Search by property

Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0ACardiovascular-20diseases,-20including-20depressed-20cardiac-20function-20in-20aged-2Dinspanidiuals,-20remain-20a-20major-20public-20health-20problem-20in-20all-20over-20the-20world.-20From-20an-20epidemiologic-20perspective,-20attenuation-20of-20cardiovascular-20disease-2Dincidence-20and-20severity-20has-20been-20interested-20largely-20since-20very-20long-20time.-20Clinical-20and-20experimental-20studies-20point-20out-20the-20main-20contribution-20of-20mitochondrial-2Dderived-20reactive-20oxygen-20species,-20ROS,-20as-20an-20important-20candidate-20for-20aged-2Dassociated-20cardiac-20dysfunction.-20Here-20we-20aimed-20to-20determine-20whether-20a-20mitochondria-2Dtargeted-20antioxidant,-20MitoTEMPO,-20could-20preserve-20the-20cardiovascular-20dysfunction-20in-20aged-2Drats-20-27-27in-20vitro-27-27.-20We-20used-20freshly-20isolated-20ventricular-20cardiomyocytes-20from-20male-2024-2Dmonth-20old-20rats-20comparison-20to-20those-20of-206-2Dmonth-20old-20rats.-20Patch-2Dclamp-20examinations-20showed-20that-20the-20prolonged-20action-20potential-20was-20preversed-20with-20mitoTEMPO,-20significantly,-20due-20to-20normalization-20of-20the-20depressed-20voltage-2Ddependent-20K-3Csup-3E+-3C-2Fsup-3E-2Dchannel-20currents.-20The-20mitoTEMPO-20application-20also-20significantly-20attenuated-20the-20activated-20ATP-2Dsensitive-20K-3Csup-3E+-3C-2Fsup-3E-2Dcurrents-20and-20Na-3Csup-3E+-3C-2Fsup-3E-2FK-3Csup-3E+-3C-2Fsup-3E-2Dpump-20currents.-20Furthermore,-20the-20fluorescence-20analysis-20of-20confocal-20images-20exhibited-20that-20the-20intracellular-20levels-20of-20both-20free-20Zn-3Csup-3E2+-3C-2Fsup-3E-20and-20Ca-3Csup-3E2+-3C-2Fsup-3E-20were-20markedly-20normalized-20with-20MitoTEMPO-20treatment-20in-20cardiomyocytes-20from-20aged-2Drats.-20The-20markedly-20increased-20ROS-20level-20in-20aged-2Dcardiomyocytes-20and-20depolarized-20mitochondrial-20membrane-20potential-20could-20be-20preversed-20with-20mitoTEMPO,-20as-20well.-20MitoTEMPO-20also-20maintained-20the-20intracellular-20pH-20level-20in-20these-20senescent-20cells.-20Biochemical-20analysis-20presented-20that-20the-20protein-20expression-20level-20of-20some-20Zn-3Csup-3E2+-3C-2Fsup-3E-2Dtransporters-20localized-20to-20both-20sarcoplasmic-20reticulum-20and-20mictochondria-20and-20responsible-20of-20both-20influx-20of-20Zn-3Csup-3E2+-3C-2Fsup-3E-20into-20cytosol-20and-20cytosolic-20Zn-3Csup-3E2+-3C-2Fsup-3E-2Defflux-20was-20found-20to-20be-20altered,-20due-20to-20alterations-20in-20protein-20expression-20levels-20of-20some-20Zn-3Csup-3E2+-3C-2Fsup-3E-2Dtransporters,-20localized-20to-20sarcolemma-20and-20these-20suborgannels-20in-20cardiomyocytes-20from-20ager-2Drat-20heart.-20Overall,-20our-20present-20data-20from-20aged-2Drats-20demonstrated-20that-20not-20only-20mitochondria-20but-20also-20sarcoplasmic-20reticulum-20and-20the-20associted-20intracellular-20homeostasis-20of-20free-20Zn-3Csup-3E2+-3C-2Fsup-3E,-20at-20most,-20via-20alteration-20in-20Zn-3Csup-3E2+-3C-2Fsup-3E-2Dtransporters-20seem-20to-20be-20good-20candidates-20as-20cardioprotective-2Fcardiotherapeutic-20actors-20in-20cardiomyocytes-20against-20aging-2Dassociated-20alterations-20in-20mammalian-20myocardium." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)