Viruses and mitochondrial medicine

From Bioblast

high-resolution terminology - matching measurements at high-resolution

Viruses and mitochondrial medicine


Not enough is known about viruses and mitochondrial medicine, although several studies point towards a link between viral infection and mitochondrial dysfunction using high-resolution respirometry, with potential impact on drug development.

Abbreviation: Virus-mt-Medicine

Communicated by Gnaiger E 2020-02-23, last update 2020-05-05
Gentle Science

The world of humankind is and will be different during and after the COVID-19 crisis – a fact beyond our competence. How different the world will be – depends on our ability to learn and communicate.

Obesity and COVID-19 severity

Since the decline of mitochondrial respiratory function is strongly associated with obesity (mitObesity), health practitioners have to be made aware of the potential role played by obesity and mitochondrial dysfunction in determining COVID-19 severity.
  1. Petrilli Christopher M, Jones Simon A, Yang Jie, Rajagopalan Harish, O'Donnell Luke F, Chernyak Yelena, Tobin Katie, Cerfolio Robert J, Francois Fritz, Horwitz Leora I (2020) Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv doi: . - »Bioblast link«
  2. Bhatraju Pavan K, Ghassemieh Bijan J, Nichols Michelle, Kim Richard, Jerome Keith R, Nalla Arun K, Greninger Alexander L, Pipavath Sudhakar, Wurfel Mark M, Evans Laura, Kritek Patricia A, West T Eoin, Luks Andrew, Gerbino Anthony, Dale Chris R, Goldman Jason D, O’Mahony Shane, Mikacenic Carmen (2020) Covid-19 in critically ill patients in the Seattle region - case series. N Engl J Med 2020;NEJMoa2004500 [published online ahead of print, 2020 Mar 30]. - »Bioblast link«
  3. Qingxian Cai, Chen Fengjuan, Fang Luo, Xiaohui Liu, Tao Wang, Qikai Wu, Qing He, Zhaoqin Wang, Yingxia Liu, Jun Chen, Lei Liu, Lin Xu (2020) Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Lancet Preprint at SSRN - »Bioblast link«
  4. Stefan N, Birkenfeld AL, Schulze MB, Ludwig DS (2020) Obesity and impaired metabolic health in patients with COVID-19. Nat Rev Endocrinol 2020:1‐2 [published online ahead of print, 2020 Apr 23]. - »Bioblast link«

News: Coronavirus - COVID-19 or 2019-nCoV

Manifesto for EU COVID-19 Research On September 29, 2020, as a Horizon 2020 beneficiary, Oroboros signed the Manifesto for EU COVID-19 Research, showing our support for the accessibility of research results in the fight against COVID-19.

From the European Commission - On the May 4, 2020, the European Union and its partners launched a coronavirus global response campaign, with the goal to raise €7.5bn to develop diagnostics, treatments and vaccines and deploy them to every corner of the world at an affordable price.

Key messages of the campaign:

  • To fight the coronavirus, the world urgently needs effective and safe diagnostics, treatments and vaccines - without these we ALL remain vulnerable.
  • The European Commission has made a significant contribution to the Coronavirus Global Response pledge with €1 billion mobilised by Horizon 2020
  • Together, we are stronger: EU research and innovation brings Europe’s leading scientists and innovators together to coordinate efforts across the EU and beyond to tackle the coronavirus crisis
  • The crisis requires a response of unprecedented scale, speed and solidarity - the global research and innovation community is already mobilised but we need to do more
  • We are committed to continuing to support our researchers and innovators in these critical times



»WHO Coronavirus disease (COVID-2019) situation reports«
  • 2020-03-11* WHO declares COVID-19 a pandemic - why so late? See »JAMA 2020-03-03«
  • 2020-04-30: The number of COVID-19 cases surpassed 3 Mill globally (1 Mill US). | 2020-04-23: WHO Director-General Dr. Tedros cautioned that “we have a long way to go. This virus will be with us for a long time”.

WHO-COVID-19-dynamics.jpg WHO-COVID-19-dynamics 2.jpg

  • Sharing data and perspectives - Preprints
  • 2020-03-24: Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. MitoFit Preprint Arch doi:10.26124/mitofit:200001. - »Bioblast link«
  • Stay fit
  • 2020-03-21 WHO EURO has released a guide on how to stay physically active during self-quarantine. Information can be found »here«.
  • COVID-19 at PMC
» All publications listed in PMC «
  • "And this global political crisis isn't over yet. It has barely begun."
2020-03-21: "Too few people paid attention to China's well documented clinical experience. The present outcome was all too plain to predict." - Horton Richard (2020) Offline: COVID-19—a reckoning. Lancet 10228: P935, March 21, 2020. - »Open Access«
2020-03-11: "Had China allowed physician Li Wenliang and his brave Wuhan colleagues to convey their suspicions regarding a new form of infectious pneumonia to colleagues, social media, and journalists without risking sanction, and had local officials not for weeks released false epidemic information to the world, we might not now be facing a pandemic. .. And had the Trump administration not declared criticism of its slow response to the encroaching epidemic a “hoax”, claiming it was a political attack from the left, the US CDC might have been pressured to do widespread testing in early February, discovering pockets of community transmission before they dispersed widely." - Garrett Laurie (2020) COVID-19: the medium is the message. Lancet 10228:P942-3, March 21, 2020. - »Open Access«

