Genova Maria Luisa

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Management Committee

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Genova Maria Luisa

MitoPedia topics: EAGLE

COST: Member COST WG1: WG1 COST WG2: WG2 COST WG3: WG3 COST WG4: WG4 COST Mentor: Mentor

MC Substitute - Management Committee MitoEAGLE

Name	Genova Maria Luisa, Prof.Dr. Assistant Professor of Biochemistry
Institution	Department of Biomedical and Neuromotor Sciences, University of Bologna, IT
Address	Via Irnerio 48, 40126
City	Bologna
State/Province
Country	Italy
Email	[email protected]
Weblink
O2k-Network Lab	IT Bologna Genova ML

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Publications

	Published	Reference
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1
Lenaz 2017 Royal Society of Chemistry Publishing, London, UK	2017	Lenaz G, Tioli G, Falasca AI, Genova ML (2017) Respiratory supercomplexes in mitochondria. In: Mechanisms of primary energy trasduction in biology. M Wikstrom (ed). Royal Society of Chemistry Publishing, London, UK 296-337.
Lenaz 2010 Biochim Biophys Acta	2010	Lenaz G, Baracca A, Barbero G, Bergamini C, Dalmonte ME, Del Sole M, Faccioli M, Falasca A, Fato R, Genova ML, Sgarbi G, Solaini G (2010) Mitochondrial respiratory chain super-complex I-III in physiology and pathology. Biochim Biophys Acta 797(6-7):633-40.
Lenaz 2009 Int J Biochem Cell Biol	2009	Lenaz G, Genova ML (2009) Structural and functional organization of the mitochondrial respiratory chain: A dynamic super-assembly. Int J Biochem Cell Biol 41:1750-72.
Dalmonte 2009 J Biol Chem	2009	Dalmonte ME, Forte E, Genova ML, Giuffrè A, Sarti P, Lenaz G (2009) Control of respiration by cytochrome c oxidase in intact cells: role of the membrane potential. J Biol Chem 284:32331-5.
Lenaz 2007 Am J Physiol Cell Physiol	2007	Lenaz G, Genova ML (2007) Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling. Am J Physiol Cell Physiol 292:C1221-39. doi: 10.1152/ajpcell.00263.2006.
Bianchi 2004 J Biol Chem	2004	Bianchi C, Genova ML, Parenti Castelli G, Lenaz G (2004) The mitochondrial respiratory chain is partially organized in a supercomplex assembly: kinetic evidence using flux control analysis. J Biol Chem 279:36562-9.
Bianchi 2003 Biofactors	2003	Bianchi C, Fato R, Genova ML, Parenti Castelli F, Lenaz G (2003) Structural and functional organization of Complex I in the mitochondrial respiratory chain. Biofactors 18:3-9.

Abstracts

	Published	Reference
Genova 2019 MiP2019	2019	No abstract, Co-autor of Tioli 2019 MiP2019.
Tioli 2019 MiP2019	2019	Involvement of mitochondrial respiratory supercomplexes in anti-bacterial innate immunity.
Genova 2018 MiP2018	2018	Respiratory supercomplexes: evidence for separate though interconnected compartments of Coenzyme Q₁₀ in mammalian mitochondria.

MitoEAGLE Feedback

I would like to congratulate with you for the success of the COST action CA15203 on "Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment". I read the abstract published by e-cost and I was favorably impressed by the description of the objectives of the MitoEAGLE network aimed to improve our knowledge on mitochondrial function. I wish I could be a partner of the network! - Maria Luisa Genova (2016).

Given my professional experience in the field of bioenergetics, with specific expertise on mitochondria isolated from animal tissues, I will be mainly interested in the objectives of the WG2. In particular, my team can participate with studies about the mitochondrial function in relation to the supramolecular organization of the respiratory chain where the dynamic presence of the respiratory supercomplexes is a way to shift between the main metabolic fluxes of NAD- and FAD-dependent substrates in different metabolic conditions of the cell. Besides my basic studies on the enzyme interactions with the Coenzyme Q pool, I recently joined an Italian consortium of University laboratories whose target is to shed light on the molecular mechanisms underpinning muscle weakness and reduced muscle mass (sarcopenia) in ageing and attenuated response to exercise training stimuli in the elderly; both animal models and human subjects will be analyzed.

In addition, I will be pleased to contribute to the tasks of WG1 by developing interlaboratory proficiency tests and instrumental platform comparison.

Moreover, as a (potential) MC member of MitoEAGLE I can also offer visibility to the Action itself (i.e. WG5: MitoEAGLE dissemination and training, according to mitoglobal.org webpages) by establishing new interactions with the International Coenzyme Q10 Association (ICQA) where I act as a member of the Executive Committee. ICQA organizes biennal conferences on new highlights of Coenzyme Q research. In 2015, we held the conference in Bologna (http://conference2015.wix.com/icqaconference) and we included in the program also some scientific sessions dedicated to mitochondrial bioenergetics and diseases. I will be pleased to enforce cooperation between ICQA and MitoEAGLE. - Maria Luisa Genova (2016).

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