Cardoso 2024 MitoFit: Difference between revisions
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|topics=Coupling efficiency;uncoupling | |topics=Coupling efficiency;uncoupling | ||
|couplingstates=LEAK, OXPHOS, ET | |couplingstates=LEAK, OXPHOS, ET | ||
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Latest revision as of 13:30, 1 May 2024
Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. MitoFit Preprints 2024.2. https://doi.org/10.26124/mitofit:2024-0002 |
ยป MitoFit Preprints 2024.2.
OXPHOS coupling and uncoupling.
Cardoso Luiza HD, Gnaiger Erich (2024) MitoFit Prep
Abstract: Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.
โข Keywords: electron transfer capacity, LEAK respiration, mitochondria, oxidative phosphorylation
โข Bioblast editor: Tindle-Solomon L
โข O2k-Network Lab: AT Innsbruck Oroboros
ORCID: Cardoso Luiza HD, Gnaiger Erich
Spotlight
- Davis MS, Barrett MR, Bayly WM, Bolinger A (2023) Effect of selected fluorophores on equine skeletal muscle mitochondrial respiration. MitoFit Preprints 2023.5. https://doi.org/10.26124/mitofit:2023-0005
Cited by
- Gnaiger E (2024) Addressing the ambiguity crisis in bioenergetics and thermodynamics. MitoFit Preprints 2024.3. https://doi.org/10.26124/mitofit:2024-0003
Labels: MiParea: Respiration
Regulation: Coupling efficiency;uncoupling
Coupling state: LEAK, OXPHOS, ET
Gnaiger 2024 MitoFit