Difference between revisions of "Rotenone"
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(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9 dimethoxychromeno[3,4-b]furo(2,3-h)chromen-6-on; Inhibitor of complex I via inhibition of NADH oxidation.It inhibits the transfer of electrons from iron-sulfur centers in CI to ubiquinone via binding to the ubiquinone binding site of CI. Β | {{MitoPedia | ||
= | |abbr=Rot | ||
|description=(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9 dimethoxychromeno[3,4-b]furo(2,3-h)chromen-6-on; Inhibitor of [[complex I]] via inhibition of NADH oxidation.It inhibits the transfer of electrons from iron-sulfur centers in CI to ubiquinone via binding to the ubiquinone binding site of CI. Β | |||
Β | |info=MiPNet11.09, MiPNet09.12, MiPNet12.15 | ||
{{ | |type=Inhibitor ETS | ||
}} | |||
{{Labeling | |||
|instruments=Chemicals; Media | |||
|discipline=Mitochondrial Physiology | |||
|kinetics=Inhibitor; Uncoupler | |||
|enzymes=Complex I | |||
}} |
Revision as of 15:17, 15 September 2010
Description
(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9 dimethoxychromeno[3,4-b]furo(2,3-h)chromen-6-on; Inhibitor of complex I via inhibition of NADH oxidation.It inhibits the transfer of electrons from iron-sulfur centers in CI to ubiquinone via binding to the ubiquinone binding site of CI.
Abbreviation: Rot
Reference: MiPNet11.09, MiPNet09.12, MiPNet12.15
Labels:
Enzyme: Complex I
HRR: Chemicals; Media"Chemicals; Media" is not in the list (Oxygraph-2k, TIP2k, O2k-Fluorometer, pH, NO, TPP, Ca, O2k-Spectrophotometer, O2k-Manual, O2k-Protocol, ...) of allowed values for the "Instrument and method" property.