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• Manfredini 2019 Clin Sci (Lond)
  ...dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clin Sci (Lond) 133:1993-2004. ...al function and long-term cognitive impairment in an experimental model of sepsis.
  3 KB (360 words) - 16:59, 13 May 2020
• Zhang 2018 Mil Med Res
  ...(2018) Potential therapy strategy: targeting mitochondrial dysfunction in sepsis. Mil Med Res 5:41. https://doi.org/10.1186/s40779-018-0187-0 ...etermine the major mitochondrial disorders from morphology to functions in sepsis. In the following, several clinical or pre-clinical assays for monitoring m
  2 KB (289 words) - 11:08, 22 March 2023
• Kohoutova 2019 Crit Care Med
  ...attenuates multiple organ dysfunction in resuscitated porcine progressive sepsis. Crit Care Med 47:e461-69. ...rve stimulation in a clinically-relevant large animal model of progressive sepsis.
  3 KB (355 words) - 19:42, 17 February 2022
• Volt 2014 Abstract The 2014 Ageing Summit
  ...in on the age-dependent dysregulation of the Nf-Kb/Nlrp3 activation during sepsis. ...s support NLRP3 inflammasome as a novel molecular signaling pathway during sepsis and indentify it as a main target for the anti-inflammatory action of melat
  2 KB (288 words) - 17:34, 7 November 2016
• Cheng 2016 Nat Immunol
  ...defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13. ...suggested that metabolic processes might represent a therapeutic target in sepsis.
  2 KB (303 words) - 04:13, 12 February 2020
• Weiss 2021 Crit Care Explor
  ..., Collman RG (2021) Decreased intestinal microbiome diversity in pediatric sepsis: a conceptual framework for intestinal dysbiosis to influence immunometabol ...ain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty acids in plasma and
  3 KB (418 words) - 09:31, 9 July 2021
• Loftus 2017 BMJ Open
  ...tocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients. BMJ Open 7:e015136. ...istent inflammation, immunosuppression and catabolism syndrome (PICS). The Sepsis and Critical Illness Research Center (SCIRC) was created to provide a platf
  3 KB (386 words) - 17:40, 27 November 2017
• Jang 2016 J Intensive Care Med
  ...2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94. ...l utility. Treatment of commonly encountered disease of acute care such as sepsis, trauma, and poisoning often relies on clinical diagnosis and therapy guide
  2 KB (252 words) - 23:26, 29 February 2020
• Lancel 2009 J Pharmacol Exp Ther
  ...B, Motterlini R, Neviere R (2009) Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondri ...) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects. The ro
  3 KB (359 words) - 11:49, 22 December 2020
• Hara 2013 Eur J Anaesthesiol
  ...Uchino H (2013) Early brain mitochondrial dysfunction in a mouse model of sepsis: 7AP4‐9. Eur J Anaesthesiol 30,112-112. ...the temporal dynamics of brain mitochondrial function in a mouse model of sepsis.
  3 KB (428 words) - 13:45, 7 March 2020
• Weiss 2022 J Cell Mol Med
  ...gh which butyrate may help to mitigate the immuno-inflammatory response in sepsis. |keywords=Human immunology, Immunometabolism, Metabolism, Mitochondria, Sepsis
  2 KB (275 words) - 14:13, 28 November 2022
• Luther 2023 Am J Physiol Renal Physiol
  ...A, Frithiof R (2023) Renal mitochondrial dysfunction in ovine experimental sepsis associated acute kidney injury. https://doi.org/10.1152/ajprenal.00294.2022 ...of experiment and assessed ''in vitro'' with high resolution respirometry. Sepsis markedly reduced creatinine clearance and the relation between sodium trans
  3 KB (383 words) - 16:36, 2 May 2023
• Rutai 2019 Crit Care
  ...019) Potential role of endothelin receptors in the therapy of experimental sepsis. Crit Care. ...microcirculatory and mitochondrial respiration parameters in experimental sepsis.
  3 KB (365 words) - 14:50, 3 April 2019
• Karlsson 2016 Shock
  ...and tissue-specific mitochondrial respiratory response in a mouse model of sepsis-induced multiple organ failure. Shock 45:404-10. ...ggests a diverse and tissue-specific mitochondrial respiratory response to sepsis. The brain displayed an early impaired mitochondrial respiratory efficiency
  2 KB (351 words) - 13:40, 7 March 2020
• Preau 2014 Thesis University Lille
  ...yocardial dysfunction. Septic cardiomyopathy appears in the early phase of sepsis and is associated with fatal outcome. Complete recovery of myocardial funct sepsis that is suggested to postpone myocardium recovery. The first aim of the stu
  2 KB (291 words) - 09:51, 8 November 2016
• Wu 2023 Int Immunopharmacol
  |title=Wu F, Zhang YT, Teng F, Li HH, Guo SB (2023) S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fis ...a9 may be a promising therapeutic strategy to prevent SIC in patients with sepsis.
  3 KB (372 words) - 17:08, 19 January 2023
• Sjoevall 2014 PLoS One
  ...Magnus J, Elmer E (2014) Cytokine and nitric oxide levels in patients with sepsis - temporal evolvement and relation to platelet mitochondrial respiratory fu ...d anti-inflammatory cytokines as well as NO plasma levels in patients with sepsis.
  3 KB (400 words) - 12:22, 16 September 2021
• MacMillan-Crow 2018 Intern Med Rev (Wash D C)
  ...ndrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C) 4. ...in females. Our results suggest that the CLP nephrectomy comorbid model of sepsis may be an appropriate model to study gender differences a select group of p
  2 KB (354 words) - 11:35, 8 August 2019
• Halbach 2019 Am J Physiol Regul Integr Comp Physiol
  ...19) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168. ...after exposure to HBOT. Early HBOT could be of benefit in the treatment of sepsis and the protective mechanism may be related to a reduction in the systemic
  2 KB (378 words) - 12:25, 9 July 2019
• Sjoevall 2010 Crit Care
  ...espiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14:R214. ...al changes in platelet mitochondrial respiratory function in patients with sepsis during the first week after disease onset.
  3 KB (486 words) - 13:22, 27 December 2021

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