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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Larsen Steen
MitoPedia topics: EAGLE
COST: Member COST WG1: WG1 COST WG2: WG2
Name | Larsen Steen, Assistant Professor, DMSci. |
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Institution | University of Copenhagen
Faculty Of Health Sciences Center for Healthy Aging Department of Biomedical Sciences |
Address | Blegdamsvej 3B, building 12.4, 2200 |
City | Copenhagen |
State/Province | |
Country | Denmark |
[email protected] | |
Weblink | |
O2k-Network Lab | DK Copenhagen Dela F, DK Copenhagen Larsen S |
Bioenergetics Communications
- Steen Larsen is Associate Editor of the journal Bioenergetics Communications
- Keywords: exercise, humans, skeletal muscle, mitochondria, lipid metabolism
MitoEAGLE Feedback
- Congratulations with the funding. We would like to participate in the MitoEAGLE network. I would also be interested in joining some of the WP, if you need it. - Steen Larsen (2016).
Participated at
- MiP2023 Obergurgl AT
- Mitochondrial Physiology ‐ from Organelle to Organism 2019 Copenhagen DK
- MitoEAGLE 2019 Obergurgl AT
- MitoEAGLE 2018 Copenhagen DK
- MitoEAGLE 2017 Hradec Kralove CZ
- IOC95 Obergurgl AT
- MiP2014 Obergurgl AT
- MiPschool 2013 Copenhagen DK
- MiP2013 Obergurgl AT
- IOC74 Innsbruck AT
- IOC61 Schroecken AT
- IOC39 Schroecken AT
Labels:
Publications
Published | Reference | |
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Doerrier 2024 Free Radic Biol Med | 2024 | Doerrier C, Gama-Perez P, Pesta D, Distefano G, Soendergaard SD, Maise Chroeis K, Gonzalez-Franquesa A, Goodpaster BH, Prats C, Sales-Pardo M, Guimera R, Coen PM, Gnaiger E, Larsen S, Garcia-Roves PM (2024) Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. Free Radic Biol Med 223:384-97. https://doi.org/10.1016/j.freeradbiomed.2024.07.039 |
Correia 2023 Endocrinology | 2023 | Correia CM, Præstholm SM, Havelund JF, Pedersen FB, Siersbæk MS, Ebbesen MF, Gerhart-Hines Z, Heeren J, Brewer J, Larsen S, Blagoev B, Færgeman NJ, Grøntved L (2023) Acute deletion of the glucocorticoid receptor in hepatocytes disrupts postprandial lipid metabolism in male mice. Endocrinology 164:bqad128. https://doi.org/10.1210/endocr/bqad128 |
Bellissimo 2023 BEC | 2023 | Bellissimo CA, Soendergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2023) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition in permeabilized skeletal muscle fibers. Bioenerg Commun 2023.1. https://doi.org/10.26124/bec:2023-0001 |
Damgaard 2022 iScience | 2022 | Damgaard MV, Nielsen TS, Basse AL, Chubanava S, Trost K, Moritz T, Dellinger RW, Larsen S, Treebak JT (2022) Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity. iScience 25:103863. https://doi.org/10.1016/j.isci.2022.103863 |
Pedersen 2022 Nat Commun | 2022 | Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nat Commun 13:2931. https://doi.org/10.1038/s41467-022-30629-5 |
Dall 2021 J Biol Chem | 2021 | Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT (2021) Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. J Biol Chem 297:101388. |
Szczerbinski 2021 Cells | 2021 | Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013. |
Sahl 2021 Adipocyte | 2021 | Sahl RE, Høy Helms EF, Schmücker M, Flensted-Jensen M, Ingersen A, Morville T, Dela F, Helge JW, Larsen S (2021) Reliability and variation in mitochondrial respiration in human adipose tissue. Adipocyte 10:605-11. |
Flensted-Jensen 2021 Free Radic Biol Med | 2021 | Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H2O2 emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6. |
Basse 2021 Mol Metab | 2021 | Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Oertenblad N, Altıntas A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Moeller AB, Karlsen A, Kjaer M, Barres R, Vissing J, Larsen S, Jessen N, Treebak JT (2021) Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity. Mol Metab 53:101271. |
Mendham 2021 Diabetologia | 2021 | Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59. |
Christiansen 2021 Sci Rep | 2021 | Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167. |
Nicolaisen 2020 FASEB J | 2020 | Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91. |
