Kosenko 2010 Biology Bull: Difference between revisions
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|authors=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG | |authors=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG | ||
|year=2010 | |year=2010 | ||
|journal=Biology Bull | |journal=Biology Bull | ||
|abstract=The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 ฮผg/ml with | |abstract=The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 ฮผg/ml with | ||
succinate, 60 ฮผg/ml with pyruvate or palmitoylcarnitine, and 120 ฮผg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. | succinate, 60 ฮผg/ml with pyruvate or palmitoylcarnitine, and 120 ฮผg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. | ||
Revision as of 16:49, 1 March 2012
| Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37: 346-350. |
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Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) Biology Bull
Abstract: The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 ฮผg/ml with succinate, 60 ฮผg/ml with pyruvate or palmitoylcarnitine, and 120 ฮผg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. โข Keywords: hypoxen (Oliphen, Moscow)
Labels:
Organism: Rat
Tissue;cell: Hepatocyte; Liver"Hepatocyte; Liver" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
HRR: Oxygraph-2k
Pharmacology; Biotechnology
