Template:BioblastAlert2024
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Bioblast alert 2024(02) - Bioenergetics Communications and EBEC2024: 2024-02-15
The tale of two “best-friends,” proteins BID & MTCH2, pivotal regulators of the apoptosis and metabolism programs at the mitochondria.
- Gross A, (2024) A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part? Bioenerg Commun 2024.1. https://doi.org/10.26124/bec:2024-0001
EBEC2024 What is Life? Spotlights on Mito and Chlora:
Cutting-edge research on mitochondria & chloroplasts, metabolism, and disease
2024 August 26-31, Innsbruck, Austria
- »Registration and abstract submission open«
Rewarded Open Access - compensating authors..
Together with the MiPsociety, BEC is raising funds to reward the first 10 papers accepted for publication in BEC in 2024: 600 EUR to attend EBEC2024 and 2-year MiPmembership. -»Support open access in science«
- »Submit a manuscript«
Bioblast alert 2024(01) - Fatty acid oxidation: 2024-02-08
Measuring fatty acid oxidation (FAO)-linked respiration requires a low concentration of malate
In the absence of malate, accumulation of Acetyl-CoA inhibits FAO.
- »Fatty acid oxidation pathway control state«, »Mitochondrial Pathways: Chapter 5«
- communicated by »Cecatto Cristiane« and »Cardoso Luiza«
"The capacity of FA oxidative phosphorylation (F-OXPHOS) with palmitoylcarnitine was up to 4 times higher than respiration with octanoylcarnitine. The optimal concentration of palmitoylcarnitine was 10 μM which corresponds to the total concentration of LC acylcarnitines in the brain."
- Cecatto C, Cardoso LHD, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Gnaiger E, Makrecka-Kuka M, Liepinsh E (2023) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. MitoFit Preprints 2023.10. https://doi.org/10.26124/mitofit:2023-0010
- from the O2k-Network »AT Innsbruck Oroboros« and »LV Riga Liepins E«
"... several graphical representations of the electron transfer system depict FADH2 in the mitochondrial matrix as a substrate to be oxidized by CII. This leads to the false conclusion that FADH2 from the β-oxidation cycle in fatty acid oxidation feeds electrons into CII. In reality, dehydrogenases of fatty acid oxidation channel electrons to the Q-junction but not through CII."
- Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. »Bioblast link«
- from the O2k-Network »AT Innsbruck Oroboros«
"Clinically approved cardiovascular and diabetes drugs reduce LC acylcarnitine concentrations in vivo and it would be worth investigating whether these compounds could be repurposed."
- Dambrova M, Cecatto C, Vilskersts R, Liepinsh E (2022) Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets. Bioenerg Commun 2022.15. https://doi.org/10.26124/bec:2022-0015
- from the O2k-Network »AT Innsbruck Oroboros« and »LV Riga Liepins E«
