Template:SUIT F(N): Difference between revisions
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Respiratory stimulation of the [[Fatty acid oxidation pathway control state| FAO-pathway]], F, by [[fatty acid]], FA, in the presence of [[malate]], M. Malate is a [[NADH Electron transfer-pathway state |type N substrate]] (N), required for the [[Fatty acid oxidation pathway control state| FAO-pathway]]. In the presence of [[Malate anaplerotic pathway control state|anaplerotic pathways]] ( | Respiratory stimulation of the [[Fatty acid oxidation pathway control state| FAO-pathway]], F, by [[fatty acid]], FA, in the presence of [[malate]], M. Malate is a [[NADH Electron transfer-pathway state |type N substrate]] (N), required for the [[Fatty acid oxidation pathway control state| FAO-pathway]]. In the presence of [[Malate anaplerotic pathway control state|anaplerotic pathways]] (''e.g.'', [[Malic enzyme|mitochondrial malic enzyme, mtME]]) FAO-pathway could be overestimated due to a contribution of NADH-linked respiration, F(N) (see [[SUIT-002]]). The FA concentration has to be optimized to saturate the [[Fatty acid oxidation pathway control state| FAO-pathway]], without inhibiting or uncoupling respiration. | ||
Revision as of 09:39, 12 March 2019
Respiratory stimulation of the FAO-pathway, F, by fatty acid, FA, in the presence of malate, M. Malate is a type N substrate (N), required for the FAO-pathway. In the presence of anaplerotic pathways (e.g., mitochondrial malic enzyme, mtME) FAO-pathway could be overestimated due to a contribution of NADH-linked respiration, F(N) (see SUIT-002). The FA concentration has to be optimized to saturate the FAO-pathway, without inhibiting or uncoupling respiration.