Mendham 2020 Sci Rep | 2020 | Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785. |
MitoEAGLE muscle 1 | 2020 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08 |
BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
Jespersen 2020 Sci Rep | 2020 | Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344. |
Hingst 2020 Mol Metab | 2020 | Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028. |
Chroeis 2019 Basic Clin Pharmacol Toxicol | 2019 | Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. https://doi.org/10.1111/bcpt.13304 |
Dollerup 2019 J Physiol | 2019 | Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54. |
Dall 2019 J Biol Chem | 2019 | Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26. |
Chroeis 2019 Eur J Sport Sci | 2019 | Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45. |
Wiberg 2019 Eur Heart J Acute Cardiovasc Care | 2019 | Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 9:S138-44. |
Larsen 2019 Appl Physiol Nutr Metab | 2019 | Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64. |
Dandanell 2018 Scand J Med Sci Sports | 2018 | Dandanell S, Meinild-Lundby AK, Andersen AB, Lang PF, Oberholzer L, Keiser S, Robach P, Larsen S, Rønnestad BR, Lundby C (2018) Determinants of maximal whole-body fat oxidation in elite cross-country skiers: role of skeletal muscle mitochondria. Scand J Med Sci Sports 28:2494-504. |
Dela 2018 Acta Physiol (Oxf) | 2018 | Dela F, Ingersen A, Andersen NB, Nielsen MB, Petersen HHH, Hansen CN, Larsen S, Wojtaszewski J, Helge JW (2018) Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes. Acta Physiol (Oxf) 226:e13245. |
Dohlmann 2018 Physiol Rep | 2018 | Dohlmann TL, Hindsø M, Dela F, Helge JW, Larsen S (2018) High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle. Physiol Rep 6:e13857. |
Larsen 2018 Physiol Rep | 2018 | Larsen S, Lundby AM, Dandanell S, Oberholzer L, Keiser S, Andersen AB, Haider T, Lundby C (2018) Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males. Physiol Rep 6:e13793. |
Sahl 2018 Anal Biochem | 2018 | Sahl RE, Morville T, Kraunsøe R, Dela F, Helge JW, Larsen S (2018) Variation in mitochondrial respiratory capacity and myosin heavy chain composition in repeated muscle biopsies. Anal Biochem 556:119-24. |
Lund 2018 Acta Physiol (Oxf) | 2018 | Lund MT, Larsen S, Hansen M, Courraud J, Floyd AK, Støckel M, Helge JW, Dela F (2018) Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery. Acta Physiol (Oxf) 223:e13032. |
Meinild Lundby 2018 Acta Physiol (Oxf) | 2018 | Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C (2018) Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta Physiol (Oxf) 222, e12905. |
Thomsen 2017 Neurobiol Aging | 2017 | Thomsen K, Yokota T, Hasan-Olive MM, Sherazi N, Fakouri NB, Desler C, Regnell CE, Larsen S, Rasmussen LJ, Dela F, Bergersen LH, Lauritzen M (2017) Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus. Neurobiol Aging 61:215-24. |
Asping 2017 Eur J Clin Pharmacol | 2017 | Asping M, Stride N, Søgaard D, Dohlmann TL, Helge JW, Dela F, Larsen S (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. Eur J Clin Pharmacol 73:679-87. |
Soendergaard 2016 Eur J Sport Sci | 2016 | Søndergård SD, Dela F, Helge JW, Larsen S (2016) Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle. Eur J Sport Sci 16:801-7. |
Larsen 2015 Physiol Rep | 2015 | Larsen S, Scheede-Bergdahl C, Whitesell T, Boushel R, Bergdahl A (2015) Increased intrinsic mitochondrial respiratory capacity in skeletal muscle from rats with streptozotocin-induced hyperglycemia. Physiol Rep 3 pii:e12467. |
Dahl 2015 Acta Physiol (Oxf) | 2015 | Dahl R, Larsen S, Dohlmann TL, Qvortrup K, Helge JW, Dela F, Prats C (2015) Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization. Acta Physiol (Oxf) 213:145-55. |
Larsen 2014 Biochim Biophys Acta | 2014 | Larsen S, Díez-Sánchez C, Rabøl R, Royo IA, Dela F, Helge JW (2014) Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. Biochim Biophys Acta 1837:226-31. |
Larsen 2014 Anal Biochem | 2014 | Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F (2014) The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry? Anal Biochem 446:64-8. |
Larsen 2014 World J Diabetes | 2014 | Larsen S, Skaaby S, Helge JW, Dela F (2014) Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World J Diabetes 5:482-92. |
