US CO Colorado Springs Jacobs RA

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US CO Colorado Springs Jacobs RA

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Human Bioenergetics

University of Colorado Colorado Springs

Department of Biology

Address 1420 Austin Bluffs Pkwy

Osborne Center for Science & Engineering

Room A202, 81918

City Colorado Springs
State/Prov Colorado (CO)
Country USA
Weblink
Contact Jacobs Robert A
Team Batterson Philip
Team previous
Status 2 Power-O2k 2017-
Oroboros Events IOC136, MiP2013, Bioblast 2012, IOC60, IOC55
Topics Human bioenergetics in health and disease; Human Performance; Environmental effects on biological thermodynamics (emphasis on hypoxia/high altitude); and Aging


O2k-Publications

 PublishedReference
Batterson 2023 Physiol Rep2023Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840
Walsh 2023 FASEB J2023Walsh MA, Musci RV, Jacobs RA, Hamilton KL (2023) A practical perspective on how to develop, implement, execute, and reproduce high-resolution respirometry experiments: The physiologist's guide to an Oroboros O2k. https://doi.org/10.1096/fj.202301644rr
Batterson 2020 Physiol Rep2020Batterson PM, Norton MR, Hetz SE, Rohilla S, Lindsay KG, Subudhi AW, Jacobs RA (2020) Improving biologic predictors of cycling endurance performance with near-infrared spectroscopy derived measures of skeletal muscle respiration: E Pluribus Unum. Physiol Rep 8:e14342.
Meinild Lundby 2018 Acta Physiol (Oxf)2018Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C (2018) Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta Physiol (Oxf) 222, e12905.
Schoenenberger 2016 Cancer Res2016Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36.
Christensen 2016 J Appl Physiol (1985)2016Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27.
Jacobs 2016 J Physiol2016Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66.
Montero 2015 J Physiol2015Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol 593:4677-88.
Robach 2014 Med Sci Sports Exerc2014Robach P, Bonne T, Flück D, Bürgi S, Toigo M, Jacobs R, Lundby C (2014) Hypoxic training: effect on mitochondrial function and aerobic performance in hypoxia. Med Sci Sports Exerc 46:1936-45.
Jacobs 2013 J Appl Physiol2013Jacobs R, Flück D, Bonne TC, Bürgi S, Christensen PM, Toigo M, Lundby C (2013) Improvements in exercise performance 1 with high-intensity interval training 2 coincide with an increase in skeletal muscle mitochondrial content and function. J Appl Physiol 115:785-93.
Jacobs 2013 J Gerontol A Biol Sci Med Sci2013Jacobs R, Diaz V, Soldini L, Haider T, Thomassen M, Nordsborg NB, Gassmann M, Lundby C (2013) Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function. J Gerontol A Biol Sci Med Sci 68:1010-22.
Jacobs 2013 Exp Physiol2013Jacobs R, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2013) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 98:245-55.
Jacobs 2013 Am J Physiol Endocrinol Metab2013Jacobs R, Meinild AK, Nordsborg NB, Lundby C (2013) Lactate oxidation in human skeletal muscle mitochondria. Am J Physiol Endocrinol Metab 304:686-94.
Robach 2012 Br J Sports Med2012Robach P, Siebenmann C, Jacobs R, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Diaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO2max following normobaric live high-train low in endurance-trained athletes. Br J Sports Med Jul 12. 46:822-7.
Jacobs 2012 FASEB J2012Jacobs R, Siebenmann C, Hug M, Toigo M, Meinild AK, Lundby C (2012) Twenty-eight days at 3454-m altitude diminishes respiratory capacity but enhances efficiency in human skeletal muscle mitochondria. FASEB J 90:5192-200.
Zobi 2012 Dalton Trans2012Zobi F, Blacque O, Jacobs RA, Schaub MC, Bogdanova AY (2012) 17 e- rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application. Dalton Trans 41:370-8.
Jacobs 2012 J Appl Physiol2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes. J Appl Physiol 114:344-50.
Jacobs 2013b Exp Physiol2012Jacobs R, Díaz V, Meinild AK, Gassmann M, Lundby C (2012) The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function. Exp Physiol 98:908-21.
Jacobs 2011 J Appl Physiol2011Jacobs R, Rasmussen P, Siebenmann C, Díaz V, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C (2011) Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 111:1422–30.

O2k-Abstracts

 PublishedReference
Lundby 2013 Abstract MiP20132013Lundby C, Bonne T, Flück D, Jacobs R, Meinild AK, Lundby S, Robach P (2013) The effects of hypoxic training on aerobic performance in normoxia and moderate hypoxia: a randomized, double blind, placebo controlled study. Mitochondr Physiol Network 18.08.
Jacobs 2013 Abstract MiP20132013Jacobs R, Flück D, Bonne TC, Bürgi S, Christensen PM, Toigo M, Lundby C (2013) Improvements in exercise performance with high-intensity interval training are facilitated by an increase in skeletal muscle mitochondria content. Mitochondr Physiol Network 18.08.
Jacobs 2012 Abstract Bioblast2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.
Pesta 2011Abstract ACSM2011Pesta D, Jacobs R, Macek C, Hoppel F, Faulhaber M, Lundby C, Burtscher M, Gnaiger E, Schocke M (2011) Investigation of muscle metabolism of the quadriceps via high-resolution respirometry and 31P MRS in connection with a 10 week endurance training. Medicine & Science in Sports & Exercise 43: 71
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