Apostolopoulou 2021 Sci Adv: Difference between revisions
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|title=Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straรburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Mรผssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. Sci Adv 7:eabi9551. | |title=Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straรburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Mรผssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551 | ||
|info=Sci Adv 7:eabi9551. [https://pubmed.ncbi.nlm.nih.gov/34623918 PMID: 34623918 Open Access] | |||
|authors=Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straรburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert Andreas S, Lehr Stefan, Muessig Karsten, Al-Hasani Hadi, Szendroedi Julia, Roden Michael | |authors=Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straรburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert Andreas S, Lehr Stefan, Muessig Karsten, Al-Hasani Hadi, Szendroedi Julia, Roden Michael | ||
|year=2021 | |year=2021 | ||
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|abstract=High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO<sub>2</sub>max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO<sub>2</sub>max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase Ce activity) or inflammatory (nuclear factor kB) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans. | |abstract=High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO<sub>2</sub>max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO<sub>2</sub>max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase Ce activity) or inflammatory (nuclear factor kB) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans. | ||
|editor=[[Plangger M]] | |editor=[[Plangger M]] | ||
|mipnetlab=DE Duesseldorf Roden M,ย US MN Rochester Nair KS | |mipnetlab=DE Duesseldorf Roden M,ย US MN Rochester Nair KS, DE Cologne Pesta D | ||
}} | }} | ||
{{Labeling | {{Labeling |
Latest revision as of 13:41, 22 June 2022
Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straรburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Mรผssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551 |
ยป Sci Adv 7:eabi9551. PMID: 34623918 Open Access
Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straรburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert Andreas S, Lehr Stefan, Muessig Karsten, Al-Hasani Hadi, Szendroedi Julia, Roden Michael (2021) Sci Adv
Abstract: High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO2max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO2max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase Ce activity) or inflammatory (nuclear factor kB) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans.
โข Bioblast editor: Plangger M โข O2k-Network Lab: DE Duesseldorf Roden M, US MN Rochester Nair KS, DE Cologne Pesta D
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Pathology: Diabetes
Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Coupling state: LEAK, OXPHOS, ET
Pathway: N, NS, ROX
HRR: Oxygraph-2k, O2k-Fluorometer
2021-10, AmR