Difference between revisions of "Labajova 2006 Gen Physiol Biophys"
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{{Publication | {{Publication | ||
|title=Lábajová A, Kofránek J, Kriváková P, Cervinková Z, Drahota Z (2006) Tetraphenylphosphonium-Selective Electrode as a Tool for Evaluating Mitochondrial Permeability Transition Pore Function in Isolated Rat Hepatocytes. Gen. Physiol. Biophys. 25: 325—331. | |title=Lábajová A, Kofránek J, Kriváková P, Cervinková Z, Drahota Z (2006) Tetraphenylphosphonium-Selective Electrode as a Tool for Evaluating Mitochondrial Permeability Transition Pore Function in Isolated Rat Hepatocytes. Gen. Physiol. Biophys. 25: 325—331. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/17197730 PMID: 17197730] | |||
|authors=Labajova A, Kofranek J, Krivakova P, Cervinkova Z, Drahota Z | |authors=Labajova A, Kofranek J, Krivakova P, Cervinkova Z, Drahota Z | ||
|year=2006 | |year=2006 | ||
|journal=Gen. Physiol. Biophys. | |journal=Gen. Physiol. Biophys. | ||
|mipnetlab=CZ HradecKralove CervinkovaZ | |||
|abstract=The changes in mitochondrial membrane potential (Δψm) were used as | |abstract=The changes in mitochondrial membrane potential (Δψm) were used as | ||
an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that ''in sit''u mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca<sup>2+</sup>-induced Δψm dissipation was caused by MPTP opening because this process was inhibited by cyclosporin A. MPTP opening was enhanced by the pro-oxidant tert-butyl hydroperoxide. | an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that ''in sit''u mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca<sup>2+</sup>-induced Δψm dissipation was caused by MPTP opening because this process was inhibited by cyclosporin A. MPTP opening was enhanced by the pro-oxidant tert-butyl hydroperoxide. | ||
|keywords=Tetraphenylphosphonium-selective electrode, Mitochondrial permeability transition pore, Hepatocytes | |keywords=Tetraphenylphosphonium-selective electrode, Mitochondrial permeability transition pore, Hepatocytes | ||
}} | }} | ||
{{Labeling | {{Labeling |
Revision as of 13:21, 11 November 2010
Lábajová A, Kofránek J, Kriváková P, Cervinková Z, Drahota Z (2006) Tetraphenylphosphonium-Selective Electrode as a Tool for Evaluating Mitochondrial Permeability Transition Pore Function in Isolated Rat Hepatocytes. Gen. Physiol. Biophys. 25: 325—331. |
Labajova A, Kofranek J, Krivakova P, Cervinkova Z, Drahota Z (2006) Gen. Physiol. Biophys.
Abstract: The changes in mitochondrial membrane potential (Δψm) were used as an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that in situ mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca2+-induced Δψm dissipation was caused by MPTP opening because this process was inhibited by cyclosporin A. MPTP opening was enhanced by the pro-oxidant tert-butyl hydroperoxide. • Keywords: Tetraphenylphosphonium-selective electrode, Mitochondrial permeability transition pore, Hepatocytes
• O2k-Network Lab: CZ HradecKralove CervinkovaZ
Labels:
Organism: Rat
Tissue;cell: Hepatocyte; Liver"Hepatocyte; Liver" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Oxygraph-2k