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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0ASeveral-20NME-20proteins-20have-20NDP-20kinase-20(NDPK)-20activity-20and-20are-20thus-20a-20major-20source-20of-20cellular-20GTP.-20We-20have-20shown-20that-20mitochondrial-20NME4-20localizing-20to-20the-20intermembrane-20space-20is-20using-20oxidatively-20synthesized-20ATP-20to-20regenerate-20NTPs-20and-20to-20stimulate-20respiration-20by-20the-20generated-20ADP-20-5B1-5D.-20Most-20importantly,-20NME4-20is-20able-20to-20directly-20interact-20with-20and-20fuel-20the-20GTPase-20OPA1,-20thus-20supporting-20OPA1-20functions-20in-20fusion-20and-20remodeling-20of-20the-20inner-20mitochondrial-20membrane-20MIM-20-5B2-5D.-20Both,-20OPA1-20loss-2Dof-2Dfunction-20and-20silencing-20of-20NM23-2DH4,-20result-20in-20fusion-20defects-20that-20manifest-20in-20mitochondrial-20fragmentation-20-5B2-5D.-20We-20also-20identified-20a-20second-20function-20of-20NME4,-20which-20consists-20in-20intermembrane-20cardiolipin-20(CL)-20transfer-20triggered-20by-20pro-2Dmitophagic-20or-20-2Dapoptotic-20stimuli,-20leading-20to-20externalization-20of-20CL-20from-20the-20mitochondrial-20inner-20membrane-20to-20the-20mitochondrial-20surface-20-5B3,4-5D.-20There,-20CL-20acts-20a-20«-20eat-20me-20signal-20»-20for-20mitophagy-20or-20as-20a-20platform-20to-20assemble-20pro-2Dapoptotic-20proteins.-20Our-20most-20recent-20data-20on-20HeLa-20cells-20reveal-20that-20ablating-20either-20of-20the-20two-20NME4-20functions,-20phosphotransfer-20or-20CL-20transfer,-20triggers-20a-20morphogenic-20switch-20that-20leads-20to-20a-20metastasis-2Dlike-20cellular-20phenotype." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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