability and is caused by trisomy of chromosome 21. Several genes in this chromosome repress mitochondrial biogenesis. The goal of this study was to evaluate whether early overexpression of these genes may cause a prenatal impairment of oxidative phosphorylation negatively affecting neurogenesis. Reduction in the mitochondrial energy production and a lower mitochondrial function have been reported in diverse tissues or cell types, and also at any age, including early fetuses, suggesting that a defect in oxidative phosphorylation is an early and general event in Down syndrome individuals. Moreover, many of the medical conditions associated with Down syndrome are also frequently found in patients with oxidative phosphorylation disease. Several drugs that enhance mitochondrial biogenesis are nowadays available and some of them have been already tested in mouse models of Down syndrome restoring neurogenesis and cognitive defects. Because neurogenesis relies on a correct mitochondrial function and critical periods of brain development occur mainly in the prenatal and early neonatal stages, therapeutic approaches intended to improve oxidative phosphorylation should be provided in these periods.
β’ Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities β FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - Β»Bioblast linkΒ«