Cardoso 2024 MitoFit
| Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. MitoFit Preprints 2024.2. https://doi.org/10.26124/mitofit:2024-0002. |
» MitoFit Preprints 2024.2.
OXPHOS coupling and uncoupling.
Cardoso Luiza HD, Gnaiger Erich (2024) MitoFit Prep
Abstract: Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.
• Keywords: electron transfer capacity, LEAK respiration, mitochondria, oxidative phosphorylation
• Bioblast editor: Tindle-Solomon L
• O2k-Network Lab: AT Innsbruck Oroboros
ORCID: 
Cardoso Luiza HD Gnaiger Erich
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