Song 2020 Life Sci: Difference between revisions
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|title=Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci [Epub ahead of print]. | |title=Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci [Epub ahead of print]. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/32289432 PMID: 32289432] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/32289432 PMID: 32289432] | ||
|authors=Song | |authors=Song Kang, Zhang Yifan, Ga Qin, Bai Zhenzhong, Ge Ri-Li | ||
|year=2020 | |year=2020 | ||
|journal=Life Sci | |journal=Life Sci | ||
Revision as of 14:30, 15 April 2020
| Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci [Epub ahead of print]. |
Song Kang, Zhang Yifan, Ga Qin, Bai Zhenzhong, Ge Ri-Li (2020) Life Sci
Abstract: High-fat intake induces obesity and non-alcoholic fatty liver disease (NAFLD). However, high-altitude chronic hypoxia might alleviate NAFLD progression through improved mitochondrial function and AMP-activated protein kinase (AMPK) signaling. We hypothesized that high-altitude chronic hypoxia would have protective effects against NAFLD development.
C57BL/6J mice were randomly divided into control (normal diet and altitude 50 m), CHH (normal diet and altitude 4300 m), HFD (high-fat diet and altitude 50 m), and HFD-CHH (high-fat diet and altitude 4300 m) groups. After being maintained for 8 weeks under the appropriate conditions, mice were evaluated.
The degree of liver lipid accumulation and expression of the lipid synthesis-related genes acetyl-CoA carboxylase1 (ACC1), fatty acid synthesis (FAS), and sterol regulatory element binding protein-1c (SREBP-1c) were reduced in the HFD-CHH group; however, expression of the lipolysis-related gene carnitine palmitoyl transferase 1 (CPT1) was increased. Furthermore, in addition to increased expression of mitochondrial biogenesis-related genes, mitochondrial respiratory function and mitochondrial DNA content were elevated in the HFD-CHH group compared to those in the HFD group. The HFD-CHH group also exhibited significantly increased antioxidation activity and decreased reactive oxygen species production (P < 0.05). Finally, AMPK signaling in the liver was activated and the expression of phosphorylated-AMPK (P-AMPK) was significantly increased in the HFD-CHH group.
Collectively, our findings suggest that high altitude-induced hypoxia might improve impaired mitochondrial function and activate AMPK signaling in obesity-induced NAFLD. High-altitude chronic hypoxia could be a new treatment strategy for obesity-induced NAFLD.
Copyright © 2018. Published by Elsevier Inc. • Keywords: AMPK, Chronic hypoxia, High altitude, Mitochondria, NAFLD, Obesity • Bioblast editor: Plangger M
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2020-04