  • Official H2020 position
Published on : 16-03-2020 4:52 PM
FAQ ID : 12945
Article 51 of the H2020 MGA sets out the conditions in which the force majeure clause can be used. ‘Force majeure’ relates to an extraordinary and unforeseeable event or situation that is beyond the beneficiaries control and that prevents them from fulfilling their obligations under the action.
If such a situation occurs, beneficiaries must immediately inform the Commission/Agency/Funding Body, which will examine on a case-by-case basis the possible application of the rules on force majeure. Moreover, beneficiaries must immediately take all the necessary steps to limit any damage due to force majeure (e.g. try to cancel the flight ticket, claim the reimbursement from the cancellation insurance (if applicable)).
Costs will be eligible, if they fulfil the general eligibility conditions set out in Article 6 H2020 MGA like any other costs incurred under the action. For example, if a meeting/event cannot take place due to force majeure, travel and accommodation costs may still be charged to the H2020 action if they fulfil the cost eligibility conditions, even if the beneficiary did not travel and did not take part in the meeting/event. If force majeure entails extra costs for the implementation of the action, these costs may be eligible if necessary for the implementation for the action (e.g. a cancelled conference is reorganised at a later stage). However, the maximum grant amount cannot be increased.

"Given the continual spread of COVID-19 around the world, understanding the action items that were implemented quickly in Taiwan and assessing the effectiveness of these actions in preventing a large-scale epidemic may be instructive for other countries." - Wang C Jason, Ng Chun Y, Brook Robert H (2020) Response to COVID-19 in Taiwan. Big data analytics, new technology, and proactive testing. JAMA. Published online March 3, 2020. - »Open Access«

2020-03-10 Corona virus - University of Innsbruck: beginning with March 10, no lectures will take place on the university premises
  • 2019-nCoV (WHO), SARS-CoV-2 (International Committee on Taxonomy of Viruses)

»Previous communications«

Publications: Viruses and mt-medicine

Brown 2020 BMJ2020Brown Robert A, Rhein Helga M, Alipio Mark M, Annweiler Cedric, Gnaiger Erich, Holick Michael F, Boucher Barbara J, Duque Gustavo, Féron François, Kenny Rose Anne, Montero-Odasso Manuel, Minisola Salvatore, Rhodes Jonathan, Haq Afrozul, Bejerot Susanne, Reiss Lina AJ, Zgaga Lina, Crawford Michael A, Fricker Rosemary A, Cobbold Peter, Lahore Henry W, Humble Mats B, Sarkar Amrita, Karras Spiros, Iglesias-Gonzalez Javier, Gezen-Ak Duygu, Dursun Erdinc, Cooper Isabella, Grimes David, de Voil Cedric WB (2020) COVID-19 ’ICU’ risk – 20-fold greater in the vitamin D deficient. BAME, African Americans, the older, institutionalised and obese, are at greatest risk. Sun and ‘D’-supplementation – game-changers? Research urgently required.;gill
Brown 2020 MitoFit Preprint Arch2020Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research.
Ledur 2020 Sci Rep2020Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.HumanNervous system
Weinstein 2019 bioRxiv2019Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: .HumanOther cell lines
Du 2019 J Virol2019Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19.HorseBlood cells
Other cell lines
Cell death
Braz-De-Melo 2019 Sci Rep2019Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119.HumanNeuroblastoma
Fernandes-Siqueira 2018 mSphere2018Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.HumanLiver
Other cell lines
Qu 2018 FASEB J2018Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.HumanLiver
Wang 2018 Mol Med Rep2018Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26.
Xia 2016 RSC Adv2016Xia Z, Yi X, Zhuang Y (2016) Stable over-expression of the human malate–aspartate NADH shuttle member Aralar I in PK15 cells improves energy metabolism and enhances proliferation of porcine circovirus-2. RSC Adv 6:61268-77.PigKidney
Silva 2012 PLOS ONE2012Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2012) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death. PLoS One 7:e33871.MouseNeuroblastomaMitochondrial disease
El-Bacha 2012 Int J Biochem Cell Biol2012El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6.Human
Nervous system
Oxidative stress;RONS
Morse 2012 J Infect Dis2012Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang da W, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA (2012) HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue. J Infect Dis 205:1778-1787.HumanSkeletal muscle
Blood cells
Mutuel 2010 Virology2010Mutuel D, Ravallec M, Chabi B, Multeau C, Salmon JM, Fournier P, Ogliastro M (2010) Pathogenesis of Junonia coenia densovirus in Spodoptera frugiperda: a route of infection that leads to hypoxia. Virology 403:137-44.HexapodsIschemia-reperfusion
Oxidative stress;RONS
El-Bacha 2007 Biochim Biophys Acta2007El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT (2007) Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus. Biochim Biophys Acta 1772:1158-66.HumanLiverCell death
Yuan 2006 Mol Cells2006Yuan X, Shan Y, Yao Z, Li J, Zhao Z, Chen J, Cong Y (2006) Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein. Mol Cells 21:186–91.HumanCell death
Vrbacky 2003 Physiol Res2003Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.Human
Other mammals
Endothelial;epithelial;mesothelial cell
Other cell lines
Cell death

MitoPedia concepts: MiP concept 

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