Carnitine palmitoyltransferase I

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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Carnitine palmitoyltransferase I


Carnitine palmitoyltransferase I (CPT 1) is a regulatory enzyme in mitochondrial long-chain acyl-CoA uptake and further oxidation. CPT 1 is associated with the outer mt-membrane and catalyses the formation of acylcarnitines from acyl-CoA and L-carnitine. There are three enzyme isoforms: CPT 1A (liver type), CPT 1B (muscle type), CPT 1C (brain type). Isoforms have significantly different kinetic and regulatory properties. Malonyl-CoA is an endogenous inhibitor of CPT 1.

Abbreviation: CPT 1

MitoPedia topics: Enzyme