Stride 2013 Eur J Heart Fail | 2013 | Stride N, Larsen S, Hey-Mogensen M, Sander K, Lund JT, Gustafsson F, Kober L, Dela F (2013) Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. Eur J Heart Fail 15:150-7. |
Kristensen 2013 PLoS One | 2013 | Kristensen JM, Larsen S, Helge JW, Dela F, Wojtaszewski JFP (2013) Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS One 8:e53533. |
Larsen 2013 J Am Coll Cardiol | 2013 | Larsen S, Stride N, Hey-Mogensen M, Hansen CN, Bang LE, Bundgaard H, Nielsen LB, Helge JW, Dela F (2013) Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. J Am Coll Cardiol 61:44-53. |
Larsen 2012 J Physiol | 2012 | Larsen S, Nielsen J, Neigaard Nielsen C, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel RC, Helge JW, Dela F, Hey-Mogensen M (2012) Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol 590:3349-60. |
Stride 2012 Front Physiol | 2012 | Stride N, Larsen S, Treebak JT, Hansen CN, Hey-Mogensen M, Speerschneider T, Jensen TE, Jeppesen J, Wojtaszewski JF, Richter EA, Køber L, Dela F (2012) 5'-AMP activated protein kinase is involved in the regulation of myocardial β-oxidative capacity in mice. Front Physiol 3:33. |
Larsen 2012 CryoLetters | 2012 | Larsen S, Wright-Paradis C, Gnaiger E, Helge JW, Boushel RC (2012) Cryopreservation of human skeletal muscle impairs mitochondrial function. Cryo Letters 33:170-6. |
Larsen 2012 Acta Physiol (Oxf) | 2012 | Larsen S, Hey-Mogensen M, Raboel R, Stride N, Helge JW, Dela F (2012) The influence of age and aerobic fitness: Effects on mitochondrial respiration in skeletal muscle. Acta Physiol (Oxf) 205:423-32. |
Ara 2011 Int J Obes | 2011 | Ara I, Larsen S, Stallknecht B, Guerra B, Morales-Alamo D, Andersen JL, Ponce-González JG, Guadalupe-Grau A, Galbo H, Calbet JA, Helge JW (2011) Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans. Int J Obes 35: 99-108. |
Larsen 2011 Acta Physiol (Oxf) | 2011 | Larsen S, Kristensen JM, Stride N, Wojtaszewski JF, Helge JW, Dela F (2011) Skeletal muscle mitochondrial respiration in AMPKα2 kinase-dead mice. Acta Physiol (Oxf) 205: 314-320. |
Larsen 2011 Diabetologia | 2011 | Larsen S, Stride N, Hey-Mogensen M, Hansen CN, Andersen JL, Madsbad S, Worm D, Helge JW, Dela F (2011) Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. Diabetologia 54: 1427-1436. |
Raboel 2010 J Clin Endocrinol Metab | 2010 | Raboel R, Larsen S, Hojberg PM, Almdal T, Boushel RC, Haugaard SB, Andersen JL, Madsbad S, Dela F (2010) Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity. J Clin Endocrinol Metab 95:857-63. |
Larsen 2009 Diabetologia | 2009 | Larsen S, Ara I, Rabøl R, Andersen JL, Boushel RC, Dela F, Helge JW (2009) Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes? Diabetologia 52:1400-8. |
Abstracts
Published | Reference | |
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Larsen 2023 MiP2023 | 2023 | Mitochondrial adaptations to weight loss – lifestyle, surgery or medication. |
Doerrier 2020 PaduaMuscleDays Poster | 2020 | Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays. |
Doerrier 2019 MiP2019 | 2019 | Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. |
Doerrier 2018 MiP2018c | 2018 | Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation. |
Coen 2017 MiP2017 WG2 | 2017 | Human skeletal muscle mitochondrial function: A proposal for a state-of-the-art literature review. |
Larsen 2017 MiP2017 WG2 | 2017 | The effect on respiratory capacity using different respiration buffers. |
Soendergaard 2016 Abstract IOC109 | 2016 | Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01. |
Dohlmann 2014 Abstract MiP2014 | 2014 | Mitochondrial adaptations to high-intensity training in young and elderly men and women. |
Larsen 2014 Abstract MiP2014 | 2014 | The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. |
Dohlmann 2013 Abstract IOC75 | 2013 | Dohlmann T (2013) Effects of high-intense interval training on mitochondrial respiratory capacity. Mitochondr Physiol Network 18.03. |
Larsen S 2013 Abstract MiP2013 | 2013 | Larsen S, Dohlmann TL, Hindsø M, Dela F, Helge JW (2013) High intensity training decreases mitochondrial ADP sensitivity in human adipose and skeletal muscle tissue. Mitochondr Physiol Network 18.08. |