Correa 2012 Mitochondrion: Difference between revisions
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|couplingstates=LEAK, OXPHOS, ETS | |couplingstates=LEAK, OXPHOS, ETS | ||
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Revision as of 16:06, 7 November 2016
Correa CC, Aw WC, Melvin RG, Pichaud N, Ballard JWO (2012) Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster. Mitochondrion 12:459-64. |
Correa CC, Aw WC, Melvin RG, Pichaud N, Ballard JWO (2012) Mitochondrion
Abstract: The influence of mitochondrial DNA (mtDNA) mutations on human disease has been extensively studied, but the impact of mutations within the adaptive range is debated. We studied males from lines of Drosophila melanogaster that have a highly standardized nuclear genome but different mtDNA, at two ages. We measured mitochondrial respiration on permeabilized muscle fibers, hydrogen peroxide production of isolated mitochondria and mtDNA copy number of whole individuals. The results show that a small set of naturally occurring mtDNA mutations can have a significant influence on mitochondrial bioenergetics that may change as the organism Ages. โข Keywords: Mitochondrial bioenergetics, Reactive oxygen species, mtDNA copy number
โข O2k-Network Lab: AU Sydney Ballard JW
Labels: MiParea: Respiration, mtDNA;mt-genetics, Comparative MiP;environmental MiP
Pathology: Aging;senescence
Organism: Drosophila Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue, Isolated mitochondria
Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
Pathway: N, S, ROX
HRR: Oxygraph-2k