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"Description%2F-27-27%27Additivity-27-27%27-20describes-20the-20princple-20of-20substrate-20control-20of-20mitochondrial-20respiration-20with-20-5B-5Bconvergent-20electron-20flow-5D-5D.-20The-20-27-27%27additive-20effect-20of-20convergent-20electron-20flow-27-27%27-20is-20a-20consequence-20of-20electron-20flow-20converging-20at-20the-20-27-27%27-5B-5BQ-2Djunction-5D-5D-27-27%27-20from-20respiratory-20Complexes-20I-20and-20II-20%28-5B-5BNS-2Dlinked-20substrate-20state-20-7CNS-20or-20CI-3Csmall-3E-26-3C-2Fsmall-3EII-20e-2Dinput-5D-5D%29.-20-20Further-20additivity-20may-20be-20observed-20by-20convergent-20electron-20flow-20through-20-5B-5BGlycerophosphate dehydrogenase complex-7Cglycerophosphate-20dehydrogenase-5D-5D-20and-20-5B-5Belectron-2Dtransferring-20flavoprotein-20complex-5D-5D.-20-20Convergent-20electron-20flow-20corresponds-20to-20the-20operation-20of-20the-20-5B-5BTCA-20cycle-5D-5D-20and-20mitochondrial-20substrate-20supply-20-27-27in-20vivo-27-27.-20Physiological-20substrate-20combinations-20supporting-20convergent-20NS-20e-2Dinput-20are-20required-20for-20reconstitution-20of-20intracellular-20TCA-20cycle-20function.-20-20Convergent-20electron-20flow-20simultaneously-20through-20Complexes-20I-20and-20II-20into-20the-20-5B-5BQ-2Djunction-5D-5D-20supports-20higher-20-5B-5BOXPHOS-2Dcapacity-5D-5D-20and-20-5B-5BET-2Dcapacity-5D-5D-20than-20separate-20electron-20flow-20through-20either-20CI-20or-20CII.-20-20The-20convergent-20-5B-5BNS-5D-5D-20effect-20may-20be-20completely-20or-20partially-20additive%2C-20suggesting-20that-20conventional-20bioenergetic-20protocols-20with-20-5B-5BMitochondrial-20preparations-7Cmt-2Dpreparations-5D-5D-20have-20underestimated-20cellular-20OXPHOS-2Dcapacities%2C-20due-20to-20the-20gating-20effect-20through-20a-20single-20branch.-20Complete-20additivity-20is-20defined-20as-20the-20condition-20when-20the-20sum-20of-20separatly-20measured-20respiratory-20capacities%2C-20N-20%2B-20S%2C-20is-20identical-20to-20the-20capacity-20measured-20in-20the-20state-20with-20combined-20substrates%2C-20NS-20%28CI-3Csmall-3E-26-3C-2Fsmall-3EII%29.-20This-20condition-20of-20complete-20additivity%2C-20NS%3DN%2BS%2C-20would-20be-20obtained-20if-20electron-20channeling-20through-20supercomplex-20CI%2C-20CIII-20and-20CIV-20does-20not-20interact-20with-20the-20pool-20of-20redox-20intermediates-20in-20the-20pathway-20from-20CII-20to-20CIII-20and-20CIV%2C-20and-20if-20the-20capacity-20of-20the-20phosphorylation-20system-20%28%E2%89%88-27-27P-27-27%29-20does-20not-20limit-20OXPHOS-2Dcapacity-20%28-5B-5BExcess-20E-2DP-20capacity-20factor-20-7Cexcess-20-27-27E-2DP-27-27-20capacity-20factor-5D-5D-20is-20zero%29.-20In-20most-20cases%2C-20however%2C-20additivity-20is-20incomplete%2C-20NS-20-3C-20N%2BS" contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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