Chakrabarti 2019 MiP2019: Difference between revisions
No edit summary |
No edit summary |
||
Line 9: | Line 9: | ||
|editor=[[Plangger M]], [[Tindle-Solomon L]] | |editor=[[Plangger M]], [[Tindle-Solomon L]] | ||
}} | }} | ||
{{Labeling}} | {{Labeling | ||
|area=Comparative MiP;environmental MiP, Gender | |||
|diseases=Parkinson's | |||
|organism=Human | |||
|tissues=Nervous system | |||
}} | |||
== Affiliations == | == Affiliations == | ||
::::Ingram TL(1), Ortori C(2), Shephard F(1), Barrett D(2), Chakrabarti L(1) | ::::Ingram TL(1), Ortori C(2), Shephard F(1), Barrett D(2), Chakrabarti L(1) |
Revision as of 14:38, 25 September 2019
Levels of eicosanoids and cytokines reveal sex differences in cerebellar mitochondria in Parkinsonβs disease and controls. |
Link: MiP2019
Ingram TL, Ortori C, Shephard F, Barrett D, Chakrabarti L (2019)
Event: MiP2019
Ageing is associated with an increase in inflammatory processes[1]. However, it is not clear whether inflammation is a driver, or a consequence of mechanisms of ageing. Parkinsonβs disease (PD) occurs more frequently with increased age and is associated with mitochondrial dysfunction and also neuro-inflammation[2]. An under-investigated feature of PD is the sex disparity in disease risk, symptomology, time of onset, and progression[3]. We have obtained absolute quantitation of oxylipins and endocannabinoids, and measured cytokine levels from cerebellar enriched mitochondrial fractions. Mitochondrial fractions from post mortem cerebellar tissue of age-matched male and female patients and controls were surveyed in order to pinpoint pathways that could be targeted to modify disease. Many of the inflammatory species we interrogated were present in significantly different quantities when the sexes were compared. Sex specific disease profiling can lead to the identification of protective factors and also lead to a personalised medicine approach.
β’ Bioblast editor: Plangger M, Tindle-Solomon L
Labels: MiParea: Comparative MiP;environmental MiP, Gender Pathology: Parkinson's
Organism: Human Tissue;cell: Nervous system
Affiliations
- Ingram TL(1), Ortori C(2), Shephard F(1), Barrett D(2), Chakrabarti L(1)
- SVMS
- School Pharmacy; Univ Nottingham, UK. - [email protected]
- Ingram TL(1), Ortori C(2), Shephard F(1), Barrett D(2), Chakrabarti L(1)
References
- Currais A (2015) Ageing and inflammation - A central role for mitochondria in brain health and disease. Ageing Res Rev 21:30β42.
- Bose A, Beal MF (2016) Mitochondrial dysfunction in Parkinsonβs disease. J Neurochem 139:216-31.
- Savica R, Grossardt BR, Bower JH, Ahlskog JE, Rocca WA (2013) Risk factors for Parkinsonβs disease may differ in men and women: an exploratory study. Horm Behav 63:308β14.